SIRP beta 1 Protein, Human (HEK293, His-Avi)
SIRP beta 1 protein negatively regulates receptor tyrosine kinase signaling and recruits SYK for myeloid cell activation. It interacts with TYROBP as a homodimer, facilitating SYK recruitment. This intricate molecular interplay is crucial for modulating myeloid cell activation and regulating cellular signaling. SIRP beta 1 occupies a central position in protein interactions that contribute to its functional role. SIRP beta 1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP Beta 1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
SIRP beta 1 protein negatively regulates receptor tyrosine kinase signaling and recruits SYK for myeloid cell activation. It interacts with TYROBP as a homodimer, facilitating SYK recruitment. This intricate molecular interplay is crucial for modulating myeloid cell activation and regulating cellular signaling. SIRP beta 1 occupies a central position in protein interactions that contribute to its functional role. SIRP beta 1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP Beta 1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background
SIRP beta 1 protein, an immunoglobulin-like cell surface receptor, plays a vital role in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Additionally, it participates in the recruitment of the tyrosine kinase SYK, triggering the activation of myeloid cells when associated with TYROBP. Existing as a homodimer with disulfide linkages, SIRP beta 1 interacts specifically with TYROBP, leading to the recruitment of SYK. This intricate molecular interplay positions SIRP beta 1 at the nexus of cellular signaling regulation, highlighting its significance in modulating myeloid cell activation and the intricate network of protein interactions that contribute to its functional role.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-8*His
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Accession
O00241-1 (E30-A369)
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Molecular Construction
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N-term
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SIRP Beta 1 (E30-A369)
Accession # O00241-1 -
8*His-Avi
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C-term
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Protein Length
Extracellular Domain
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Synonyms
SIRPB1; Signal-Regulatory Protein Beta-1 Isoform 3; Signal Regulatory Protein Beta 1; Signal-Regulatory Protein Beta 1; SIRP-BETA-1; Alternative Protein SIRPB1; CD172b; SIRP-Beta-1 Isoform 3; CD172 Antigen-Like Family Member B; CD172b Antigen; Signal-Regu
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AA Sequence
EDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTA
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Predicted Molecular Mass
40 kDa
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Molecular Weight
Approximately 52-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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