1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. NS383

NS383 

Cat. No.: HY-131879
Handling Instructions

NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits.

For research use only. We do not sell to patients.

NS383 Chemical Structure

NS383 Chemical Structure

CAS No. : 309711-59-9

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Description

NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits[1].

Molecular Weight

321.37

Formula

C19H19N3O2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NS383
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