2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT1A modulator 2 hydrochloride

5-HT1A modulator 2 hydrochloride 

Cat. No.: HY-136621 Purity: 99.72%
COA Handling Instructions

5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT (HY-112061), is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding.

For research use only. We do not sell to patients.

5-HT1A modulator 2 hydrochloride Chemical Structure

5-HT1A modulator 2 hydrochloride Chemical Structure

CAS No. : 3880-76-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT (HY-112061), is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding[1].

IC50 & Target

Ki: 53 nM (5-HT1A)[1]
In Vitro

5-HT1A modulator 2 hydrochloride (compound 3) binds to 5-HT1A with a Ki of 53 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

213.70

Appearance

Solid

Formula

C11H16ClNO
CAS No.
SMILES

NC1CC2=C(C=CC=C2OC)CC1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (467.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6795 mL 23.3973 mL 46.7946 mL
5 mM 0.9359 mL 4.6795 mL 9.3589 mL
10 mM 0.4679 mL 2.3397 mL 4.6795 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.70 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.70 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.72%

COA (250 KB) HNMR (213 KB) LCMS (227 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

5-HT1A modulator 23880-76-05-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HTIAserotoninderivative8-OH-DPAT2-(Alky1amino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralinInhibitorinhibitorinhibit

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5-HT1A modulator 2 hydrochloride
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