1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. 8-OH-DPAT

8-OH-DPAT (Synonyms: 8-Hydroxy-DPAT)

Cat. No.: HY-112061 Purity: >98.0%
Handling Instructions

8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).

For research use only. We do not sell to patients.

8-OH-DPAT Chemical Structure

8-OH-DPAT Chemical Structure

CAS No. : 78950-78-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
25 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 220 In-stock
Estimated Time of Arrival: December 31
100 mg USD 390 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).

IC50 & Target

5-HT1A Receptor

8.19 (pIC50)

5-HT7 Receptor

466 nM (Ki)

In Vitro

8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5)[1]. 8-OH-DPAT has high affinity at 5-HT7 with a Ki of 466 nM, and does not bind to 5-HT6 or 5-HT4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

247.38

Formula

C₁₆H₂₅NO

CAS No.

78950-78-4

SMILES

OC1=C2CC(N(CCC)CCC)CCC2=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 155 mg/mL (626.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0424 mL 20.2118 mL 40.4236 mL
5 mM 0.8085 mL 4.0424 mL 8.0847 mL
10 mM 0.4042 mL 2.0212 mL 4.0424 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[3]

Mice[3]
The locomotor activity of mice is measured by an infrared sensor placed in individual home cages. To compare the locomotor activity in the light and dark periods, locomotor activity is monitored at 30-min intervals starting at 8:00 a.m. and 8:00 p.m., respectively. To measure the effects of psychostimulants (8-OH-DPAT, 1, 3 mg/kg, s.c; etc.) on locomotor activity in the dark period, all drugs are administered at 8:00 p.m., and locomotor activity is then measured through 3 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

8-OH-DPAT8-Hydroxy-DPAT5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product Name:
8-OH-DPAT
Cat. No.:
HY-112061
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