2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 8-OH-DPAT hydrobromide

8-OH-DPAT hydrobromide  (Synonyms: 8-Hydroxy-DPAT hydrobromide)

Cat. No.: HY-15688 Purity: 99.88%
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8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent, brain-penetrant and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.

For research use only. We do not sell to patients.

CAS No. : 76135-31-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of 8-OH-DPAT hydrobromide:

8-OH-DPAT hydrobromide Related Antibodies

Top Publications Citing Use of Products

    8-OH-DPAT hydrobromide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Oct 9.  [Abstract]

    Microinjecting 8-OH-DPAT (4  mM) into the dorsal raphe nucleus (DRN), followed by esflurbiprofen treatment (20 mg/kg, intraperitoneally) at 5 min. TST (F (3, 28) = 6.237, P = 0.0022), FST (F (3, 28) = 4.385, P = 0.0119) were performed 2 h post treatment (n = 8). The results showed that 8-OH-DPAT, a selective 5-HT₁A receptor agonist, abolished the rapid antidepressant activity of esflurbiprofen, confirming that esflurbiprofen exerted antidepressant effects by inhibiting the negative feedback mediated by 5-HT₁A autoreceptors.

    8-OH-DPAT hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2026 Feb 28:357:120876.  [Abstract]

    Microinjecting 8-OH-DPAT (4 mM) into the dorsal raphe nucleus (DRN) followed by AITC ME treatment. TST (F (3,28) = 3.435, P = 0.0303, n = 8) and FST (F (3,28) = 14.79, P < 0.0001, n = 8) were performed 2 h later. The results showed that 8-OH-DPAT, a 5-HT₁AR agonist, abolished the antidepressant activity of AITC ME, indicating that the antidepressant effect of AITC ME was associated with the autoreceptor-mediated negative feedback mechanism of 5-HT₁AR in the DRN.

    8-OH-DPAT hydrobromide purchased from MedChemExpress. Usage Cited in: Mol Neurobiol. 2025 Nov 24;63(1):163.  [Abstract]

    Co-administration of the sigma-1 receptor (S1R) agonist SA-4503 (1 mg/kg, i.p.) and the 5-HT₁A receptor agonist 8-OH-DPAT (0.3 mg/kg, i.p.) produced synergistic anxiolytic- and antidepressant-like effects.

    8-OH-DPAT hydrobromide purchased from MedChemExpress. Usage Cited in: Neurochem Int. 2025 Jan 28:105937.  [Abstract]

    Statistical analysis of the percentage of c-Fos+ TPH2+ cells in the experimental groups of mice (n = 6, with samples from at least three mice per group). The results showed that treatment with SA-4503 (1.0 mg/kg; p.o. ; once daily for 3 days), alone or in combination with 8-OH-DPAT (0.3 mg/kg ; i.g.; once daily for 3 days), activated a greater number of serotonergic neurons in the DRN of mice subjected to CRS. Similarly, the combined treatment significantly enhanced the effect of 8-OH-DPAT alone (P = 0.0022).

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    Description

    8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent, brain-penetrant and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].

    IC50 & Target[1]

    5-HT1A Receptor

     

    5-HT1A Receptor

    8.19 (pIC50)

    In Vitro

    8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide has no effect on 5-HT1B binding at concentrations lower than 100 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    8-OH-DPAT hydrobromide Related Antibodies
    In Vivo

    8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide (32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    328.29

    Formula

    C16H26BrNO
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1=C2CC(N(CCC)CCC)CCC2=CC=C1.[H]Br
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (76.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0461 mL 15.2304 mL 30.4609 mL
    5 mM 0.6092 mL 3.0461 mL 6.0922 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.88%

    SDS (393 KB)

    COA (250 KB) HNMR (267 KB) LCMS (97 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0461 mL 15.2304 mL 30.4609 mL 76.1522 mL
    5 mM 0.6092 mL 3.0461 mL 6.0922 mL 15.2304 mL
    10 mM 0.3046 mL 1.5230 mL 3.0461 mL 7.6152 mL
    15 mM 0.2031 mL 1.0154 mL 2.0307 mL 5.0768 mL
    20 mM 0.1523 mL 0.7615 mL 1.5230 mL 3.8076 mL
    25 mM 0.1218 mL 0.6092 mL 1.2184 mL 3.0461 mL
    30 mM 0.1015 mL 0.5077 mL 1.0154 mL 2.5384 mL
    40 mM 0.0762 mL 0.3808 mL 0.7615 mL 1.9038 mL
    50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5230 mL
    60 mM 0.0508 mL 0.2538 mL 0.5077 mL 1.2692 mL
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    8-OH-DPAT hydrobromide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    8-OH-DPAT76135-31-48-Hydroxy-DPAT5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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