1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Pergolide mesylate

Pergolide mesylate  (Synonyms: Pergolide methanesulfonate; LY127809)

Cat. No.: HY-13720A Purity: 99.92%
COA Handling Instructions

Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.

For research use only. We do not sell to patients.

Pergolide mesylate Chemical Structure

Pergolide mesylate Chemical Structure

CAS No. : 66104-23-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 84 In-stock
25 mg USD 144 In-stock
50 mg USD 228 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pergolide mesylate:

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1 Publications Citing Use of MCE Pergolide mesylate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

IC50 & Target[2]

D2 Receptor

 

D1 Receptor

 

In Vitro

Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: SH-SY5Y cells
Concentration: 0.01 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 50 μM
Incubation Time: Pretreated for 2 hours
Result: Dose-dependently inhibited H2O2-induced cell death in SH-SY5Y neuroblastoma cells.
In Vivo

Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance[3] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (200-250 g) induced with 6-hydroxydopamine (6-OHDA)[3]
Dosage: 0.3 mg/kg
Administration: Intraperitoneal injection; daily; 11 days
Result: A reduced number of working/reference memory errors was observed. And significant decreased of MDA level.
Clinical Trial
Molecular Weight

410.59

Formula

C20H30N2O3S2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=CC=CC2=C43.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (60.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4355 mL 12.1776 mL 24.3552 mL
5 mM 0.4871 mL 2.4355 mL 4.8710 mL
10 mM 0.2436 mL 1.2178 mL 2.4355 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

References
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Pergolide mesylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pergolide mesylate
Cat. No.:
HY-13720A
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