1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pergolide mesylate

Pergolide mesylate (Synonyms: Pergolide methanesulfonate; LY127809)

Cat. No.: HY-13720A Purity: 99.93%
Handling Instructions

Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

For research use only. We do not sell to patients.

Pergolide mesylate Chemical Structure

Pergolide mesylate Chemical Structure

CAS No. : 66104-23-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
25 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 228 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist. Target: Dopamine Receptor Pergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline [1, 2]. Pergolide mesylate decreases plasma prolactin concentrations [3]. The weak agonist activity of pergolide at D1 receptors somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. The drug is in decreasing use, as it is reported to be associated with a form of heart disease called cardiac fibrosis. The use of pergolide or cabergoline is associated with a significantly increased risk of newly diagnosed cardiac-valve regurgitation [4].

Clinical Trial
Molecular Weight

410.59

Formula

C₂₀H₃₀N₂O₃S₂

CAS No.

66104-23-2

SMILES

[H][[email protected]@]1(N(CCC)C[[email protected]](CSC)C[[email protected]@]12[H])CC3=CNC4=CC=CC2=C43.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (60.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4355 mL 12.1776 mL 24.3552 mL
5 mM 0.4871 mL 2.4355 mL 4.8710 mL
10 mM 0.2436 mL 1.2178 mL 2.4355 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.93%

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Product Name:
Pergolide mesylate
Cat. No.:
HY-13720A
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