1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pergolide mesylate

Pergolide mesylate (Synonyms: Pergolide methanesulfonate; LY127809)

Cat. No.: HY-13720A Purity: 99.93%
Handling Instructions

Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.

For research use only. We do not sell to patients.

Pergolide mesylate Chemical Structure

Pergolide mesylate Chemical Structure

CAS No. : 66104-23-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
25 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 228 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

IC50 & Target[2]

D2 Receptor

 

D1 Receptor

 

In Vitro

Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: SH-SY5Y cells
Concentration: 0.01 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 50 μM
Incubation Time: Pretreated for 2 hours
Result: Dose-dependently inhibited H2O2-induced cell death in SH-SY5Y neuroblastoma cells.
In Vivo

Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (200-250 g) induced with 6-hydroxydopamine (6-OHDA)[3]
Dosage: 0.3 mg/kg
Administration: Intraperitoneal injection; daily; 11 days
Result: A reduced number of working/reference memory errors was observed. And significant decreased of MDA level.
Clinical Trial
Molecular Weight

410.59

Formula

C₂₀H₃₀N₂O₃S₂

CAS No.
SMILES

[H][[email protected]@]1(N(CCC)C[[email protected]](CSC)C[[email protected]@]12[H])CC3=CNC4=CC=CC2=C43.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (60.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4355 mL 12.1776 mL 24.3552 mL
5 mM 0.4871 mL 2.4355 mL 4.8710 mL
10 mM 0.2436 mL 1.2178 mL 2.4355 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.93%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pergolide LY127809LY127809LY 127809LY-127809Dopamine ReceptorParkinson'sdiseasehyperprolactinaemiaergolineD1-receptorsD2-receptorMDAneuroprotectionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pergolide mesylate
Cat. No.:
HY-13720A
Quantity:
MCE Japan Authorized Agent: