1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. 2-Methyl-5-HT

2-Methyl-5-HT (Synonyms: 2-Methyl-5-hydroxytryptamine; 2-Methylserotonin; 2-Me-5-HT)

Cat. No.: HY-19358 Purity: 98.09%
Handling Instructions

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.

For research use only. We do not sell to patients.

2-Methyl-5-HT Chemical Structure

2-Methyl-5-HT Chemical Structure

CAS No. : 78263-90-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 810 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2-Methyl-5-HT:

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Description

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].

IC50 & Target

5-HT3 Receptor

 

In Vivo

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) significantly decreases time of immobility thus showing anti-depressive-like effects[1].

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3 mg/kg
Administration: I.p.; 45 minutes
Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
Molecular Weight

190.24

Formula

C₁₁H₁₄N₂O

CAS No.

78263-90-8

SMILES

OC1=CC2=C(NC(C)=C2CCN)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (657.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2565 mL 26.2826 mL 52.5652 mL
5 mM 1.0513 mL 5.2565 mL 10.5130 mL
10 mM 0.5257 mL 2.6283 mL 5.2565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

2-Methyl-5-HT2-Methyl-5-hydroxytryptamine 2-Methylserotonin2-Me-5-HT5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product name:
2-Methyl-5-HT
Cat. No.:
HY-19358
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