1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Almotriptan

Almotriptan 

Cat. No.: HY-B0383A
Handling Instructions

Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.

For research use only. We do not sell to patients.

Almotriptan Chemical Structure

Almotriptan Chemical Structure

CAS No. : 154323-57-6

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Description

Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine. IC50: Target: 5-hydroxytryptamine1B/1D (5-HT1B/1D) Receptor Almotriptan is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. Almotriptan showed low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors in several species, including the human, while affinity for 5-HT receptors other than 5-HT(1B/1D) was clearly less. Almotriptan did not exhibit significant affinity for several non-5-HT receptors studied up to 100 microM. Almotriptan inhibited forskolin-stimulated cyclic AMP accumulation in HeLa cells transfected with 5-HT(1B) or 5-HT(1D) human receptors [1]. Almotriptan had a mild antiemetic effect and a slight, transient diuretic effect in dogs, although the latter effect is probably of no clinical relevance. In addition, no effect on the respiratory system of conscious guinea pigs was observed following almotriptan treatment. These results indicate that almotriptan has a favourable safety profile with respect to the central nervous, renal and respiratory systems [2].

Molecular Weight

335.46

Formula

C₁₇H₂₅N₃O₂S

CAS No.

154323-57-6

SMILES

O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(N3CCCC3)=O

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Keywords:

Almotriptan5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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