1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Almotriptan malate

Almotriptan malate (Synonyms: PNU180638)

Cat. No.: HY-B0383 Purity: 99.49%
Handling Instructions

Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.

For research use only. We do not sell to patients.

Almotriptan malate Chemical Structure

Almotriptan malate Chemical Structure

CAS No. : 181183-52-8

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Based on 1 publication(s) in Google Scholar

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Description

Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine. IC50: Target: 5-hydroxytryptamine1B/1D (5-HT1B/1D) Receptor Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. Almotriptan showed low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors in several species, including the human, while affinity for 5-HT receptors other than 5-HT(1B/1D) was clearly less. Almotriptan did not exhibit significant affinity for several non-5-HT receptors studied up to 100 microM. Almotriptan inhibited forskolin-stimulated cyclic AMP accumulation in HeLa cells transfected with 5-HT(1B) or 5-HT(1D) human receptors [1]. Almotriptan had a mild antiemetic effect and a slight, transient diuretic effect in dogs, although the latter effect is probably of no clinical relevance. In addition, no effect on the respiratory system of conscious guinea pigs was observed following almotriptan treatment. These results indicate that almotriptan has a favourable safety profile with respect to the central nervous, renal and respiratory systems [2].

Molecular Weight

469.55

Formula

C₂₁H₃₁N₃O₇S

CAS No.

181183-52-8

SMILES

O=C(O)C(O)CC(O)=O.O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(N3CCCC3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

AlmotriptanPNU180638PNU 180638PNU-1806385-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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