Naratriptan hydrochloride (Standard)
Naratriptan (GR-85548A) hydrochloride (Standard) is the analytical standard of Naratriptan hydrochloride (HY-B0197A). This product is intended for research and analytical applications. Naratriptan is a selective 5-HT1B/1D receptor agonist. Naratriptan is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery). Naratriptan also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98%
- CAS 番号: 143388-64-1
- 分子式: C17H26ClN3O2S
- 分子量:371.93
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-B0197A
Naratriptan hydrochloride5-HT(1B/1D) Receptor Agonist -
HY-B0670A
Dihydroergotamine mesylate5-HT1B/1D Agonist -
HY-B1473A
Serotonin5-HT Receptor Agonist -
HY-15934
X-GALβ-Galactosidase Substrate -
HY-B0229
Zolmitriptan5-HT1B/1D Agonist -
HY-B0206
Rizatriptan benzoate5-HT1 Agonist -
HY-DY2002
X-GAL (solution)β-Galactosidase Substrate -
HY-B0383
Almotriptan malate5-HT1B/1D Receptor Agonist -
HY-B1658A
Frovatriptan succinate hydrate5-HT1B/1D Receptor Agonist -
HY-14153
TegaserodSerotonin Receptor 4 Agonist -
HY-B0020
Tropisetron Hydrochloride5-HT3 Receptor Antagonist -
HY-128731
5-Methoxy-DL-tryptophanEndogenous Metabolite
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 143388-64-1
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分子量 371.93
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分子式 C17H26ClN3O2S
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SMILES
O=S(CCC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)(NC)=O.Cl
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別名
GR-85548A hydrochloride (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Rhoden E, et al. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res. 2013 May;98(2):186-91. [Content Brief]
[2]. Hoskin KL, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res. 2004 Feb 13;998(1):91-9. [Content Brief]
[3]. Connor HE, et al. Naratriptan: biological profile in animal models relevant to migraine. Cephalalgia. 1997 May;17(3):145-52. [Content Brief]
[4]. Donaldson C, et al. The role of 5-HT1B and 5-HT1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons. Neuropharmacology. 2002 Mar;42(3):374-85. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Naratriptan hydrochloride (Standard) 関連分類
HY-B0197AR 関連分類
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