CC2D1A Antibody (YA3002)
(Synonyms: Coiled coil and C2 domain containing 1A; FREUD 1; Freud 1/Aki1; MRT3)CC2D1A Antibody (YA3002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CC2D1A.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF, FC
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 | 1:50-1:100 |
Product Details
CC2D1A Antibody (YA3002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CC2D1A.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 130 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 104 kDa
Entrez Gene: 54862 Human ; 212139 Mouse ; 288908 Rat
SwissProt: Q6P1N0 Human ; Q8K1A6 Mouse ; Q66HA5 Rat
OMIM: 608443 Human
A synthesized peptide derived from human CC2D1A aa750-951/951.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
CC2D1A transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis
-
Subcellular Localization
Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
-
Isoforms & Post-Translational Modification
Q6P1N0 has 2 isomers: Q6P1N0-1: 104062 Da (predicted); Q6P1N0-2: 103934 Da (predicted).
Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21 -
SwissProt ID
-
Synonyms
Coiled coil and C2 domain containing 1A; FREUD 1; Freud 1/Aki1; MRT3
-
Research Field
Epigenetics and Nuclear Signaling
Documentation
Powered by Bioz
