1. Neuronal Signaling
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. Notch
    Drug Metabolite
  3. IMR-1A

IMR-1A 

Cat. No.: HY-100431A Purity: 98.23%
Handling Instructions

IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitors with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A.

For research use only. We do not sell to patients.

IMR-1A Chemical Structure

IMR-1A Chemical Structure

CAS No. : 331862-41-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 301 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitors with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].

IC50 & Target

IC50: 0.5 μM (Notch)[1]

In Vivo

IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration[1].

Animal Model: Male C57 BL/6 mice[1]
Dosage: 2 mg/kg (i.v.) and 100 mg/kg (i.p)
Administration: I.v. and i.p.
Result: Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
Molecular Weight

325.36

Formula

C₁₃H₁₁NO₅S₂

CAS No.

331862-41-0

SMILES

O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (95.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL
5 mM 0.6147 mL 3.0735 mL 6.1470 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

IMR-1ANotchDrug MetaboliteInhibitorinhibitorinhibit

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