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Cat. No.: HY-100431AR

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IMR-1A (Standard)

IMR-1A (Standard) is the analytical standard of IMR-1A. This product is intended for research and analytical applications. IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].

For research use only. We do not sell to patients.

CAS No.: 331862-41-0
Formula: C₁₃H₁₁NO₅S₂
Molecular Weight:325.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IMR-1A (Standard) Chemical Structure

CAS No.: 331862-41-0

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Fluorescent Dye

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 331862-41-0
Molecular Weight 325.36
Formula C₁₃H₁₁NO₅S₂
SMILES

O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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