1. Vitamin D Related
  2. VD/VDR
  3. Lexacalcitol

Lexacalcitol (Synonyms: KH1060)

Cat. No.: HY-32340 Purity: 99.42%
Handling Instructions

Lexacalcitol (KH1060), a vitamin D analog, is potent regulators of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.

For research use only. We do not sell to patients.

Lexacalcitol Chemical Structure

Lexacalcitol Chemical Structure

CAS No. : 131875-08-6

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1 mg USD 350 In-stock
Estimated Time of Arrival: December 31
5 mg USD 800 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lexacalcitol (KH1060), a vitamin D analog, is potent regulators of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].

In Vitro

Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female spontaneously diabetic NOD mice[2]
Dosage: 0.5 mg/kg/2 days
Administration: Intraperitoneal injection
Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
Molecular Weight

460.69

Formula

C₂₉H₄₈O₄

CAS No.

131875-08-6

SMILES

C[[email protected]]1(CCC/2)[[email protected]](CC[[email protected]@H]1[[email protected]@H](C)OCCCC(CC)(CC)O)([H])C2=C\C=C(C[[email protected]@H](O)C[[email protected]@H]3O)/C3=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

References
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Keywords:

LexacalcitolKH1060KH 1060KH-1060VD/VDRVitamin DVitamin D receptorantiproliferativecelldifferentiating1a,25-(OH)2D3immunosuppressiveauto-immunediseasespsoriasispreventiongraftrejectionInhibitorinhibitorinhibit

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Lexacalcitol
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