2. Metabolic Enzyme/Protease
  3. UGT
  4. Trifluoperazine N-Glucuronide

Trifluoperazine N-Glucuronide  (Synonyms: UGT1A4)

Cat. No.: HY-137083 Purity: 95.80%
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SDS
Handling Instructions Technical Support

Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation.

For research use only. We do not sell to patients.

Trifluoperazine N-Glucuronide

Trifluoperazine N-Glucuronide Chemical Structure

CAS No. : 165602-90-4

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Other Forms of Trifluoperazine N-Glucuronide:

Trifluoperazine N-Glucuronide Related Antibodies

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Description

Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1].

In Vitro

Trifluoperazine N-Glucuronide (1~10 μg; HEK293 cells) expression levels is 0.14 unit/mg protein[1].
Trifluoperazine N-Glucuronide coexpression affects the activity of human UGT1A9. The imipramine N-glucuronide formation by the single expression system of trifluoperazine N-Glucuronide follows the Michaelis-Menten equation. Trifluoperazine N-Glucuronide interacts with the human UGT1A1 and UGT1A6, affecting the enzymatic activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trifluoperazine N-Glucuronide Related Antibodies
Molecular Weight

583.62

Formula

C27H32F3N3O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC(C(C=C1N2CCCN3CC[N+](C)([C@H]4[C@@H]([C@H]([C@@H]([C@@H](C([O-])=O)O4)O)O)O)CC3)=CC=C1SC5=C2C=CC=C5)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (42.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7134 mL 8.5672 mL 17.1344 mL
5 mM 0.3427 mL 1.7134 mL 3.4269 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.6%

SDS (252 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7134 mL 8.5672 mL 17.1344 mL 42.8361 mL
5 mM 0.3427 mL 1.7134 mL 3.4269 mL 8.5672 mL
10 mM 0.1713 mL 0.8567 mL 1.7134 mL 4.2836 mL
15 mM 0.1142 mL 0.5711 mL 1.1423 mL 2.8557 mL
20 mM 0.0857 mL 0.4284 mL 0.8567 mL 2.1418 mL
25 mM 0.0685 mL 0.3427 mL 0.6854 mL 1.7134 mL
30 mM 0.0571 mL 0.2856 mL 0.5711 mL 1.4279 mL
40 mM 0.0428 mL 0.2142 mL 0.4284 mL 1.0709 mL
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Trifluoperazine N-Glucuronide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifluoperazine N-Glucuronide165602-90-4UGT1A4UGTUDP-glucuronosyltransferaseUridine diphosphate glucuronosyltransferaseInhibitorinhibitorinhibit

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