1. GPCR/G Protein
  2. GHSR

JMV 2959 

Cat. No.: HY-U00433
Handling Instructions

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.

For research use only. We do not sell to patients.

JMV 2959 Chemical Structure

JMV 2959 Chemical Structure

CAS No. : 925238-89-7

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25 mg USD 410 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.

IC50 & Target

IC50: 32 nM (GHS-R1a)

In Vitro

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. JMV 2959 does not induce any intracellular calcium mobilization by itself[1].

In Vivo

When administered alone, it does not increase food intake and does not significantly stimulate growth hormone (GH) release[1]. JMV 2959 dose dependently decreases the startle response (F(3.42)=4.4, p<0.01) and increases %prepulse inhibition (PPI) (F(3.42)=3.9, p<0.05) in the prepulse inhibition paradigm. The alteration in the startle response is mainly due to a 27% decrease in the startle seen in the highest dose of JMV 2959 (6 mg/kg) compare to vehicle (p<0.05)[2]. 6 mg/kg JMV 2959 induces a significant suppression of locomotion on days 1 to 7 relative to baseline day 0 (F(7,49)=2.21, p<0.05). Results also reveal a significant interaction between JMV 2959 treatment and day (F(1,14)=4.397, p<0.05)[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9661 mL 9.8307 mL 19.6614 mL
5 mM 0.3932 mL 1.9661 mL 3.9323 mL
10 mM 0.1966 mL 0.9831 mL 1.9661 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Two-hundred-gram male Sprague-Dawley rats are used in the study. The animals (n=15) are randomly assigned to an initial treatment dose or vehicle and subsequently receive all the different doses tested in a counter balanced design. Each test is separated by a 3- to 4-day-long washout period. The rats are given the injection of JMV 2959 (or vehicle) 17 min prior to being placed in the startle cages (i.e., 25 min prior to the first pulse). The doses of JMV 2959 used for the dose response are 1, 3, and 6 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

508.61

Formula

C₃₀H₃₂N₆O₂

CAS No.

925238-89-7

SMILES

O=C(N[[email protected]@H](C1=NN=C(CCC2=CC=CC=C2)N1CC3=CC=C(OC)C=C3)CC4=CNC5=C4C=CC=C5)CN

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
JMV 2959
Cat. No.:
HY-U00433
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JMV 2959

Cat. No.: HY-U00433