Anamorelin
Based on 11 publication(s) in Google Scholar
Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 249921-19-5
- Formula: C31H42N6O3
- Molecular Weight:546.70
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Anamorelin
More- J Cachexia Sarcopenia Muscle. 2026 Jun;17(3):e70318. [Abstract]
- J Pharm Biomed Anal. 2016 Nov 30:131:482-496. [Abstract]
- J Sep Sci. 2016 Jan;39(2):333-41. [Abstract]
- Drug Test Anal. 2021 Feb;13(2):283-298. [Abstract]
- Discov Med. 2024 Sep 17.
- Mass Spectrom Lett. 2016, 7(3):55-63.
- Mass Spectrom Lett. 2016 Sep 30;7(3):55-63.
- Patent. US20240197718A1.
- Patent. US20240197718A1.
- Patent. US20240139176A1.
- Universität Zürich. 2023 Jun 14.
Biological Activity
Ki: 0.7 nM (Ghrelin receptor)[1]
EC50: 0.74 nM (Ghrelin receptor)[1]
Anamorelin (0.01 nM-10 μM; 15 min) stimulates growth hormone release in a dose-dependent manner in rat pituitary cells, with an EC50 of 1.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anamorelin (3.5 mg/kg; oral administration; 1-7 days) significantly elevates the levels of growth hormone and insulin-like growth factor-1 in pigs[1].
Anamorelin (3-30 mg/kg; oral administration; 28 days) does not promote tumor growth in a nude mouse model of lung cancer xenografts, but increases the body weight of nude mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice (nu/nu, Harlan) (18.4-26.6 g, 9-10 weeks old) treated A549 cells[2]
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Dosage:3, 10 and 30 mg/kg
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Administration:Oral administration (p.o.); 28 days
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Result:Did not promote tumor growth in the murine NSCLC xenograft model.
Significantly increased the percentage of mean body weight gain at the end of treatment at doses of 10 and 30 mg/kg compared with controls.
Significantly increased peak plasma levels of murine growth hormone (mGH), while peak murine insulin-like growth factor-1 (mIGF-1) levels were slightly elevated but not statistically significant.
Were well tolerated.
Chemical Information
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CAS No. 249921-19-5
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Appearance Solid
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Molecular Weight 546.70
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Formula C31H42N6O3
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Color Off-white to yellow
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SMILES
[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O
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Synonyms
RC-1291; ONO-7643
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (11)
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Journal Impact Factor
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Most Recent
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J Cachexia Sarcopenia Muscle
Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice. [Abstract]2026 Jun;17(3):e70318. PMID: 42223236 -
J Pharm Biomed Anal
Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry. [Abstract]2016 Nov 30:131:482-496. PMID: 27693991 -
J Sep Sci
Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry. [Abstract]2016 Jan;39(2):333-41. PMID: 26578461 -
Drug Test Anal
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]2021 Feb;13(2):283-298. PMID: 32852861 -
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Solvent & Solubility
DMSO : 100 mg/mL (182.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37. [Content Brief]
[2]. Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21(9):2409-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8292 mL | 9.1458 mL | 18.2916 mL | 45.7289 mL |
| 5 mM | 0.3658 mL | 1.8292 mL | 3.6583 mL | 9.1458 mL | |
| 10 mM | 0.1829 mL | 0.9146 mL | 1.8292 mL | 4.5729 mL | |
| 15 mM | 0.1219 mL | 0.6097 mL | 1.2194 mL | 3.0486 mL | |
| 20 mM | 0.0915 mL | 0.4573 mL | 0.9146 mL | 2.2864 mL | |
| 25 mM | 0.0732 mL | 0.3658 mL | 0.7317 mL | 1.8292 mL | |
| 30 mM | 0.0610 mL | 0.3049 mL | 0.6097 mL | 1.5243 mL | |
| 40 mM | 0.0457 mL | 0.2286 mL | 0.4573 mL | 1.1432 mL | |
| 50 mM | 0.0366 mL | 0.1829 mL | 0.3658 mL | 0.9146 mL | |
| 60 mM | 0.0305 mL | 0.1524 mL | 0.3049 mL | 0.7621 mL | |
| 80 mM | 0.0229 mL | 0.1143 mL | 0.2286 mL | 0.5716 mL | |
| 100 mM | 0.0183 mL | 0.0915 mL | 0.1829 mL | 0.4573 mL |
Anamorelin Related Classifications
HY-14734 Related Classifications
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