Anamorelin hydrochloride
Based on 11 publication(s) in Google Scholar
Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 861998-00-7
- Formula: C31H43ClN6O3
- Molecular Weight:583.16
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Anamorelin hydrochloride
More- J Cachexia Sarcopenia Muscle. 2026 Jun;17(3):e70318. [Abstract]
- J Sep Sci. 2016 Jan;39(2):333-41. [Abstract]
- J Pharm Biomed Anal. 2016 Nov 30:131:482-496. [Abstract]
- Discov Med. 2024 Sep 17.
- Drug Test Anal. 2021 Feb;13(2):283-298. [Abstract]
- Mass Spectrom Lett. 2016, 7(3):55-63.
- Mass Spectrom Lett. 2016 Sep 30;7(3):55-63.
- Patent. US20240197718A1.
- Patent. US20240197718A1.
- Patent. US20240139176A1.
- Universität Zürich. 2023 Jun 14.
Biological Activity
Ki: 0.7 nM (Ghrelin receptor)[1]
EC50: 0.74 nM (Ghrelin receptor)[1]
Anamorelin (0.01 nM-10 μM; 15 min) hydrochloride stimulates growth hormone release in a dose-dependent manner in rat pituitary cells, with an EC50 of 1.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anamorelin (3.5 mg/kg; oral administration; 1-7 days) hydrochloride significantly elevates the levels of growth hormone and insulin-like growth factor-1 in pigs[1].
Anamorelin (3-30 mg/kg; oral administration; 28 days) hydrochloride does not promote tumor growth in a nude mouse model of lung cancer xenografts, but increases the body weight of nude mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice (nu/nu, Harlan) (18.4-26.6 g, 9-10 weeks old) treated A549 cells[2]
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Dosage:3, 10 and 30 mg/kg
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Administration:Oral administration (p.o.); 28 day
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Result:Did not promote tumor growth in the murine NSCLC xenograft model.
Significantly increased the percentage of mean body weight gain at the end of treatment at doses of 10 and 30 mg/kg compared with controls.
Significantly increased peak plasma levels of murine growth hormone (mGH), while peak murine insulin-like growth factor-1 (mIGF-1) levels were slightly elevated but not statistically significant.
Were well tolerated.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 861998-00-7
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Appearance Solid
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Molecular Weight 583.16
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Formula C31H43ClN6O3
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Color White to off-white
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SMILES
[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O.[H]Cl
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Synonyms
RC-1291 hydrochloride; ONO-7643 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (11)
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Journal Impact Factor
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Most Recent
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J Cachexia Sarcopenia Muscle
Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice. [Abstract]2026 Jun;17(3):e70318. PMID: 42223236 -
J Sep Sci
Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry. [Abstract]2016 Jan;39(2):333-41. PMID: 26578461 -
J Pharm Biomed Anal
Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry. [Abstract]2016 Nov 30:131:482-496. PMID: 27693991 -
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Drug Test Anal
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]2021 Feb;13(2):283-298. PMID: 32852861 -
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Solvent & Solubility
DMSO : ≥ 100 mg/mL (171.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (85.74 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37. [Content Brief]
[2]. Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21(9):2409-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 1.7148 mL | 8.5740 mL | 17.1480 mL | 42.8699 mL |
| 5 mM | 0.3430 mL | 1.7148 mL | 3.4296 mL | 8.5740 mL | |
| 10 mM | 0.1715 mL | 0.8574 mL | 1.7148 mL | 4.2870 mL | |
| 15 mM | 0.1143 mL | 0.5716 mL | 1.1432 mL | 2.8580 mL | |
| 20 mM | 0.0857 mL | 0.4287 mL | 0.8574 mL | 2.1435 mL | |
| 25 mM | 0.0686 mL | 0.3430 mL | 0.6859 mL | 1.7148 mL | |
| 30 mM | 0.0572 mL | 0.2858 mL | 0.5716 mL | 1.4290 mL | |
| 40 mM | 0.0429 mL | 0.2143 mL | 0.4287 mL | 1.0717 mL | |
| 50 mM | 0.0343 mL | 0.1715 mL | 0.3430 mL | 0.8574 mL | |
| 60 mM | 0.0286 mL | 0.1429 mL | 0.2858 mL | 0.7145 mL | |
| 80 mM | 0.0214 mL | 0.1072 mL | 0.2143 mL | 0.5359 mL | |
| DMSO | 100 mM | 0.0171 mL | 0.0857 mL | 0.1715 mL | 0.4287 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Anamorelin hydrochloride Related Classifications
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