Anamorelin Fumarate
Based on 11 publication(s) in Google Scholar
Anamorelin (RC-1291) Fumarate is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin Fumarate can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin Fumarate can be used in the research of anorexia and cancer cachexia.
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- CAS No.: 339539-92-3
- Formule: C35H46N6O7
- Masse moléculaire:662.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Anamorelin Fumarate
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-14734
AnamorelinGhrelin Receptor Agonist -
HY-14734A
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TC-G-1008GPR39 Agonist -
HY-14734R
Anamorelin (Standard)Standard of Anamorelin -
HY-12584
PF-5190457GHSR Inverse Agonist -
HY-U00433
JMV 2959 -
HY-108699
TM-N1324GPR39 Agonist -
HY-P0231
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HY-19884B
Relamorelin TFAGHSR Agonist -
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Macimorelin acetateGHSR Agonist
Publications Citing Use of MedChemExpress (MCE) Anamorelin Fumarate
More- J Cachexia Sarcopenia Muscle. 2026 Jun;17(3):e70318. [Abstract]
- J Sep Sci. 2016 Jan;39(2):333-41. [Abstract]
- J Pharm Biomed Anal. 2016 Nov 30:131:482-496. [Abstract]
- Discov Med. 2024 Sep 17.
- Drug Test Anal. 2021 Feb;13(2):283-298. [Abstract]
- Mass Spectrom Lett. 2016, 7(3):55-63.
- Mass Spectrom Lett. 2016 Sep 30;7(3):55-63.
- Patent. US20240197718A1.
- Patent. US20240197718A1.
- Patent. US20240139176A1.
- Universität Zürich. 2023 Jun 14.
Activité biologique
Description
IC50 & Target
Ki: 0.7 nM (Ghrelin receptor)[1]
EC50: 0.74 nM (Ghrelin receptor)[1]
In Vitro
Anamorelin (0.01 nM-10 μM; 15 min) Fumarate stimulates growth hormone release in a dose-dependent manner in rat pituitary cells, with an EC50 of 1.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anamorelin (3.5 mg/kg; oral administration; 1-7 days) Fumarate significantly elevates the levels of growth hormone and insulin-like growth factor-1 in pigs[1].
Anamorelin (3-30 mg/kg; oral administration; 28 days) Fumarate does not promote tumor growth in a nude mouse model of lung cancer xenografts, but increases the body weight of nude mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice (nu/nu, Harlan) (18.4-26.6 g, 9-10 weeks old) treated A549 cells[2]
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Dosage:3, 10 and 30 mg/kg
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Administration:Oral administration (p.o.); 28 days
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Result:Did not promote tumor growth in the murine NSCLC xenograft model.
Significantly increased the percentage of mean body weight gain at the end of treatment at doses of 10 and 30 mg/kg compared with controls.
Significantly increased peak plasma levels of murine growth hormone (mGH), while peak murine insulin-like growth factor-1 (mIGF-1) levels were slightly elevated but not statistically significant.
Were well tolerated.
Chemical Information
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CAS No. 339539-92-3
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Masse moléculaire 662.78
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Formule C35H46N6O7
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SMILES
[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O.O=C(O)/C=C/C(O)=O
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Synonyms
RC-1291 Fumarate; ONO-7643 Fumarate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (11)
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Journal Impact Factor
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Most Recent
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J Cachexia Sarcopenia Muscle
Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice. [Abstract]2026 Jun;17(3):e70318. PMID: 42223236 -
J Sep Sci
Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry. [Abstract]2016 Jan;39(2):333-41. PMID: 26578461 -
J Pharm Biomed Anal
Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry. [Abstract]2016 Nov 30:131:482-496. PMID: 27693991 -
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Drug Test Anal
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]2021 Feb;13(2):283-298. PMID: 32852861 -
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Pureté et documentation
Références
[1]. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37. [Content Brief]
[2]. Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21(9):2409-15. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anamorelin Fumarate Related Classifications
HY-14734B Related Classifications
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