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Cat. No.: HY-162108

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Antitumor agent-128

Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells.

For research use only. We do not sell to patients.

CAS No.: 1942910-49-7
Formula: C₁₈H₉N₃O₂
Molecular Weight:299.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-128 Chemical Structure

CAS No.: 1942910-49-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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References
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Biological Activity

Description

Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.25 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 38169246]
A549	IC₅₀	0.34 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38169246]
A549	IC₅₀	0.34 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38169246]
A549	IC₅₀	0.43 μM Compound: 1a	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 38169246]
HCT-116	IC₅₀	25.22 μM Compound: 1a	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38169246]
MDA-MB-231	IC₅₀	3.54 μM Compound: 1a	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38169246]

Chemical Information

CAS No. 1942910-49-7
Molecular Weight 299.28
Formula C₁₈H₉N₃O₂
SMILES

O=C1N2C(C(C3=C2C=CC=C3)=O)=NC4=NC5=CC=CC=C5C=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bao-Long Hou, et al. Natural products fragment-based design and synthesis of a novel pentacyclic ring system as potential MAPK inhibitor. Bioorg Med Chem Lett. 2023 Dec 31:99:129598. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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