1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. CM10

CM10 

Cat. No.: HY-135841
Handling Instructions

CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.

For research use only. We do not sell to patients.

CM10 Chemical Structure

CM10 Chemical Structure

CAS No. : 692269-09-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1].

IC50 & Target

IC50: 1700 nM (ALDH1A1), 740 nM (ALDH1A2) and 640 nM (ALDH1A3)[1]

In Vitro

CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs)[1].
CM10 induces a cellular/nuclear swelling necroptotic phenotype[1].

Molecular Weight

321.42

Formula

C₂₀H₂₃N₃O

CAS No.

692269-09-3

SMILES

OC1=C(CNC2=NC3=CC=CC=C3N2CCC)C=CC=C1CC=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CM10CM 10CM-10Aldehyde Dehydrogenase (ALDH)AldehydedehydrogenaseALDH1AiALDH1A1ALDH1A2ALDH1A3metabolismanti-cancerInhibitorinhibitorinhibit

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