1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. CM10

CM10 

Cat. No.: HY-135841 Purity: 99.53%
Handling Instructions

CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.

For research use only. We do not sell to patients.

CM10 Chemical Structure

CM10 Chemical Structure

CAS No. : 692269-09-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1].

IC50 & Target

IC50: 1700 nM (ALDH1A1), 740 nM (ALDH1A2) and 640 nM (ALDH1A3)[1]

In Vitro

CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs)[1].
CM10 induces a cellular/nuclear swelling necroptotic phenotype[1].

Molecular Weight

321.42

Formula

C₂₀H₂₃N₃O

CAS No.

692269-09-3

SMILES

OC1=C(CNC2=NC3=CC=CC=C3N2CCC)C=CC=C1CC=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (388.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1112 mL 15.5560 mL 31.1119 mL
5 mM 0.6222 mL 3.1112 mL 6.2224 mL
10 mM 0.3111 mL 1.5556 mL 3.1112 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CM10CM 10CM-10Aldehyde Dehydrogenase (ALDH)AldehydedehydrogenaseALDH1AiALDH1A1ALDH1A2ALDH1A3metabolismanti-cancerInhibitorinhibitorinhibit

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CM10
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HY-135841
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