1. Anti-infection Autophagy Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Parasite Autophagy Apoptosis Reactive Oxygen Species Antibiotic
  3. Avermectin B1

Avermectin B1  (Synonyms: Abamectin; Avermectin B1a-Avermectin B1b mixt.)

Cat. No.: HY-15311 Purity: 98.36%
COA Handling Instructions

Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy.

For research use only. We do not sell to patients.

Avermectin B1 Chemical Structure

Avermectin B1 Chemical Structure

CAS No. : 71751-41-2

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10 mM * 1 mL in DMSO
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy[1][2][4].

In Vitro

Avermectin B1 (0-80 μM, 12 h) induces cytotoxicity through MAPK and ATM/ATR pathway in mouse embryonic fibroblast (MEF) cells, and induces ROS-mediated DNA damage[1].
Avermectin B1 (36 μg/mL, 72 h) has strong nematicidal efect of on G. pallida in aqueous solution, and negatively influences viability and infectivity of G. pallida J2 detected in potato roots(cv. Spunta)[2].
Abamectin (10 μM, 24 h) induces significant cytotoxicity by overproduction of ROS in haemocytes of Erocheir sinensis[3].
Abamectin (4 μM, 24 h) induces apoptosis and autophagy by inhibiting ROS-mediated PI3K/AKT signaling in MGC803 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Mouse embryonic fibroblast (MEF) cells
Concentration: 0, 0.5, 5, 10, 20, 40, 80 μM
Incubation Time: 12 h
Result: Reduced cell viability with an IC50 value of 45.6 μM.

Western Blot Analysis[3]

Cell Line: MGC803 cells
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Increased active caspase-3 and expression of Bax/Bcl-2, decreased MMP in a dose-dependent manner.
In Vivo

Avermectin B1 (oral administration, 0.2 mg/kg for a single dose) is highly efficacious against intestinal strongyles and Onchocera microfilaria in horses[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Horses (had a pruritic dermatosis)[5]
Dosage: 0.2 mg/kg, a single dose.
Administration: Oral administration
Result: Decreased in mean strongyle egg counts 14, 28 and 42 d after treatment, and resulted in zero microfilaria counts in all horses 14 d after treatment.
Animal Model: Healthy adult female sheep (Pharmacokinetic assay)[6]
Dosage: 0.2 mg/kg
Administration: Subcutaneous administration (in the left neck area of each sheep)
Result: Pharmacokinetic profiles of Avermectin B1
Parameters Mean
Kcl (/day) 0.17
t1/2cl (day) 4.36
Kab (/day) 0.24
t1/2ab (day) 3.15
Cmax (ng/mL) 6.24
tmax (day) 4.20
AUC (0-27) (ng/day/mL) 80.2
AUC(0-∞) (ng/day/mL) 84.7
MRT (day) 8.80
Clinical Trial
Molecular Weight

873.09

Formula

C48H72O14 (for Avermectin B1a)

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](CC)[C@]1([H])[C@@H](C)C=C[C@@]2(O[C@@]3([H])C[C@]([H])(OC([C@@]4([H])[C@@](/C(CO5)=C/C=C/[C@H](C)[C@H](O[C@@]6([H])C[C@H](OC)[C@@H](O[C@]7([H])O[C@@H](C)[C@H](O)[C@@H](OC)C7)[C@H](C)O6)/C(C)=C/C3)(O)[C@@]5([H])[C@H](O)C(C)=C4)=O)C2)O1.C[C@H]8C=C[C@@]9(O[C@@]%10([H])C[C@]([H])(OC([C@@]%11([H])[C@@](/C(CO%12)=C/C=C/[C@H](C)[C@H](O[C@@]%13([H])C[C@H](OC)[C@@H](O[C@]%14([H])O[C@@H](C)[C@H](O)[C@@H](OC)C%14)[C@H](C)O%13)/C(C)=C/C%10)(O)[C@@]%12([H])[C@H](O)C(C)=C%11)=O)C9)O[C@@H]8C(C)C

Structure Classification
Initial Source

Streptomyces avermitilis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (286.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1454 mL 5.7268 mL 11.4536 mL
5 mM 0.2291 mL 1.1454 mL 2.2907 mL
10 mM 0.1145 mL 0.5727 mL 1.1454 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (2.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.08 mg/mL (2.38 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (2.38 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Avermectin B1
Cat. No.:
HY-15311
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