1. Anti-infection
    Autophagy
    Apoptosis
    NF-κB
    Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Parasite
    Autophagy
    Apoptosis
    Reactive Oxygen Species
  3. Avermectin B1

Avermectin B1 (Synonyms: Abamectin; Avermectin B1a-Avermectin B1b mixt.)

Cat. No.: HY-15311 Purity: 96.89%
Handling Instructions

Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy.

For research use only. We do not sell to patients.

Avermectin B1 Chemical Structure

Avermectin B1 Chemical Structure

CAS No. : 71751-41-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 68 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 68 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 62 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy[1][2][4].

In Vitro

Avermectin B1 (0-80 μM, 12 h) induces cytotoxicity through MAPK and ATM/ATR pathway in mouse embryonic fibroblast (MEF) cells, and induces ROS-mediated DNA damage[1].
Avermectin B1 (36 μg/mL, 72 h) has strong nematicidal efect of on G. pallida in aqueous solution, and negatively influences viability and infectivity of G. pallida J2 detected in potato roots(cv. Spunta)[2].
Abamectin (10 μM, 24 h) induces significant cytotoxicity by overproduction of ROS in haemocytes of Erocheir sinensis[3].
Abamectin (4 μM, 24 h) induces apoptosis and autophagy by inhibiting ROS-mediated PI3K/AKT signaling in MGC803 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Mouse embryonic fibroblast (MEF) cells
Concentration: 0, 0.5, 5, 10, 20, 40, 80 μM
Incubation Time: 12 h
Result: Reduced cell viability with an IC50 value of 45.6 μM.

Western Blot Analysis[3]

Cell Line: MGC803 cells
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Increased active caspase-3 and expression of Bax/Bcl-2, decreased MMP in a dose-dependent manner.
In Vivo

Avermectin B1 (oral administration, 0.2 mg/kg for a single dose) is highly efficacious against intestinal strongyles and Onchocera microfilaria in horses[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Horses (had a pruritic dermatosis)[5]
Dosage: 0.2 mg/kg, a single dose.
Administration: Oral administration
Result: Decreased in mean strongyle egg counts 14, 28 and 42 d after treatment, and resulted in zero microfilaria counts in all horses 14 d after treatment.
Animal Model: Healthy adult female sheep (Pharmacokinetic assay)[6]
Dosage: 0.2 mg/kg
Administration: Subcutaneous administration (in the left neck area of each sheep)
Result: Pharmacokinetic profiles of Avermectin B1
Parameters Mean
Kcl (/day) 0.17
t1/2cl (day) 4.36
Kab (/day) 0.24
t1/2ab (day) 3.15
Cmax (ng/mL) 6.24
tmax (day) 4.20
AUC (0-27) (ng/day/mL) 80.2
AUC(0-∞) (ng/day/mL) 84.7
MRT (day) 8.80
Clinical Trial
Molecular Weight

1732.13

Formula

C95H142O28

CAS No.
SMILES

C[[email protected]@H](CC)[[email protected]]1([H])[[email protected]@H](C)C=C[[email protected]@]2(O[[email protected]@]3([H])C[[email protected]]([H])(OC([[email protected]@]4([H])[[email protected]@](/C(CO5)=C/C=C/[[email protected]](C)[[email protected]](O[[email protected]@]6([H])C[[email protected]](OC)[[email protected]@H](O[[email protected]]7([H])O[[email protected]@H](C)[[email protected]](O)[[email protected]@H](OC)C7)[[email protected]](C)O6)/C(C)=C/C3)(O)[[email protected]@]5([H])[[email protected]](O)C(C)=C4)=O)C2)O1.C[[email protected]]8C=C[[email protected]@]9(O[[email protected]@]%10([H])C[[email protected]]([H])(OC([[email protected]@]%11([H])[[email protected]@](/C(CO%12)=C/C=C/[[email protected]](C)[[email protected]](O[[email protected]@]%13([H])C[[email protected]](OC)[[email protected]@H](O[[email protected]]%14([H])O[[email protected]@H](C)[[email protected]](O)[[email protected]@H](OC)C%14)[[email protected]](C)O%13)/C(C)=C/C%10)(O)[[email protected]@]%12([H])[[email protected]](O)C(C)=C%11)=O)C9)O[[email protected]@H]8C(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 247 mg/mL (142.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5773 mL 2.8866 mL 5.7732 mL
5 mM 0.1155 mL 0.5773 mL 1.1546 mL
10 mM 0.0577 mL 0.2887 mL 0.5773 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (1.44 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (1.44 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.44 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Avermectin B1
Cat. No.:
HY-15311
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