2. GPCR/G Protein
  3. Vasopressin Receptor
  4. Balovaptan

Balovaptan  (Synonyms: RG7314)

Cat. No.: HY-109024 Purity: 99.25%
COA Handling Instructions

Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

For research use only. We do not sell to patients.

Balovaptan Chemical Structure

Balovaptan Chemical Structure

CAS No. : 1228088-30-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 318 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 318 In-stock
Solid
5 mg USD 352 In-stock
10 mg USD 605 In-stock
25 mg USD 1089 In-stock
50 mg USD 1815 In-stock
100 mg USD 2475 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

IC50 & Target

Ki: 1 nM (hV1a), 39 nM (mV1a)[1]
In Vitro

Balovaptan (RG7314) shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

409.91

Appearance

Solid

Formula

C22H24ClN5O
CAS No.
SMILES

CN1CC2=NN=C([[email protected]]3CC[[email protected]](OC4=NC=CC=C4)CC3)[[email protected]]2[[email protected]]5=CC=C(Cl)C=C5C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (152.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4396 mL 12.1978 mL 24.3956 mL
5 mM 0.4879 mL 2.4396 mL 4.8791 mL
10 mM 0.2440 mL 1.2198 mL 2.4396 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Balovaptan1228088-30-9RG7314RG 7314RG-7314Vasopressin ReceptorInhibitorinhibitorinhibit

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