STING agonist-16
Based on 1 publication(s) in Google Scholar
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 96.71%
- CAS. Nr.: 652142-94-4
- Formel: C19H11Cl2N5O
- Molecular Weight:396.23
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-145010
SN-011STING Inhibitor -
HY-131454
SR-717STING Agonist -
HY-112921B
diABZI STING agonist-1 trihydrochlorideSTING Receptor Agonist -
HY-147010
STING agonist-12STING Activator -
HY-112921
diABZI STING agonist-1 (tautomerism)STING Agonist -
HY-138682
STING-IN-2STING Inhibitor -
HY-112693
H-151STING Antagonist -
HY-112906
C-176STING Inhibitor -
HY-136927
MSA-2STING Agonist -
HY-162465
BDW568STINGA230 Activator -
HY-112921A
diABZI STING agonist-1STING Agonist -
HY-138683
STING-IN-3STING Inhibitor
Publications Citing Use of MedChemExpress (MCE) STING agonist-16
More
Biologische Aktivität
Beschreibung
In Vitro
STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1)[1].
STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells[1].
STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC50 value of 16.77 μM while 2'3'-cGAMP acts with an EC50 value of 9.212 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS. Nr. 652142-94-4
-
Appearance Solid
-
Molecular Weight 396.23
-
Formel C19H11Cl2N5O
-
Color Off-white to light brown
-
SMILES
COC1=CC=C2N=C(Cl)C(C3=NN=C4N3C5=C(C=CC=C5)N=C4Cl)=CC2=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Biomater Res
2026 Jan 23:30:0300. PMID: 41583068
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 5 mg/mL (12.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
-
Data Sheet (279 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5238 mL | 12.6189 mL | 25.2379 mL | 63.0947 mL |
| 5 mM | 0.5048 mL | 2.5238 mL | 5.0476 mL | 12.6189 mL | |
| 10 mM | 0.2524 mL | 1.2619 mL | 2.5238 mL | 6.3095 mL |
STING agonist-16 Related Classifications
HY-131994 Related Classifications
Powered by Bioz