2. Immunology/Inflammation
  3. STING
  4. STING agonist-16

STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool.

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STING agonist-16 Chemical Structure

STING agonist-16 Chemical Structure

CAS No. : 652142-94-4

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Based on 1 publication(s) in Google Scholar

STING agonist-16 Related Antibodies

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Description

STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool[1].
In Vitro

STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1)[1].
STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells[1].
STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC50 value of 16.77 μM while 2'3'-cGAMP acts with an EC50 value of 9.212 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-16 Related Antibodies
Molecular Weight

396.23

Formula

C19H11Cl2N5O
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

COC1=CC=C2N=C(Cl)C(C3=NN=C4N3C5=C(C=CC=C5)N=C4Cl)=CC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5238 mL 12.6189 mL 25.2379 mL
5 mM 0.5048 mL 2.5238 mL 5.0476 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥99.0%

COA (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5238 mL 12.6189 mL 25.2379 mL 63.0947 mL
5 mM 0.5048 mL 2.5238 mL 5.0476 mL 12.6189 mL
10 mM 0.2524 mL 1.2619 mL 2.5238 mL 6.3095 mL
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STING agonist-16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-16652142-94-4STING agonist16STING agonist 16STINGStimulator of Interferon GenesTMEM173MITAERISMPYSstimulator of interferon genesantiviralantitumorInhibitorinhibitorinhibit

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STING agonist-16
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