Anti-Mouse Ly6G Antibody (1A8) 

Anti-Mouse Ly6G Antibody (1A8) is a rat-derived anti-mouse Ly6G IgG2a, κ type antibody inhibitor. Anti-Mouse Ly6G Antibody (1A8) can deplete neutrophil in various mice. Anti-Mouse Ly6G Antibody (1A8) can be used for the researches of inflammation, such as arthritis and peritonitis^[1][2].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

Ly6G

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Ly6G Antibody (1A8) (25-100 µg, i.p., 3 times a week) induces neutrophil depletion in various mice, including C57Bl6/J and IMR32 tumor bearing SCID mice^[1].
Anti-Mouse Ly6G Antibody (1A8) (5 µg, i.p., 1 day before arthritis induction and again at day 2) abrogates arthritis in IgG immune complex-mediated K/BxN serum transfer arthritis mice models^[2].
Anti-Mouse Ly6G Antibody (1A8) (5 µg, i.p., 5 days before and once again 3 days before peritonitis) inhibits integrin-mediated neutrophil migration in peritonitis mice model induced by IL-1β^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

546644  [NCBI]

P35461

in vivo neutrophil depletion; in vivo MDSC depletion; Immunofluorescence; Immunohistochemistry (p

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse Ly6G Antibody (1A8)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Olofsen PA, et al. Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody. Cells. 2022 Oct 27;11(21):3406.  [Content Brief]

  [2]. Pierre Cunin, et al. Differential attenuation of β2 integrin–dependent and –independent neutrophil migration by Ly6G ligation. Blood Adv (2019) 3 (3): 256–267.