Anti-Mouse Ly6G Antibody (1A8)
Based on 1 publication(s) in Google Scholar
Anti-Mouse Ly6G Antibody (1A8) is a rat-derived anti-mouse Ly6G IgG2a, κ type antibody inhibitor. Anti-Mouse Ly6G Antibody (1A8) can deplete neutrophil in various mice. Anti-Mouse Ly6G Antibody (1A8) can be used for the researches of inflammation, such as arthritis and peritonitis[2].
For research use only. We do not sell to patients.
- Purity: 99.54%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse Ly6G Antibody (1A8)
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Biological Activity
Rat IgG2a kappa
Mouse
Ly6G
The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse Ly6G Antibody (1A8) (5 µg, i.p., 1 day before arthritis induction and again at day 2) abrogates arthritis in IgG immune complex-mediated K/BxN serum transfer arthritis mice models[2].
Anti-Mouse Ly6G Antibody (1A8) (5 µg, i.p., 5 days before and once again 3 days before peritonitis) inhibits integrin-mediated neutrophil migration in peritonitis mice model induced by IL-1β[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl6/J, Balb/c, NXG, and SCID mice (>20 weeks)[1]
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Dosage:25 and 100 µg
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Administration:Intraperitoneally injection, 3 times a week
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Result:Efficiently depleted neutrophils.
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Animal Model:SCID mice were injected with IMR32 cells in a 1:2 mix with Vitrogel Hydrogel Matrix[1]
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Dosage:100 µg
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Administration:Intraperitoneally injection, 3 times a week
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Result:Showed complete neutrophil depletion.
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Animal Model:IgG immune complex-mediated K/BxN serum transfer arthritis mice models[2]
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Dosage:5 µg
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Administration:Intraperitoneally injection, 1 day before arthritis induction and again at day 2
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Result:Abrogated arthritis.
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Animal Model:Peritonitis model induced by IL-1β[2]
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Dosage:5 µg
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Administration:Intraperitoneally injection, 5 days before and once again 3 days before peritonitis
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Result:Altered the ratio of WT-to-CD18-/- migrated neutrophils.
546644 [NCBI]
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo neutrophil depletion; in vivo MDSC depletion; Immunofluorescence; IHC-P
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse Ly6G Antibody (1A8)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Ly6G Antibody (1A8) Related Classifications
HY-P990118 Related Classifications
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