PPP1R1A Protein, Human (His)
PPP1R1A Protein, Human (His) is the recombinant human-derived PPP1R1A protein, expressed by E. coli, with C-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
PPP1R1A Protein, Human (His) is the recombinant human-derived PPP1R1A protein, expressed by E. coli, with C-6*His labeled tag.
Background
Protein phosphatase 1 regulatory subunit 1A is a potent inhibitor of protein phosphatase 1 (PP1). PPP1R1A plays an important role in the hormonal control of glycogen metabolism. Hormones that raise intracellular cAMP increase I-1 activity in many tissues. I-1 activation may enable cAMP to control proteins that are not directly phosphorylated by PKA. As intracellular calcium rises, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type 2 phosphatase. PPP1R1A may regulate activation of PI3K-Akt pathway, cell cycle, glycogen metabolism, and recruitment of M2 macrophages in liver cancer. PPP1R1A regulates GLR1R-mediated expansion of glucose-stimulated insulin secretion in beta cells. Inhibition of PKA/PPP1R1A/PP1 pathway has potential therapeutic value in the treatment of both primary and metastatic Ewing's sarcoma (ES)[1][2][3][4].
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
AAH22470.1 (M1-V171)
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Molecular Construction
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N-term
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PPP1R1A (M1-V171)
Accession # AAH22470.1 -
6*His
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C-term
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Protein Length
Full Length
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Synonyms
PPP1R1A; I-1; Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A; Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1A; Protein Phosphatase 1 Regulatory Subunit 1A; Protein Phosphatase Inhibitor-1; Protein Phosphatase Inhibitor 1; Inhibitor-1; IPP-
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AA Sequence
MEQDNSPQKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
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Predicted Molecular Mass
20 kDa
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Molecular Weight
Approximately 18 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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