PPP1R1A - protein phosphatase 1 regulatory inhibitor subunit 1A Gene

Also Known as I1; IPP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5502

About PPP1R1A

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,579,246-54,588,659 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 2 paralogues. Biased expression in fat (RPKM 174.0), kidney (RPKM 33.7) and 3 other tissues.

Summary

Predicted to enable protein serine/threonine Phosphatase Inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PPP1R1A Products (1)

mRNA Protein Name
NM_006741.4 NP_006732.3 protein phosphatase 1 regulatory subunit 1A

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11564868 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R1A Protein Structure

DARPP-32

DARPP-32: Protein phosphatase inhibitor 1/DARPP-32 (1 - 151)

  • 0
  • 100
  • 171 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 1A

  • I-1

PPP1R1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP1R1A Q13522 PPP1R15A Homo sapiens O75807
Y2H
11564868
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPP1R1A Proteins

Cat. No. Product Name Accession Purity
HY-P70987 PPP1R1A Protein, Human (His) AAH22470.1 (M1-V171) ≥ 90%, as determined by reducing SDS-PAGE.

PPP1R1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P83364 PPP1R1A Antibody (YA3109) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Simple Partial Epilepsy

  • Epilepsy, Simple Partial
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10992 PPP1R1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19094 Ppp1r1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25584 Ppp1r1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PPP1R1A VGNC VGNC:58287
Mus musculus PPP1R1A MGD MGI:1889595
Macaca mulatta PPP1R1A VGNC VGNC:76368
Felis catus PPP1R1A VGNC VGNC:69000
Bos taurus PPP1R1A VGNC VGNC:54472
Rattus norvegicus PPP1R1A RGD RGD:62018
Others PPP1R1A NCBI