1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. HEAT hydrochloride

HEAT hydrochloride (Synonyms: BE2254 hydrochloride)

Cat. No.: HY-100980
Handling Instructions

HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively.

For research use only. We do not sell to patients.

HEAT hydrochloride Chemical Structure

HEAT hydrochloride Chemical Structure

CAS No. : 30007-39-7

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Description

HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively[1][2].

In Vitro

BE2254 inhibits (-)-noradrenaline-mediated increases in gluconeogenesis with K,sub>B of 0.74 nM[2].
The alpha-1 selective antagonist [125I]BE2254 is used to specifically label a single class of binding sites with a dissociation constant of 131.0 pM and a maximal binding capacity of 17.6 fmol/mg of protein. Catecholamines compete for [125I]BE2254 binding stereospecifically and with the characteristic alpha adrenergic potency series of (-)-epinephrine greater than (-)-norepinephrine much greater than (-)-isoproterenol. The alpha-1 selective antagonist prazosin (Kd=2.4 nM) is much more potent in competing for [125I]BE2254 binding than is the alpha-2 selective antagonist yohimbine (Kd=2900 nM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

331.84

Formula

C₁₉H₂₂ClNO₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HEAT hydrochloride
Cat. No.:
HY-100980
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