30007-39-7
30007-39-7
Chemical Structure
HEAT hydrochloride
Synonym(s): BE2254 hydrochloride
- CAS No.: 30007-39-7
- Formula:C19H22ClNO2
- Molecular Weight:331.84
IUPAC Name: 2-(((4-hydroxyphenethyl)amino)methyl)-3,4-dihydronaphthalen-1(2H)-one hydrochloride
InChIKey: VCZXZECZIRGUCZ-UHFFFAOYSA-N
SMILES: O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3.Cl
Biological Activity: HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively[1][2].
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HEAT hydrochloride | HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively. | |||||||||||||||||||||
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References
- [1]. Chiu G, et al. Design and synthesis of an alpha1a-adrenergic receptor subtype-selective antagonist from BE2254. Chem Biol Drug Des. 2006;67(6):437-439. [Content Brief]
- [2]. McPherson GA, et al. A study of alpha 1-adrenoceptors in rat renal cortex: comparison of [3H]-prazosin binding with the alpha 1-adrenoceptor modulating gluconeogenesis under physiological conditions. Br J Pharmacol. 1982;77(1):177-184. [Content Brief]
Keywords
