BTN1A1 Protein, Human (HEK293, His-Avi)
BTN1A1 Protein is implicated in milk-fat droplet secretion and may serve as a membrane-associated receptor in lactation processes. Additionally, it exhibits immune-regulatory functions, inhibiting T-cell proliferation and modulating cytokine secretion. BTN1A1's association with xanthine dehydrogenase/oxidase suggests diverse cellular functions, inviting further exploration into its role in various biological pathways. BTN1A1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived BTN1A1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
BTN1A1 Protein is implicated in milk-fat droplet secretion and may serve as a membrane-associated receptor in lactation processes. Additionally, it exhibits immune-regulatory functions, inhibiting T-cell proliferation and modulating cytokine secretion. BTN1A1's association with xanthine dehydrogenase/oxidase suggests diverse cellular functions, inviting further exploration into its role in various biological pathways. BTN1A1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived BTN1A1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background
BTN1A1 Protein is suggested to play a role in the secretion of milk-fat droplets, indicating its potential involvement in the complex processes associated with lactation. Additionally, it may act as a specific membrane-associated receptor facilitating the association of cytoplasmic droplets with the apical plasma membrane, as suggested by similarity analyses. Moreover, BTN1A1 exhibits inhibitory effects on the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, impacting T-cell metabolism, and modulating the secretion of IL2 and IFNG, highlighting its potential role in immune regulation. Notably, BTN1A1 also appears to associate with xanthine dehydrogenase/oxidase, raising further questions about its diverse cellular functions and potential implications in various biological pathways.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-8*His
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Accession
Q13410 (A27-R242)
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Molecular Construction
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N-term
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BTN1A1 (A27-R242)
Accession # Q13410 -
8*His-Avi
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C-term
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Protein Length
Extracellular Domain
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Synonyms
BTN1A1; BTN1; Prev. BTN; BK14H9.2 (Butyrophilin, Subfamily 1, Member A1); BT; BTN1A1 Protein; Butyrophilin Subfamily 1 Member A1; Butyrophilin, Subfamily 1, Member A1
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AA Sequence
APFDVIGPPEPILAVVGEDAELPCRLSPNASAEHLELRWFRKKVSPAVLVHRDGREQEAEQMPEYRGRATLVQDGIAKGRVALRIRGVRVSDDGEYTCFFREDGSYEEALVHLKVAALGSDPHISMQVQENGEICLECTSVGWYPEPQVQWRTSKGEKFPSTSESRNPDEEGLFTVAASVIIRDTSAKNVSCYIQNLLLGQEKKVEISIPASSLPR
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Predicted Molecular Mass
26.9 kDa
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Molecular Weight
Approximately 30-40 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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