BTN1A1 - butyrophilin subfamily 1 member A1 Gene

Also Known as BT; BTN; BTN1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 696

About BTN1A1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,500,303-26,510,425 (from NCBI)

This gene has 2 transcripts (splice variants), 99 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]

BTN1A1 Products (1)

mRNA	Protein	Name
NM_001732.3	NP_001723.2	butyrophilin subfamily 1 member A1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN1A1 Protein Structure

V-set

C2-set_2

PRY

SPRY

0
100
200
300
400
500
526 a.a.

Protein Preferred Names	Protein Names
butyrophilin subfamily 1 member A1	bK14H9.2 (butyrophilin, subfamily 1, member A1)

BTN1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BTN1A1	Q13410	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	BTN1A1	Q13410	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	BTN1A1	Q13410	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	BTN1A1	Q13410	MOSPD2	Homo sapiens	Q8NHP6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7689	BTN1A1 Protein, Human (HEK293, His)	Q13410 (A27-R242)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70060	BTN1A1 Protein, Human (HEK293, Fc)	Q13410 (A27-R242)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72343	BTN1A1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13410 (A27-R242)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78395	BTN1A1 Protein, Human (HEK293, His-Avi)	Q13410 (A27-R242)	≥ 95%, as determined by Bis-Tris PAGE.

BTN1A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84538	BTN1A1 Antibody (YA4235)	WB, FC, ELISA	Human, Mouse, Rat
HY-P84538A	BTN1A1 Antibody (YA4235)(PBS only)	WB, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Tibial Neuropathy	Posterior Tibial Neuropathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990751	Nelmastobart	Inhibitor	95.437%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01670	BTN1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19248	Btn1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25737	Btn1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BTN1A1	VGNC	VGNC:60207
Rattus norvegicus	BTN1A1	RGD	RGD:1306984
Macaca mulatta	BTN1A1	VGNC	VGNC:70290
Bos taurus	BTN1A1	VGNC	VGNC:107283
Canis familiaris	BTN1A1	VGNC	VGNC:38562
Mus musculus	BTN1A1	MGD	MGI:103118
Others	BTN1A1	NCBI