1. Anti-infection
  2. Parasite

Avermectin B1a (Synonyms: Abamectin B1a)

Cat. No.: HY-15308 Purity: >95.0%
Handling Instructions

Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.

For research use only. We do not sell to patients.

Avermectin B1a Chemical Structure

Avermectin B1a Chemical Structure

CAS No. : 65195-55-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 887 In-stock
Estimated Time of Arrival: December 31
5 mg USD 462 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.

In Vitro

[3H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [3H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [3H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [3H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC50 values, 120 and 126 nM, respectively)[3]. AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations[4].

In Vivo

Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD50) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil[1]. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1454 mL 5.7269 mL 11.4537 mL
5 mM 0.2291 mL 1.1454 mL 2.2907 mL
10 mM 0.1145 mL 0.5727 mL 1.1454 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

873.08

Formula

C₄₈H₇₂O₁₄

CAS No.

65195-55-3

SMILES

C[[email protected]@H](CC)[[email protected]]1([H])[[email protected]@H](C)C=C[[email protected]@]2(O[[email protected]@]3([H])C[[email protected]]([H])(OC([[email protected]@]4([H])[[email protected]@](/C(CO5)=C/C=C/[[email protected]](C)[[email protected]](O[[email protected]@]6([H])C[[email protected]](OC)[[email protected]@H](O[[email protected]]7([H])O[[email protected]@H](C)[[email protected]](O)[[email protected]@H](OC)C7)[[email protected]](C)O6)/C(C)=C/C3)(O)[[email protected]@]5([H])[[email protected]](O)C(C)=C4)=O)C2)O1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Avermectin B1a
Cat. No.:
HY-15308
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Avermectin B1a

Cat. No.: HY-15308