2. Antibodies
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  4. Monoclonal Antibodies Recombinant Antibodies
  5. PTF1A Antibody (YA1707)

PTF1A Antibody (YA1707)

Art. -Nr.: HY-P81962
User Guide for Antibodies Technical Support

PTF1A Antibody (YA1707) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTF1A.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

Beschreibung

PTF1A Antibody (YA1707) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTF1A.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molekulargewicht
Predicted band size: 35 kDa;
Observed band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein of mouse PTF1A
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Reinheit Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Transcription factor implicated in the cell fate determination in various organs (PubMed:11562365, PubMed:12185368, PubMed:15543146, PubMed:17075007, PubMed:9851981). Binds to the E-box consensus sequence 5'-CANNTG-3' (PubMed:11562365, PubMed:12185368, PubMed:9851981). Plays a role in early and late pancreas development and differentiation (PubMed:11562365, PubMed:21852532). Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates (PubMed:11562365, PubMed:12185368, PubMed:9851981). May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase (PubMed:11562365, PubMed:12185368, PubMed:9851981). Required for the formation of pancreatic acinar and ductal cells (PubMed:11562365). Plays an important role in cerebellar development (PubMed:15543146). Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates (PubMed:17075007)
Subcellular Localization：Nucleus; Cytoplasm
Expression：
Tissue_specificity:Expressed in precursors of pancreatic islets, acini and ducts
Subunit：Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex. Interacts with TCF3 and RBPSUH/RBP-Jkappa
Database

Entrez Gene: 256297 Human ; 19213 Mouse ; 117034 Rat

SwissProt: Q7RTS3 Human ; Q9QX98 Mouse ; Q64305 Rat

OMIM: 607194 Human

Research Field

Neuroscience
Synonyms
Pancreas-specific transcription factor 1a; bHLH transcription factor p48; PTF1-p48
Dokumentation
User Guide for Antibodies (1077 KB)

PTF1A Antibody (YA1707) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PTF1A Antibody (YA1707)
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