PTF1A Antibody (YA1707)
(Synonyms: Pancreas-specific transcription factor 1a; bHLH transcription factor p48; PTF1-p48)PTF1A Antibody (YA1707) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTF1A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
PTF1A Antibody (YA1707) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTF1A.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 35 kDa
Entrez Gene: 256297 Human ; 19213 Mouse ; 117034 Rat
SwissProt: Q7RTS3 Human ; Q9QX98 Mouse ; Q64305 Rat
OMIM: 607194 Human
Recombinant protein of mouse PTF1A
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PTF1A transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates[1][2][3][4][5][6].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:Expressed in precursors of pancreatic islets, acini and ducts -
Subunit
Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex. Interacts with TCF3 and RBPSUH/RBP-Jkappa
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SwissProt ID
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Synonyms
Pancreas-specific transcription factor 1a; bHLH transcription factor p48; PTF1-p48
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Research Field
Neuroscience
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