Copy Link Print Information

mGluR1 Antibody (YA3195)

(Synonyms: GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1)
Customer Review

Based on 1 Customer Validation

mGluR1 Antibody (YA3195) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to mGluR1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • mGluR1 Antibody (YA3195) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

mGluR1 Antibody (YA3195) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to mGluR1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 101 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 132 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human mGluR1 aa315-385.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3105561

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    The metabotropic glutamate receptor subtype 1 (mGluR1) is a G-protein coupled receptor that mediates excitatory neurotransmission by activating phospholipase C and subsequent intracellular Ca2+ signaling[1][2]. Mechanistically, mGluR1 primarily couples to the Gq/11 family, leading to inositol trisphosphate (IP3) -dependent Ca2+ release and modulation of postsynaptic excitability[3][4]. In cerebellar Purkinje cells, mGluR1a, the predominant isoform, localizes perisynaptically and facilitates long-term depression (LTD) and climbing fiber synapse elimination, whereas the shorter mGluR1b lacks the extended C-terminal domain, resulting in dispersed subcellular distribution and altered IP3R-mediated Ca2+ signaling[1]. Compared with mGluR5, mGluR1 exhibits distinct pharmacology, including selective sensitivity to non-competitive antagonists like cyclothiazide and agonist potency dependent on the C-terminal domain[5][6]. In experimental disease models, mGluR1 expression is dynamically regulated in neurodegeneration and stress paradigms, contributing to synaptic plasticity deficits, excitotoxicity, and hippocampal signaling alterations[7][8]. Agonists and allosteric modulators of mGluR1 have been utilized to investigate synaptic transmission, motor coordination, and learning in rodent models, with subtype-selective agents enabling differentiation from mGluR5-mediated effects[9][10]. These characteristics make mGluR1 a critical target for dissecting group I mGluR function, understanding isoform-specific signaling, and designing pharmacological interventions in central nervous system studies[1][2][5].

  • Subcellular Localization

    Cell membrane; Multi-pass membrane protein; Postsynaptic cell membrane; Multi-pass membrane protein; Cell projection, dendrite

  • Expression


    Tissue_specificity:Detected in brain

  • Isoforms & Post-Translational Modification

    Q13255 has 3 isomers: Q13255-1: 132357 Da (predicted); Q13255-2: 101323 Da (predicted); Q13255-3: 101473 Da (predicted).

  • Subunit

    Homodimer; disulfide-linked (PubMed:24603153).

  • SwissProt ID

    Q13255

  • Gene ID
    2911 [NCBI]
  • Synonyms

    GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1

  • Research Field

    Neuroscience

References

[1]. Ohtani Y, et al. The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function. J Neurosci. 2014 Feb 12;34(7):2702-12. [Content Brief]

[2]. Flor PJ, et al. The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists. J Neurochem. 1996 Jul;67(1):58-63. [Content Brief]

[3]. Kumpost J, et al. Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells. Neuropharmacology. 2008 Sep;55(4):409-18. [Content Brief]

[4]. Sun YG, et al. mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus. J Neurosci. 2016 Jul 27;36(30):7886-96. [Content Brief]

[5]. Surin A, et al. Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists. Neuropharmacology. 2007 Mar;52(3):744-54. [Content Brief]

[6]. Mary S, et al. A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C. J Biol Chem. 1998 Jan 2;273(1):425-32. [Content Brief]

[7]. Dyka FM, et al. Metabotropic glutamate receptors are differentially regulated under elevated intraocular pressure. J Neurochem. 2004 Jul;90(1):190-202. [Content Brief]

[8]. Wierońska JM, et al. Olfactory bulbectomy and amitriptyline treatment influences mGlu receptors expression in the mouse brain hippocampus. Pharmacol Rep. 2008 Nov-Dec;60(6):844-55. [Content Brief]

[9]. Gereau RW 4th, et al. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. J Neurosci. 1995 Oct;15(10):6879-89. [Content Brief]

[10]. Harbers M, et al. mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning. Cells. 2022 Jun 23;11(13):2004. [Content Brief]

View More

mGluR1 Antibody (YA3195) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • mGluR1 Antibody (YA3195) Product Image
    1/16
  • mGluR1 Antibody (YA3195) Product Image