CD1A Protein, Human (HEK293, His)
The CD1A protein is a key antigen-presenting molecule that binds self and non-self lipid and glycolipid antigens and presents them to T cell receptors on natural killer T cells. CD1A, as a B2M (beta-2-microglobulin) heterodimer, plays a central role in immune surveillance and regulation. CD1A Protein, Human (HEK293, His) is the recombinant human-derived CD1A protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CD1A protein is a key antigen-presenting molecule that binds self and non-self lipid and glycolipid antigens and presents them to T cell receptors on natural killer T cells. CD1A, as a B2M (beta-2-microglobulin) heterodimer, plays a central role in immune surveillance and regulation. CD1A Protein, Human (HEK293, His) is the recombinant human-derived CD1A protein, expressed by HEK293 , with C-His labeled tag.
Background
The CD1A protein stands as a pivotal antigen-presenting molecule with the unique capacity to bind both self and non-self lipid and glycolipid antigens, facilitating their presentation to T-cell receptors on natural killer T-cells. Operating as a heterodimer with B2M (beta-2-microglobulin), this protein plays a central role in immune surveillance and regulation. Its interaction with CD74 further underscores its significance in the intricate machinery of the immune system, highlighting its role in orchestrating T-cell responses to diverse antigens.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-8*His
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Accession
P06126 (D19-V300)
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Molecular Construction
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N-term
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CD1A (D19-V300)
Accession # P06126 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CD1A; Epidermal Dendritic Cell Marker CD1a; Prev. CD1; Cluster Of Differentiation 1 A; T-Cell Surface Glycoprotein CD1a; CD1A Protein; T-Cell Surface Antigen T6/Leu-6; FCB6; CD1A Antigen, A Polypeptide; HTA1; HTa1 Thymocyte Antigen; R4; CD1a Antigen; T6;
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AA Sequence
DGLKEPLSFHVTWIASFYNHSWKQNLVSGWLSDLQTHTWDSNSSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYAHELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIVLYWEHHSSV
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Predicted Molecular Mass
33.3 kDa
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Molecular Weight
Approximately 48-53 kDa & 13-14 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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