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  2. GHSR
  3. Relamorelin acetate

Relamorelin acetate (Synonyms: RM-131 acetate; BIM-28131 acetate)

Cat. No.: HY-19884A
Handling Instructions

Relamorelin (RM-131) acetate, a Ghrelin analog, is a potent ghrelin receptor agonist, with a Ki of 0.42 nM for GHS-1a. Relamorelin acetate can promote food intake and adiposity in mice. Relamorelin acetate can be used for the research of cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.

For research use only. We do not sell to patients.

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Relamorelin acetate Chemical Structure

Relamorelin acetate Chemical Structure

CAS No. : 1809080-14-5

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Description

Relamorelin (RM-131) acetate, a Ghrelin analog, is a potent ghrelin receptor agonist, with a Ki of 0.42 nM for GHS-1a. Relamorelin acetate can promote food intake and adiposity in mice. Relamorelin acetate can be used for the research of cachexia, gastroparesis, and gastric/intestinal dysmobility disorders[1][2][3].

IC50 & Target

Ki: 0.42 nM (GHS-1a)[1]

In Vitro

Relamorelin shows ∼3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1. 12 nM)[1].
Relamorelin is 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) as assessed in vitro by calcium mobilization[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Relamorelin (500 nmol/kg/day; continuous infusion for 5 days) increases the food intake and weight gain in rats[1].
Relamorelin (50-500 nmol/kg/day; continuous infusion for 5 days) decreases the loss of body mass and fat mass[1].
RM-131 (250-500 nmol/kg; a single s.c.) stimulates acute food intake in wt but not growth hormone secretagogue receptor (GHR) ko mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: F344/NTacfBR male rats implanted with tumor[1]
Dosage: 50, 500 nmol/kg/day
Administration: Continuous infusion at a rate of 0.5 μL/h for 5 d s.c.
Result: Resulted in an increase in food intake (tumor/saline 41.4 g, tumor/BIM-28131 72.5 g) and weight gain (tumor/saline -10.3%, tumor/BIM-28131 +19.5%).
Molecular Weight

851.02

Formula

C₄₅H₅₄N₈O₇S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RelamorelinRM-131BIM-28131RM131RM 131BIM28131BIM 28131GHSRGrowth hormone secretagogue receptorGhrelinghrelinGHS-1afoodintakeadipositycachexiagastroparesisgastricintestinaldysmobilityInhibitorinhibitorinhibit

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Relamorelin acetate
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HY-19884A
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