GCAP1 Protein, Human (sf9)

GCAP1 Proteinas, a pivotal regulator in the visual system, modulates retinal guanylyl cyclase activity based on intracellular calcium concentrations. Under low calcium, GCAP1 stimulates retinal guanylyl cyclase for dark state recovery in rod photoreceptors. Elevated calcium inhibits guanylyl cyclase activity, a crucial aspect of rod photoreceptor phototransduction. Additionally, GCAP1 may contribute to light response and recovery in cone photoreceptors under bright light. The protein's homodimeric structure enhances its regulatory capabilities in the visual signaling pathway. GCAP1 Protein, Human (sf9) is the recombinant human-derived GCAP1 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of GCAP1 Protein, Human (sf9) is 201 a.a., with molecular weight of ~20 kDa.

GCAP1 protein serves as a pivotal regulator in the visual system, exhibiting a dual role in modulating retinal guanylyl cyclase activity based on intracellular calcium concentrations. Under low free calcium ion conditions, GCAP1 stimulates retinal guanylyl cyclase, facilitating the recovery of the dark state in rod photoreceptors after exposure to light. Conversely, when the concentration of free calcium ions is elevated, GCAP1 inhibits guanylyl cyclase activity. This calcium-sensitive control mechanism represents a crucial aspect of the phototransduction process in rod photoreceptors. Additionally, GCAP1 may play a role in the light response and recovery of cone photoreceptors in bright light conditions. The protein functions as a homodimer, further contributing to its regulatory capabilities in the visual signaling pathway.

Human

Sf9 insect cells

Tag Free

P43080 (N-G&P, M1-G201)

118142757  [NCBI]

Approximately 20 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.