1. Metabolic Enzyme/Protease
  2. HCV Protease
  3. Filibuvir

Filibuvir 

Cat. No.: HY-10118 Purity: 98.09%
Handling Instructions

Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the “Thumb 2” pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM.

For research use only. We do not sell to patients.

Filibuvir Chemical Structure

Filibuvir Chemical Structure

CAS No. : 877130-28-4

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1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the “Thumb 2” pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM[1].

Molecular Weight

503.64

Formula

C₂₉H₃₇N₅O₃

CAS No.

877130-28-4

SMILES

O=C(O1)C(CC2=NN(C(C)=C3)C(N=C3C)=N2)=C(O)C[[email protected]@]1(C4CCCC4)CCC5=CC(CC)=NC(CC)=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Filibuvir
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