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Cat. No.: HY-144115

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A1AR antagonist 1

A1AR antagonist 1 (compound 18g) is a potent A₁ adenosine receptor (AR) antagonist with K_is of 2.08, 6.91, and 31.2 nM for hA1, hA2A and hA2B, respectively.

For research use only. We do not sell to patients.

CAS No.: 2760128-99-0
Formula: C₁₈H₁₄N₄O
Molecular Weight:302.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

A1AR antagonist 1 Chemical Structure

CAS No.: 2760128-99-0

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

A1AR antagonist 1 (compound 18g) is a potent A₁ adenosine receptor (AR) antagonist with K_is of 2.08, 6.91, and 31.2 nM for hA1, hA2A and hA2B, respectively^[1].

All Adenosine Receptor Isoforms :

Chemical Information

CAS No. 2760128-99-0
Molecular Weight 302.33
Formula C₁₈H₁₄N₄O
SMILES

NC1=NC(C2=CC(OC)=CC=C2)=C(C(C3=CC=CC=C3)=N1)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Val C, et al. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists. J Med Chem. 2022;65(3):2091-2106. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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