2. Recombinant Proteins
  3. Cytokines and Growth Factors Biotinylated Proteins
  4. TNF Superfamily
  5. TNF Superfamily Ligands
  6. TL1A
  7. TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi)

TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi)

Cat. No.: HY-P700839
Handling Instructions

TL1A/TNFSF15 Protein, a receptor for TNFRSF25 and TNFRSF6B, crucially activates NF-kappa-B signaling. It promotes caspase activation for apoptosis and exhibits anti-angiogenic properties, inhibiting vascular endothelial growth and angiogenesis in vitro. The protein contributes to splenocyte alloactivation, emphasizing its significance in immune responses. Functioning as a homotrimer, TL1A/TNFSF15 reflects its structural arrangement in these cellular processes. TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived TL1A/TNFSF15 protein, expressed by HEK293, with C-Avi, N-His labeled tag. The total length of TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi) is 192 a.a., with molecular weight of 30-38 kDa.

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Description

TL1A/TNFSF15 Protein, a receptor for TNFRSF25 and TNFRSF6B, crucially activates NF-kappa-B signaling. It promotes caspase activation for apoptosis and exhibits anti-angiogenic properties, inhibiting vascular endothelial growth and angiogenesis in vitro. The protein contributes to splenocyte alloactivation, emphasizing its significance in immune responses. Functioning as a homotrimer, TL1A/TNFSF15 reflects its structural arrangement in these cellular processes. TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived TL1A/TNFSF15 protein, expressed by HEK293, with C-Avi, N-His labeled tag. The total length of TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi) is 192 a.a., with molecular weight of 30-38 kDa.
Background

The TL1A/TNFSF15 protein serves as the receptor for TNFRSF25 and TNFRSF6B, playing a crucial role in mediating the activation of NF-kappa-B signaling. Beyond its involvement in apoptosis by promoting the activation of caspases, TL1A/TNFSF15 exhibits anti-angiogenic properties, inhibiting vascular endothelial growth and angiogenesis in vitro. Furthermore, the protein contributes to splenocyte alloactivation, underscoring its significance in immune responses. TL1A/TNFSF15 functions as a homotrimer, reflecting its structural arrangement in these cellular processes.
Species

Mouse
Source

HEK293
Tag

N-His;N-Avi
Accession

Q5UBV8 (A61-L252)
Gene ID

326623  [NCBI]
Molecular Construction
N-term
His-Avi
TL1A (A61-L252)
Accession # Q5UBV8
C-term
Synonyms
TL1A; VEGI-251; TNFSF15; TL1; VEGI; VEGI192A
Molecular Weight

30-38 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TL1A/TNFSF15 Protein, Mouse (HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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