1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

Elbasvir (Synonyms: MK-8742)

Cat. No.: HY-15789 Purity: 99.97%
Handling Instructions

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.

For research use only. We do not sell to patients.

Elbasvir Chemical Structure

Elbasvir Chemical Structure

CAS No. : 1370468-36-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 175 In-stock
Estimated Time of Arrival: December 31
2 mg USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.

IC50 & Target

EC50: 4 nM (HCV 1a), 3 nM (HCV 1b), 3 nM (HCV 2a)[1]

In Vitro

Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC90 of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC90 of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses[1]. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC50s in the low-picomolar range[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1338 mL 5.6688 mL 11.3376 mL
5 mM 0.2268 mL 1.1338 mL 2.2675 mL
10 mM 0.1134 mL 0.5669 mL 1.1338 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

882.02

Formula

C₄₉H₅₅N₉O₇

CAS No.

1370468-36-2

SMILES

O=C([[email protected]](C(C)C)NC(OC)=O)N(CCC1)[[email protected]@H]1C(N2)=NC=C2C(C=C3)=CC4=C3C5=CC6=CC(C7=CN=C([[email protected]]8N(C([[email protected]](C(C)C)NC(OC)=O)=O)CCC8)N7)=CC=C6N5[[email protected]](C9=CC=CC=C9)O4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.97%

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Product Name:
Elbasvir
Cat. No.:
HY-15789
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Elbasvir

Cat. No.: HY-15789