1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

Elbasvir (Synonyms: MK-8742)

Cat. No.: HY-15789 Purity: 98.20%
Data Sheet SDS Handling Instructions

Elbasvir is a small-molecule inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.

For research use only. We do not sell to patients.
Elbasvir Chemical Structure

Elbasvir Chemical Structure

CAS No. : 1370468-36-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $146 In-stock
2 mg $80 In-stock
5 mg $110 In-stock
10 mg $150 In-stock
50 mg $490 In-stock
100 mg $850 In-stock
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500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Elbasvir is a small-molecule inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.

In Vitro

Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC90 of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC90 of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses[1]. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC50s in the low-picomolar range[2].

Clinical Trial
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References
Molecular Weight

882.02

Formula

C₄₉H₅₅N₉O₇

CAS No.

1370468-36-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Elbasvir
Cat. No.:
HY-15789
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