2. Apoptosis Neuronal Signaling Membrane Transporter/Ion Channel
  3. Caspase Apoptosis iGluR
  4. PEAQX

PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures.

It is advisable to consider the salt form (PEAQX tetrasodium hydrate) that retains the same biological activity.

For research use only. We do not sell to patients.

CAS No. : 459836-30-7

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PEAQX Related Antibodies

Top Publications Citing Use of Products

    PEAQX purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1:391:1-12.  [Abstract]

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.

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    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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    AMPA Receptor NMDA Receptor Kainate Receptor

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    Description

    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
    IC50 & Target

    NMDA Receptor

     

    In Vitro

    PEAQX (3 μM) can induce cell apoptosis and promote caspase-3 activation in cortical striatal slice cultures[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PEAQX Related Antibodies
    In Vivo

    PEAQX (10-40 mg/kg; s.c.) can increase caspase-3 activity and enhance motor activity in the frontal cortex and striatum of rats in a dose-dependent manner[2].
    PEAQX (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Pups obtained from deliveries of pregnant female Sprague-Dawley rats[2].
    Dosage: 10, 20, 40 mg/kg
    Administration: Subcutaneous injection (s.c.)
    Result: Resulted in an 8-fold increase in caspase-3 activity in the striatum when administered at a dose of 20 mg/kg.
    Animal Model: 11-week old C57BL/6 mice with cerebral ischemia[3].
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection (i.p.); once daily; 4 days
    Result: Reduced protein expression levels in the CaMKIV-TORC1-p-CREB-BDNF pathway.
    Molecular Weight

    454.21

    Formula

    C17H17BrN3O5P
    CAS No.
    SMILES

    O=C1C(NC2=C(C(C(P(O)(O)=O)N[C@H](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility

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    In Vivo:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      PEAQX is dissolved in DMSO and diluted with sterile saline[3].

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PEAQX459836-30-7NVP-AAM077CaspaseApoptosisiGluRIonotropic glutamate receptorsorally activeNMDAcaspase-3cerebral ischemialearning disorderInhibitorinhibitorinhibit

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