PEAQX tetrasodium hydrate
Based on 8 publication(s) in Google Scholar
PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures.
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- Pureté: 99.72%
- Formule: C17H15BrN3Na4O6P
- Masse moléculaire:560.15
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Neuronal Signaling Compound Library
HY-L013
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Covalent Screening Library
HY-L036
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Orally Active Compound Library
HY-L061
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Neurotransmitter Receptor Compound Library
HY-L062
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Anti-Alzheimer's Disease Compound Library
HY-L069
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Neuroprotective Compound Library
HY-L070
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Antidepressant Compound Library
HY-L108
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Pain-Related Compound Library
HY-L139
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Ion Channel Compound Library
HY-L166
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) PEAQX tetrasodium hydrate
More- J Clin Invest. 2019 Sep 3;129(9):3864-3876. [Abstract]
- Brain Behav Immun. 2026 Jul:135:106529. [Abstract]
- Neurosci Bull. 2025 Apr 28. [Abstract]
- Cells. 2023 Apr 22;12(9):1212. [Abstract]
- Front Neurosci. 2021 Sep 30:15:703044. [Abstract]
- Neuroscience. 2018 Nov 1:391:1-12. [Abstract]
- Am J Hypertens. 2021 Aug 9;34(8):840-850. [Abstract]
- bioRxiv. 2025 Sep 27.
Customer Validation & Images
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Activité biologique
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NMDA Receptor |
PEAQX tetrasodium hydrate (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pups obtained from deliveries of pregnant female Sprague-Dawley rats[2].
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Dosage:10, 20, 40 mg/kg
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Administration:Subcutaneous injection (s.c.)
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Result:Resulted in an 8-fold increase in caspase-3 activity in the striatum when administered at a dose of 20 mg/kg.
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Animal Model:11-week old C57BL/6 mice with cerebral ischemia[3].
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.); once daily; 4 days
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Result:Reduced protein expression levels in the CaMKIV-TORC1-p-CREB-BDNF pathway.
Chemical Information
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Appearance Solid
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Masse moléculaire 560.15
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Formule C17H15BrN3Na4O6P
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Color Off-white to yellow
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SMILES
BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]
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Synonyms
NVP-AAM077 tetrasodium hydrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Clin Invest
2019 Sep 3;129(9):3864-3876. PMID: 31424425 -
Brain Behav Immun
NR2B-CaMKII signaling in the dentate gyrus driven by astrocytic P2Y1Rs mediates the antidepressant effect of low-dose LPS. [Abstract]2026 Jul:135:106529. PMID: 41796645 -
Neurosci Bull
Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice. [Abstract]2025 Apr 28. PMID: 40293685 -
Cells
2023 Apr 22;12(9):1212. PMID: 37174612 -
Front Neurosci
GluN2A/ERK/CREB Signaling Pathway Involved in Electroacupuncture Regulating Hypothalamic-Pituitary-Adrenal Axis Hyperactivity. [Abstract]2021 Sep 30:15:703044. PMID: 34658758 -
Neuroscience
Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. [Abstract]2018 Nov 1:391:1-12. PMID: 30213765
PEAQX tetrasodium hydrate purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1:391:1-12. [Abstract]
PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.
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Am J Hypertens
Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Suppression of MEK/ERK/CREB Pathway. [Abstract]2021 Aug 9;34(8):840-850. PMID: 33856436 -
Solvant et solubilité
H2O : ≥ 25 mg/mL (44.63 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (178.52 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102. [Content Brief]
[2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91. [Content Brief]
[3]. Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.7852 mL | 8.9262 mL | 17.8524 mL | 44.6309 mL |
| 5 mM | 0.3570 mL | 1.7852 mL | 3.5705 mL | 8.9262 mL | |
| 10 mM | 0.1785 mL | 0.8926 mL | 1.7852 mL | 4.4631 mL | |
| 15 mM | 0.1190 mL | 0.5951 mL | 1.1902 mL | 2.9754 mL | |
| 20 mM | 0.0893 mL | 0.4463 mL | 0.8926 mL | 2.2315 mL | |
| 25 mM | 0.0714 mL | 0.3570 mL | 0.7141 mL | 1.7852 mL | |
| 30 mM | 0.0595 mL | 0.2975 mL | 0.5951 mL | 1.4877 mL | |
| 40 mM | 0.0446 mL | 0.2232 mL | 0.4463 mL | 1.1158 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PEAQX tetrasodium hydrate Related Classifications
HY-12294A Related Classifications
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