1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

PEAQX tetrasodium hydrate (Synonyms: NVP-AAM077 tetrasodium hydrate)

Cat. No.: HY-12294A Purity: 98.22%
Handling Instructions

PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).

For research use only. We do not sell to patients.

PEAQX tetrasodium hydrate Chemical Structure

PEAQX tetrasodium hydrate Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 177 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 768 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of PEAQX tetrasodium hydrate:

    PEAQX tetrasodium hydrate purchased from MCE. Usage Cited in: Neuroscience. 2018 Nov 1;391:1-12.

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM). IC50 value: 270 nM(hNMDA A1/A2) [1] Target: NR2A antagonist in vitro: PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over 1A/2B receptors (IC50=29,600 nM) [1]. in vivo: PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to PCP challenge on PN28-PN35 [2].

    Solvent & Solubility
    In Vitro: 

    H2O : 25.5 mg/mL (45.52 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7852 mL 8.9262 mL 17.8524 mL
    5 mM 0.3570 mL 1.7852 mL 3.5705 mL
    10 mM 0.1785 mL 0.8926 mL 1.7852 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    560.15

    Formula

    C₁₇H₁₅BrN₃Na₄O₆P

    SMILES

    [O-]P([O-])(C(N[[email protected]@H](C)C1=CC=C(Br)C=C1)C2=CC=CC3=C2N=C([O-])C([O-])=N3)=O.[H]O[H].[Na+].[Na+].[Na+].[Na+]

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 98.22%

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    Product Name:
    PEAQX tetrasodium hydrate
    Cat. No.:
    HY-12294A
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    PEAQX tetrasodium hydrate

    Cat. No.: HY-12294A