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  3. PEAQX tetrasodium hydrate

PEAQX tetrasodium hydrate  (Synonyms: NVP-AAM077 tetrasodium hydrate)

Cat. No.: HY-12294A Purity: ≥98.0%
COA Handling Instructions

PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively.

For research use only. We do not sell to patients.

PEAQX tetrasodium hydrate Chemical Structure

PEAQX tetrasodium hydrate Chemical Structure

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Solution
10 mM * 1 mL in Water USD 177 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 768 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of PEAQX tetrasodium hydrate:

Top Publications Citing Use of Products

    PEAQX tetrasodium hydrate purchased from MCE. Usage Cited in: Neuroscience. 2018 Nov 1;391:1-12.  [Abstract]

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively[1].

    IC50 & Target

    NMDA Receptor

     

    In Vitro

    PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration[2].
    PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F3, 73=4.99)[2].
    PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats[2].
    Dosage: 10, 20 or 40 mg/kg.
    Administration: S.C.
    Result: Showed a sensitized locomotor response to PCP challenge on PN28-35.
    Animal Model: Timed, day 14 pregnant female Sprague-Dawley rats[2].
    Dosage: 4 mg/kg.
    Administration: I.P.
    Result: Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.
    Animal Model: 11-week old C57BL/6 mice[3].
    Dosage: 10 mg/kg.
    Administration: IP.
    Result: Reversed the effect of PRE084 (F3,78 = 10.446, p<0.01).
    Molecular Weight

    560.15

    Formula

    C17H15BrN3Na4O6P

    SMILES

    BrC1=CC=C([[email protected]](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 25.5 mg/mL (45.52 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7852 mL 8.9262 mL 17.8524 mL
    5 mM 0.3570 mL 1.7852 mL 3.5705 mL
    10 mM 0.1785 mL 0.8926 mL 1.7852 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (178.52 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: ≥98.0%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    PEAQX tetrasodium hydrate
    Cat. No.:
    HY-12294A
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