ALDH1A3-IN-1
Based on 1 Customer Validation
ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 μM and a Ki of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 1695970-90-1
- Formula: C13H18BrNO
- Molecular Weight:284.19
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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ALDH1 |
ALDH1A3 0.63 μM (IC50) |
ALDH1A1 7.08 μM (IC50) |
ALDH3A1 8.00 μM (IC50) |
ALDH1A3 0.46 μM (Ki) |
ALDH1A3 26.92 μM (Km) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
61 μM
Compound: 14
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Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
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[PMID: 35212533] |
| LNCaP | IC50 |
25 μM
Compound: 14
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Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay
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[PMID: 35212533] |
| PC-3 | IC50 |
47 μM
Compound: 14
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Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
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[PMID: 35212533] |
ALDH1A3-IN-1 (Compound 14) (0-200 μM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1].
ALDH1A3-IN-1 (0-200 μM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, LNCaP, and DU145 cells
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Concentration:12.5-200 µM
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Incubation Time:96 h
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Result:Showed antiproliferative activity with IC50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells.
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Cell Line:Primary cells cultured at early passage from human prostate tissue biopsies
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Concentration:50 and 200 μM
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Incubation Time:72 h
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Result:Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.
Chemical Information
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CAS No. 1695970-90-1
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Appearance Liquid (Density: 1.284±0.06 g/cm3)
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Molecular Weight 284.19
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Formula C13H18BrNO
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Color Light yellow to yellow
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SMILES
O=CC1=CC(Br)=C(C=C1)N(CCC)CCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (351.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5188 mL | 17.5939 mL | 35.1877 mL | 87.9693 mL |
| 5 mM | 0.7038 mL | 3.5188 mL | 7.0375 mL | 17.5939 mL | |
| 10 mM | 0.3519 mL | 1.7594 mL | 3.5188 mL | 8.7969 mL | |
| 15 mM | 0.2346 mL | 1.1729 mL | 2.3458 mL | 5.8646 mL | |
| 20 mM | 0.1759 mL | 0.8797 mL | 1.7594 mL | 4.3985 mL | |
| 25 mM | 0.1408 mL | 0.7038 mL | 1.4075 mL | 3.5188 mL | |
| 30 mM | 0.1173 mL | 0.5865 mL | 1.1729 mL | 2.9323 mL | |
| 40 mM | 0.0880 mL | 0.4398 mL | 0.8797 mL | 2.1992 mL | |
| 50 mM | 0.0704 mL | 0.3519 mL | 0.7038 mL | 1.7594 mL | |
| 60 mM | 0.0586 mL | 0.2932 mL | 0.5865 mL | 1.4662 mL | |
| 80 mM | 0.0440 mL | 0.2199 mL | 0.4398 mL | 1.0996 mL | |
| 100 mM | 0.0352 mL | 0.1759 mL | 0.3519 mL | 0.8797 mL |
ALDH1A3-IN-1 Related Classifications
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