2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. ALDH1A3-IN-1

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer.

For research use only. We do not sell to patients.

ALDH1A3-IN-1 Chemical Structure

ALDH1A3-IN-1 Chemical Structure

CAS No. : 1695970-90-1

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Based on 1 publication(s) in Google Scholar

ALDH1A3-IN-1 Related Antibodies

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Description

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1].

IC50 & Target

ALDH1

 

ALDH1A3

0.63 μM (IC50)

ALDH1A1

7.08 μM (IC50)

ALDH3A1

8.00 μM (IC50)

ALDH1A3

0.46 μM (Ki)

ALDH1A3

26.92 μM (Km)

In Vitro

ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1].
ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALDH1A3-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: PC3, LNCaP, and DU145 cells
Concentration: 12.5-200 µM
Incubation Time: 96 h
Result: Showed antiproliferative activity with IC50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells.

Cell Viability Assay[1]

Cell Line: Primary cells cultured at early passage from human prostate tissue biopsies
Concentration: 50 and 200 μM
Incubation Time: 72 h
Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.
Molecular Weight

284.19

Formula

C13H18BrNO
CAS No.
Appearance

Liquid

Color

Light yellow to yellow

SMILES

O=CC1=CC(Br)=C(C=C1)N(CCC)CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (351.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5188 mL 17.5939 mL 35.1877 mL
5 mM 0.7038 mL 3.5188 mL 7.0375 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5188 mL 17.5939 mL 35.1877 mL 87.9693 mL
5 mM 0.7038 mL 3.5188 mL 7.0375 mL 17.5939 mL
10 mM 0.3519 mL 1.7594 mL 3.5188 mL 8.7969 mL
15 mM 0.2346 mL 1.1729 mL 2.3458 mL 5.8646 mL
20 mM 0.1759 mL 0.8797 mL 1.7594 mL 4.3985 mL
25 mM 0.1408 mL 0.7038 mL 1.4075 mL 3.5188 mL
30 mM 0.1173 mL 0.5865 mL 1.1729 mL 2.9323 mL
40 mM 0.0880 mL 0.4398 mL 0.8797 mL 2.1992 mL
50 mM 0.0704 mL 0.3519 mL 0.7038 mL 1.7594 mL
60 mM 0.0586 mL 0.2932 mL 0.5865 mL 1.4662 mL
80 mM 0.0440 mL 0.2199 mL 0.4398 mL 1.0996 mL
100 mM 0.0352 mL 0.1759 mL 0.3519 mL 0.8797 mL
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ALDH1A3-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALDH1A3-IN-11695970-90-1Aldehyde Dehydrogenase (ALDH)PC3LNCaPDU145Inhibitorinhibitorinhibit

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