1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Herboxidiene

Herboxidiene  (Synonyms: GEX1A)

Cat. No.: HY-19828 Purity: ≥99.0%
COA Handling Instructions

Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome.

For research use only. We do not sell to patients.

Herboxidiene Chemical Structure

Herboxidiene Chemical Structure

CAS No. : 142861-00-5

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Based on 1 publication(s) in Google Scholar

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Description

Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome[1][2].

In Vitro

Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM[3].
Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (bearing SVT2 murine fibrosarcoma)[3]
Dosage: 1 mg/kg
Administration: I.p.; once
Result: Showed significant antitumor activity on day 4.
Molecular Weight

438.60

Formula

C25H42O6

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

C[C@H]([C@H]([C@H](O)C)OC)[C@@]1([H])O[C@]1(C)C[C@@H](/C=C/C=C(C)/[C@H]2O[C@@H](CC(O)=O)CC[C@@H]2C)C

Structure Classification
Initial Source

Streptomyces chromofuscus A7847

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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Herboxidiene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Herboxidiene
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HY-19828
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