1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Herboxidiene

Herboxidiene (Synonyms: GEX1A)

Cat. No.: HY-19828
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Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome.

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Herboxidiene Chemical Structure

Herboxidiene Chemical Structure

CAS No. : 142861-00-5

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Description

Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome[1][2].

In Vitro

Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM[3].
Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively[3].

In Vivo

Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity[3].

Animal Model: BALB/c mice (bearing SVT2 murine fibrosarcoma)[3]
Dosage: 1 mg/kg
Administration: I.p.; once
Result: Showed significant antitumor activity on day 4.
Molecular Weight

438.60

Formula

C₂₅H₄₂O₆

CAS No.

142861-00-5

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Keywords:

HerboxidieneGEX1ADNA/RNA Synthesisphytotoxicpolyketideherbicidalanti-cholesterolanti-tumorspliceosomecellcyclearrestweedSF3bInhibitorinhibitorinhibit

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