SAR1A Protein, Human (GST)

The SAR1A protein critically facilitates intracellular transport from the endoplasmic reticulum to the Golgi apparatus. Through SAR1A-GTP-dependent assembly, it organizes endoplasmic reticulum exit sites (ERES), forming a scaffold that defines these sites. SAR1A Protein, Human (GST) is the recombinant human-derived SAR1A protein, expressed by E. coli , with N-GST labeled tag. The total length of SAR1A Protein, Human (GST) is 198 a.a., with molecular weight of ~49.4 kDa.

SAR1A Protein plays a crucial role in intracellular transport, specifically in facilitating the movement of cargo from the endoplasmic reticulum to the Golgi apparatus. By engaging in SAR1A-GTP-dependent assembly, it actively contributes to the organization of endoplasmic reticulum exit sites (ERES) by forming a structured scaffold that defines these sites on the ER membrane. Additionally, SAR1A is essential for maintaining the localization of SEC16A at discrete locations on the ER membrane, possibly by preventing its dissociation. The intricate interplay between SAR1A and SEC16A highlights the significance of SAR1A in orchestrating the molecular machinery involved in the precise regulation of membrane trafficking. Moreover, SAR1A interacts with B3GAT1, further underscoring its involvement in molecular interactions critical for cellular transport processes.

Human

E. coli

N-GST

Q9NR31 (1M-198D)

56681  [NCBI]

MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID

Approximately 49.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.