Ionizable lipid-2

Cat. No.: HY-160439 Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

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Ionizable lipid-2 (compound 1) is an ionizable lipid used for nucleic acid delivery and construct lipid nanoparticles (LNPs).

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Ionizable lipid-2 Chemical Structure

CAS No. : 2763904-72-7

Size	Price	Stock	Quantity
25 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

Ionizable lipid-2 (compound 1) is an ionizable lipid used for nucleic acid delivery and construct lipid nanoparticles (LNPs)^[1].

Molecular Weight

826.32

Formula

C₅₀H₉₉NO₇

CAS No.

2763904-72-7

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC(CCCCCCCC)CCCCCC)OCCCCCCN(CCCCCCOC(OCC(CCCCCCCC)CCCCCC)=O)CCCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (121.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2102 mL	6.0509 mL	12.1018 mL
5 mM	0.2420 mL	1.2102 mL	2.4204 mL
10 mM	0.1210 mL	0.6051 mL	1.2102 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

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Data Sheet (262 KB) SDS (0 KB)

COA (239 KB) HNMR (280 KB) RP-HPLC (255 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Haomeng Wang, et al. Preparation of ionizable lipid compound for nucleic acid delivery and its LNP composition and vaccine. CN116514672A.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2102 mL	6.0509 mL	12.1018 mL	30.2546 mL
	5 mM	0.2420 mL	1.2102 mL	2.4204 mL	6.0509 mL
	10 mM	0.1210 mL	0.6051 mL	1.2102 mL	3.0255 mL
	15 mM	0.0807 mL	0.4034 mL	0.8068 mL	2.0170 mL
	20 mM	0.0605 mL	0.3025 mL	0.6051 mL	1.5127 mL
	25 mM	0.0484 mL	0.2420 mL	0.4841 mL	1.2102 mL
	30 mM	0.0403 mL	0.2017 mL	0.4034 mL	1.0085 mL
	40 mM	0.0303 mL	0.1513 mL	0.3025 mL	0.7564 mL
	50 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6051 mL
	60 mM	0.0202 mL	0.1008 mL	0.2017 mL	0.5042 mL
	80 mM	0.0151 mL	0.0756 mL	0.1513 mL	0.3782 mL
	100 mM	0.0121 mL	0.0605 mL	0.1210 mL	0.3025 mL