Ionizable lipid-2
Based on 1 Customer Validation
Ionizable lipid-2 is a cationic lipid for nucleic acid delivery, with the ability to form lipid nanoparticle mRNA vaccines that exhibit in vitro stability and immunostimulatory activity. Ionizable lipid-2 can be used in studies related to herpes zoster, mRNA vaccines and nucleic acid delivery.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.75%
- CAS No.: 2763904-72-7
- Formule: C50H99NO7
- Masse moléculaire:826.32
-
Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-153378
Lipid 15Ionizable Lipid -
HY-147332
TCL053Nucleic Acid Carrier -
HY-156630
Ionizable lipid-1Ionizable Lipid -
HY-153186
LNP Lipid-3Ionizable Lipid -
HY-160552
244cisLiposome -
HY-153377
Lipid 14Amino Lipid -
HY-160553
9322-O16BIonizable Cationic Lipid -
HY-W598178
93-O17OCationic Lipid -
HY-149156
Lipid C24Lipid -
HY-157252
CL4F8-6Cationic Lipid -
HY-159716
Lipid 50Ionizable Lipid
Activité biologique
Description
In Vitro
Ionizable lipid-2 (Compound 1) is formulated with DSPC, cholesterol, and other components into a lipid mixture solution, and VZV gE mRNA is encapsulated via microfluidic mixing. The resulting LNP-mRNA vaccine shows a higher encapsulation efficiency than cationic lipids III, IV, and V, and possesses suitable average particle size, PDI, and Zeta potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2763904-72-7
-
Appearance Viscous Liquid
-
Masse moléculaire 826.32
-
Formule C50H99NO7
-
Color Colorless to light yellow
-
SMILES
O=C(OCC(CCCCCCCC)CCCCCC)OCCCCCCN(CCCCCCOC(OCC(CCCCCCCC)CCCCCC)=O)CCCCO
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (121.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 100 mg/mL (121.02 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.2102 mL | 6.0509 mL | 12.1018 mL | 30.2546 mL |
| 5 mM | 0.2420 mL | 1.2102 mL | 2.4204 mL | 6.0509 mL | |
| 10 mM | 0.1210 mL | 0.6051 mL | 1.2102 mL | 3.0255 mL | |
| 15 mM | 0.0807 mL | 0.4034 mL | 0.8068 mL | 2.0170 mL | |
| 20 mM | 0.0605 mL | 0.3025 mL | 0.6051 mL | 1.5127 mL | |
| 25 mM | 0.0484 mL | 0.2420 mL | 0.4841 mL | 1.2102 mL | |
| 30 mM | 0.0403 mL | 0.2017 mL | 0.4034 mL | 1.0085 mL | |
| 40 mM | 0.0303 mL | 0.1513 mL | 0.3025 mL | 0.7564 mL | |
| 50 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6051 mL | |
| 60 mM | 0.0202 mL | 0.1008 mL | 0.2017 mL | 0.5042 mL | |
| 80 mM | 0.0151 mL | 0.0756 mL | 0.1513 mL | 0.3782 mL | |
| 100 mM | 0.0121 mL | 0.0605 mL | 0.1210 mL | 0.3025 mL |
Ionizable lipid-2 Related Classifications
HY-160439 Related Classifications
Powered by Bioz