Topics

Lipid Nanoparticles: Key Nucleic Acid Delivery Vectors

Cancer Immunotherapy Intercellular Communication & Diseases

Lipid nanoparticles (LNPs) are the most clinically advanced non-viral delivery systems for nucleic acid therapeutics and enable the in vivo delivery of mRNA, siRNA, and other genetic cargos. The field evolved from early cationic lipid formulations to ionizable lipid-based nanoparticles and gained major clinical importance through the success of RNA interference therapeutics and mRNA vaccines. A typical LNP formulation contains ionizable lipids, cholesterol, helper phospholipids, and polyethylene glycol (PEG)-lipids. These components protect nucleic acids from enzymatic degradation, improve circulation stability, and enhance cellular uptake. The rapid expansion of RNA therapeutics, gene editing technologies, and precision medicine has established LNPs as a central platform in drug delivery and translational life sciences research[1][2][3][4].
The mechanism of LNP-mediated nucleic acid delivery involves nanoparticle assembly, endocytosis, endosomal trafficking, and cytoplasmic cargo release. Ionizable lipids remain largely neutral at physiological pH, reducing systemic toxicity, but become protonated in acidic endosomes, where they interact with anionic membrane lipids and promote membrane destabilization, fusion, and cargo release. Endosomal escape is widely recognized as the principal barrier limiting intracellular delivery efficiency and therefore represents a major focus of formulation engineering. Lipid composition influences encapsulation efficiency, transfection performance, tissue distribution, pharmacokinetics, and innate immune activation. The interaction between LNP components and host immune pathways is a critical determinant of therapeutic efficacy and safety[1][5][6][7][8].
LNPs are now extensively applied in mRNA vaccines, RNA interference therapies, protein replacement approaches, CRISPR-based genome editing, and cancer immunotherapy. Clinical and preclinical studies demonstrate efficient RNA delivery and robust protein expression following LNP administration. Nevertheless, limited tissue-specific targeting, inefficient endosomal escape, immune responses associated with repeated dosing, and incomplete understanding of structure-function relationships remain significant challenges. Future development is focused on next-generation ionizable lipids, organ-selective delivery technologies, cell-specific targeting strategies, and artificial intelligence-assisted nanoparticle design to improve the clinical performance of nucleic acid medicines[1][2][5][7][9][10].

Articles

All
  • All
  • Scientific Reviews
  • EDM
  • Blog
Most Recent
  • Most Recent
  • Oldest

Products

All
  • All
  • Inhibitors & Agonists
  • Isotope-Labeled Compounds
  • Fluorescent Dye
  • Peptides
  • Antibodies
  • Screening Libraries
  • Kits
  • Inhibitory Antibodies
  • Reference Standards
  • GMP Small Molecules
  • Biochemical Assay Reagents
  • Natural Products
Cat. No. Product Name Information Application Publication
HY-112251 D-Lin-MC3-DMA
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
Liposome  
170
HY-N0322A Cholesterol (Water Soluble)
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells.
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
Liposome  
Atherosclerosis   Hypercholesterolemia  
95
HY-N0322 Cholesterol (from animal)
Cholesterol (from animal) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (from animal) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol (from animal) is also an endogenous estrogen-related receptor α (ERRα) agonist.
Endogenous Metabolite   Liposome   Bacterial   Estrogen Receptor/ERR  
Breast Cancer   Viral Infection   Bacterial Infection   Pancreatic Ductal Adenocarcinoma   Hepatitis B Virus Infection   Alzheimer's Disease   Sepsis   Atherosclerosis   Type 2 Diabetes   Obesity   Hypercholesterolemia  
95
HY-L015 PI3K/Akt/mTOR Compound Library
The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials. MCE owns a unique collection of 1,149 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

Signaling Pathway Targeting Libraries

90
HY-L031 Small Molecule Immuno-Oncology Compound Library
Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines. MCE Small Molecule Immuno-Oncology Compound Library offers 831 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Disease Focused Libraries

88
HY-L077 Anti-Pancreatic Cancer Compound Library
Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer. MCE offers a unique collection of 4,336 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

Disease Focused Libraries

85
HY-L075 Anti-Lung Cancer Compound Library
Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 3,061 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Disease Focused Libraries

84
HY-L039 Reprogramming Compound Library
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 3,231 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Signaling Pathway Targeting Libraries

83
HY-L079 Anti-Blood Cancer Compound Library
Blood cancers, also called hematologic cancers, occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection and produce new blood cells. Most blood cancers start in the bone marrow, which is where blood is produced. There are three main types of blood cancers: leukemia, lymphoma and myeloma, which afflict millions of children and adults every year, and are often deadly. Some common blood cancer treatments include stem cell transplantation, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. As we begin to understand the key signaling pathways and molecular drivers of malignant transformation in haematological disorders, new treatment strategies will continue to be developed. MCE offers a unique collection of 4,333 compounds with identified and potential anti-blood cancer activity. These compounds target blood cancer’s major targets and signaling pathways. MCE anti-blood cancer compound library is a useful tool for anti-blood cancer drugs screening and other related research.

Disease Focused Libraries

83
HY-L171 Anti-Hematopathy Compound Library
Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs. MCE designs a unique collection of 4,388 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

Disease Focused Libraries

83
HY-L213 Anti-Cancer Approved Drug Library
The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies. This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment. MCE has collected 265 small-molecule compounds with cancer indications, which are good tools for drug repurposing.
83
HY-L214 Liposome Library
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 227 liposome compounds, which is a good tool for drug delivery-related studies.
83
HY-L216 Polysaccharides Compound Library
Polysaccharides are long chains of carbohydrate molecules, consisting of multiple smaller monosaccharides. Polysaccharides are found mainly in natural sources such as plants, microorganisms, algae and animals. Polysaccharides have a large number of active functional groups, different chemical compositions and different molecular weight ranges, which determines their diversity in nature and structure. Also in the field of medical research, polysaccharides act as a class of functional compounds and thus play a role. For example, nanocarrier construction, immunomodulation and vaccine development, new strategies for antitumor therapy, tissue regeneration engineering applications and disease diagnosis. With the advancement of glycomics and synthetic biotechnology, human beings are moving from “knowing polysaccharides” to “designing polysaccharides”, which will provide innovative solutions for materials science, precision medicine and sustainable development. MCE offers 70 polysaccharides that can be used in biomedical studies.
83
HY-L219 Antimicrobial Peptides Library
Antimicrobial Peptides (AMPs), also known as antimicrobial peptides or antibiotic peptides, are a class of polypeptides encoded by specific genes in various biological cells and induced by external stimuli. They exhibit broad-spectrum bioactivity against bacteria, fungi, viruses, protozoa, and even tumor cells. AMPs serve as crucial effector molecules in the host's innate immune system.Due to their wide antimicrobial spectrum, low toxicity to normal cells of higher animals, high safety profile, low tendency to induce resistance, and additional benefits such as immune enhancement and antioxidant effects, antimicrobial peptides hold significant promise in new drug development. MCE offers 58 types of antimicrobial peptides, which can be applied in high-throughput screening for research in anti-infection therapies, immunotherapy, anticancer drug development, and agricultural disease control.
83
HY-L244 High-Efficiency Gene Editing Compound Library
In this era of rapid advancement in gene-editing technology, the CRISPR-Cas system, with its powerful programmability, is leading a transformation in life sciences research. It enables efficient and precise targeted modification of an organism's genome, providing a robust tool for studying gene function, treating genetic diseases, and improving crop varieties. However, bottlenecks such as insufficient editing efficiency, low homologous directed repair efficiency, and potential off-target risks remain major challenges in achieving precise genetic modifications and developing gene therapies. To overcome these limitations, the MCE High-Efficiency Gene Editing Compound Library systematically includes 761 small molecules that are known or have the potential to enhance gene-editing efficiency. These compounds work by targeting and modulating the DNA damage repair network, mechanistically inhibiting non-homologous end joining, promoting homologous directed repair, or regulating chromatin states and cellular responses, thereby significantly optimizing editing outcomes. This library is suitable for developing "CRISPR-small molecule" combination therapy strategies, improving gene-editing efficiency, and providing a powerful tool for in-depth research into the mechanisms of DNA damage repair in gene editing.

Signaling Pathway Targeting Libraries

83
HY-L248 RNA Binding Bioactive Compound Library
The RNA-targeted bioactive compound library is a high-quality collection of small molecules specifically designed and curated to target RNA structures and functions. It is widely applied in cutting-edge drug discovery and life science research. Unlike traditional strategies that focus on protein targets, RNA-targeted compounds can directly modulate various functional RNA molecules by influencing their splicing, translation, stability, or structural conformation, thereby enabling precise intervention in key biological processes. In the field of drug development, these compounds provide a novel approach to addressing previously “undruggable” targets and have demonstrated significant potential in areas such as oncology, antiviral therapies, and neurodegenerative diseases. For example, by targeting disease-associated RNA structural domains or regulating the aberrant expression of non-coding RNAs, these compounds can effectively inhibit disease progression or restore normal cellular function. In mechanistic studies, RNA-targeted compounds serve as valuable chemical biology tools to elucidate the roles of RNA in gene expression regulation, cellular signaling pathways, and disease development. The MCE RNA-targeted bioactive compound library contains 858 compounds, sourced from databases such as TargetRX Atlas and R-BIND. The library features excellent structural diversity and biological activity, making it suitable for high-throughput screening (HTS), target validation, phenotypic screening, and lead compound discovery. It represents a valuable resource for RNA-related research and innovative drug development.

Signaling Pathway Targeting Libraries

83
HY-L251 Ionizable Lipid Compound Library
Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application. To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 93 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Structure Classified Libraries

83
HY-L260 KRAS Targeted Compound Library
KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog) is one of the most important oncogenic driver genes in oncology, with high mutation frequencies in pancreatic cancer, non‑small cell lung cancer, and colorectal cancer. For a long time, KRAS was considered "undruggable" due to the lack of suitable small‑molecule binding pockets on its protein surface. In recent years, with the discovery of the switch‑II pocket and the successful approval of KRAS G12C inhibitors, KRAS‑targeted research has achieved groundbreaking progress, which has also spurred a wave of development targeting non‑G12C mutants such as G12D and G12V, as well as upstream and downstream regulatory factors including SOS1 and SHP2. MCE KRAS Targeted Compound Library contains 82 small‑molecule compounds targeting the KRAS, serving as high‑quality research tools for mechanistic studies of KRAS‑mutant tumors, combination therapy development, resistance mechanism exploration, and high‑throughput drug screening, thereby providing robust support for KRAS‑targeted drug discovery.

Signaling Pathway Targeting Libraries

83
HY-L948 PD-1/PD-L1 Lead-like Library
PD-1/PD-L1 are key immune checkpoint targets that suppress T-cell-mediated anti-tumor immunity, representing a major focus in cancer immunotherapy. While antibody drugs dominate the clinic, they are limited by administration challenges and immune-related side effects. Small-molecule PD-1/PD-L1 inhibitors, with oral availability, good tissue penetration and low cost, have emerged as a promising next-generation strategy. A PD-1/PD-L1 lead-like library was built via a five-step virtual screening process. After collecting 8,947 inhibitors from BindingDB and PubChem and filtering by activity and duplicates, AI similarity screening was performed using GeminiMol. Key pharmacophores were extracted from the PPI interface of co-crystal structures, and molecular was screened via a pharmacophore model, effectively enhancing target activity. Containing 10,000 structurally diverse and drug-like molecules well-matched to the PD-L1 pocket, the library supports virtual docking, high-throughput screening and hit discovery, enabling efficient and rapid development of small-molecule immunotherapies.

Focused and target libraries

83
HY-N1446A Glycerol Monoleate
Glycerol Monoleate is a non-toxic, biodegradable, biocompatible, lipophilic glycerol fatty acid ester. Glycerol Monoleate exhibits hemolytic properties. Glycerol Monoleate is combined with bile salts for use as an emulsifier and absorption enhancer. Glycerol Monoleate can be applied in drug delivery systems and in vitro siRNA delivery.
Endogenous Metabolite  
75
HY-134541 SM-102
SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
Liposome  
Infection  
54
HY-138170 ALC-0315
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
Liposome   SARS-CoV  
SARS-CoV-2 Infection  
46
HY-P9902 Pembrolizumab
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

Species: Human

PD-1/PD-L1  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
37
HY-112764 mPEG2000-DMG
mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
Liposome  
Metabolic or Endocrine Disease  
27
HY-W040193 DSPC
DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Liposome  
22
HY-112754A DOTAP chloride
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
Liposome  
20
HY-142979 DSPE-PEG 2000
DSPE-PEG 2000 is a PEG polymer containing DSPE. DSPE-PEG 2000 can be used to form micelles as nanoparticles for drug delivery.
Liposome  
17
HY-112005 DOPE
DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.
Liposome   Endogenous Metabolite   ACSL Family   Amino acid Transporter   Ferroptosis   Glutathione Peroxidase  
Cancer   Inflammation or Immune System Disease  
14
HY-107780A Cyclic-di-GMP sodium
Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research.

Source: bacterial species

STING   Endogenous Metabolite  
9
HY-107780 Cyclic-di-GMP
Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research.

Source: bacterial species

STING   Endogenous Metabolite  
9
HY-107780B Cyclic-di-GMP diammonium
Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
STING   Endogenous Metabolite  
Cancer   Bacterial Infection  
9
HY-110382 Cyclic-di-GMP disodium
Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
STING   Endogenous Metabolite  
9
HY-P9921 Trastuzumab emtansine
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer.
Antibody-Drug Conjugates (ADCs)   EGFR  
HER-2 Positive Breast Cancer   Metastatic Breast Cancer  
8
HY-P99032 Monalizumab
Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC).

Species: Human

Checkpoint Kinase (Chk)   IFNAR  
Breast Cancer   Non-Small Cell Lung Cancer  
7
HY-134781 CKK-E12
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
Liposome  
6
HY-Y0850O Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed)
Polyvinyl alcohol (PVA; Poly (Ethenol)) (Mw 31000-50000, 87-89% hydrolyzed) is a polymer with emulsifying and stabilizing properties, with a degree of hydrolysis of 87-89%. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) mainly acts as a stabilizer in the preparation of nanomedicines; it not only maintains the structural integrity of PEGylated PLGA nanoparticles during double emulsion synthesis, but also facilitates the preparation of chitosan/matrine-PLGA nanoparticle aqueous solutions and lipid-polymer nanoparticles. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) can be widely used in research related to fields such as breast cancer.
Environmental Pollutants   Biochemical Assay Reagents  
Breast Cancer  
3
HY-N4087 Platycodin D2
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology.
Mitophagy   Autophagy   Ferroptosis   Interleukin Related   IFNAR   Reactive Oxygen Species (ROS)  
Cancer   Inflammation or Immune System Disease  
3
HY-141601 Telisotuzumab vedotin
Telisotuzumab vedotin (ABBV-399) (Teliso-V) is an anti-c-Met antibody-drug conjugate. Telisotuzumab vedotin consists of an anti-c-Met monoclonal antibody Telisotuzumab (ABT-700) (HY-P99391) and Monomethyl Auristatin E (HY-15162). Telisotuzumab vedotin exerts antitumor activity with acceptable toxicity in vivo. Telisotuzumab vedotin can be used for non-small cell lung cancer (NSCLC) research.
Antibody-Drug Conjugates (ADCs)   c-Met/HGFR   Microtubule/Tubulin  
Non-Small Cell Lung Cancer  
3
HY-145793 FTT5
FTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo.
Liposome  
Blood or Cardio-cerebrovascular Disease  
2
HY-W073524 DFAME
DFAME is a red fluorophore (Ex = 508 nm, Em = 641 nm). DFAME binds to Beetroot and Corn (dimeric fluorescent RNA aptamers) to form Beetroot-DFAME (Kd = 460 nM) and Corn-DFAME (Kd = 3600 nM). Beetroot-DFAME and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research.
Fluorescent Dye  
2
HY-137500 NT1-O14B
NT1-O14B is a tryptamine-derived lipidoid. NT1-O14B incorporates NT-lipidoid into BBB-impermeable lipid nanoparticles (LNPs), enabling the LNPs to cross the BBB. NT1-O14B enhances brain delivery via intravenous injection. NT1-O14B can be used in ischemic stroke research.
Liposome   Biochemical Assay Reagents  
Ischemic Stroke  
2
HY-W590532 306-O12B
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA.
Liposome  
2
HY-119109 Laminaran
Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy.

Source: Eisenia Bicyclis

Environmental Pollutants   C-type Lectin-like Receptors (CTLRs)   Endogenous Metabolite  
Colorectal Cancer  
2
HY-156630A Ionizable lipid-1 hydrochloride
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.
Liposome  
1
HY-P10055 PSMA targeting peptide
PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells. PSMA-1 is selected and polyarginine sequences R6 or R9 were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1，to track PSMA binding on PCa cells.
PSMA  
Cancer  
1
HY-N15956 DMG-PEG(2k)-DBCO
DMG-PEG(2k)-DBCO is a Clickable PEG lipid containing a DBCO group. DSPE-PEG8-DBCO can be used to prepare lipid nanoparticles for drug delivery.
Liposome  
1
HY-P10055A PSMA targeting peptide TFA
PSMA targeting peptide TFA (PSMA-1 TFA) is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells.
PSMA  
Cancer  
1
HY-153373 4A3-Cit
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
Liposome  
1
HY-W591461 DSPE-PEG-COOH, MW 2000
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
Liposome  
Cancer  
1
HY-150115 Lipid 10
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
Liposome  
1
HY-156630 Ionizable lipid-1
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.
Liposome  
1
HY-N5084 Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a TRPV1 antagonist and HDAC7 inhibitor. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside blocks TRPV1-mediated calcium influx, suppresses phosphorylation of p65, IκBα, p38, JNK, and ERK1/2, inhibiting NF-κB and MAPK signaling cascades. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside reduces production and gene expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside exhibits potent analgesic activity, elevates thermal pain threshold and mechanical pain threshold in murine models. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside restores CD8+ T cell infiltration into bladder cancer tumors and improves bladder cancer immunotherapy efficacy. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can be used for the researches of painand bladder cancer.
TRP Channel   HDAC   p38 MAPK   JNK   ERK   NF-κB   TNF Receptor   Interleukin Related  
Inflammation or Immune System Disease   Bladder Cancer   Pain  
1
HY-148855 OF-C4-Deg-Lin
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA.
Liposome  
1
HY-139305 CL4H6
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response.
Liposome  
Cancer  
1
HY-153229 Firefly luciferase mRNA-LNP
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency.
mRNA   Biochemical Assay Reagents  
1
HY-P10128 GE11
GE11 is a active peptide and combines with colloidal drug delivery systems as smart carriers for antitumor drugs and can be used for cancer study.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
1
HY-113217 Cholesteryl oleate
Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing.
Liposome   Endogenous Metabolite  
Metabolic or Endocrine Disease   Prostate Cancer  
1
HY-151507 Tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery.
Liposome  
1
HY-112760 18:0 mPEG2000 PE sodium
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery.
Liposome  
1
HY-W583868 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.
Liposome  
1
HY-W440835 DSPE-PEG2000-DBCO
DSPE-PEG2000-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 1000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG2000-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG2000-DBCO can be used in studies related to atherosclerosis.
Liposome  
Atherosclerosis and Inflammation  
1
HY-P99901 Sibeprenlimab
Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN).

Species: Human

SARS-CoV  
Cancer   Inflammation or Immune System Disease  
1
HY-K2023 In vivo OptiLNP RNA Transfection Reagent (Local Effect)

MCE In vivo OptiLNP RNA Transfection Reagent (Local Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions locally.

Cell Biology Cell Culture Cell Transfection

1
HY-159862 IM21.7c
IM21.7c is a cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
Infection  
/
HY-177614 ALN-3133 sodium
ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.
VEGFR  
Cancer  
/
HY-W440681 C13-112-tri-tail
C13-112-tri-tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tri-tail can be formulated into a lipid nanoparticle (LNP).
Liposome  
/
HY-N15786 DSPE-RGD Lipid sodium
DSPE-RGD Lipid sodium is a lipid containing DSPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
/
HY-172499 DSPE-PEG1000-SP94
DSPE-PEG1000-Mal-CLPLIPTHIISFS is a PEG compound composed of DSPE and the liver cancer targeting peptide SP94 (HY-P11050A) (sequence SFSIIHTPILPL). SP94 exhibits specific binding to hepatocellular carcinoma (HCC) cells. DSPE-PEG1000-Mal-CLPLIPTHIISFS can be used to prepare lipid nanoparticles to form liver cancer-targeting nanocarriers.
Liposome  
Cancer  
/
HY-176027 CP-LC-1422
CP-LC-1422 is a homocysteine-derived ionizable amino lipid with high RNA delivery capability and can mediate high-level protein expression in vivo. CP-LC-1422 exhibits significant spleen targeting via intravenous injection in a lipid nanoparticle (LNP) formulation with no significant toxicity observed.
Liposome  
/
HY-171896 A28-C6B2
A28-C6B2 is an ionizable cationic lipid with a pKa of 6.43, and can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. A28-C6B2 can be studied in research for enhancing the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells.
Liposome  
Cancer   Inflammation or Immune System Disease  
/
HY-W440684 C13-113-tetra-tail
C13-113-tetra tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tetra tail can be formulated into a lipid nanoparticle (LNP).
Liposome  
/
HY-W591449 DOPE-PEG2000-Azide
DOPE-PEG2000-Azide is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body.
Liposome  
Cancer  
/
HY-179861 BODIPY 505/515 11:0 Lyso PC
BODIPY 505/515 11:0 Lyso PC is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Lipid Metabolism  
/
HY-P10649 CPP12
CPP12 is a small, amphipathic, cyclic cell-penetrating peptide (CPP). CPP12 binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and then efficiently escapes from endosomes. CPP12 can be used for the intracellular delivery of drugs and chemical probes.
Others  
Cancer  
/
HY-171927 Lipid 12T-O14
Lipid 12T-O14 is a lipid nanoparticle. 12T-O14 facilitates local mRNA vaccine and systemic mRNA agent delivery.
Liposome  
Cancer   Inflammation or Immune System Disease  
/
HY-D3419 Neuro-DiO 4-chlorobenzenesulfonate
Neuro-DiO 4-chlorobenzenesulfonate is a hydrophobic C18 alkyl chain carbocyanine dye with green fluorescence, commonly used as a vascular marker, cell internalizer and deposition agent. Neuro-DiO 4-chlorobenzenesulfonate inserts its alkyl chain into the endothelial plasma membrane via liposome-mediated perfusion to achieve vascular labeling. Neuro-DiO chlorobenzenesulfonate can also stain the cell membrane and cytoplasm of cancer cells to assist in confocal microscopy observations. Neuro-DiO chlorobenzenesulfonate can be released from nanosponges and accumulate on the surface of mouse retina, then internalize into retinal ganglion cells, which is applicable to researches related to glaucoma and other diseases. It should be noted that during liposome-mediated vascular staining in mice, Neuro-DiO 4-chlorobenzenesulfonate may cause leakage of airway lavage fluid.
Fluorescent Dye  
Glaucoma  
/
HY-171905 N-Sterol
N-Sterol is a sterol lipid that has been used to generate lipid nanoparticles (LNPs) for delivery of mRNA in vitro and in vivo. N-Sterol LNPs are taken up in J774A.1 macrophages in a lipid composition-dependent manner via clathrin caveolae, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis at different frequencies.
Liposome  
/
HY-N16291 DSG-pSar25-Maleimide
DSG-pSar25-Maleimide is a lipid that is composed of a DSG unit conjugated to a pSar25 polymer. DSG-pSar25-Maleimide can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-W590547 (6-(4-Hydroxybutylamino)hexyl)carbamic undecyl
(6-(4-Hydroxybutylamino)hexyl)carbamic undecyl is a lipid with a terminal hydroxyl group, which is used to construct or modify lipid nanoparticles (LNP). (6-(4-Hydroxybutylamino)hexyl)carbamic undecyl can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-N16312 Chol-mPEG3400
Chol-mPEG3400 is a PEG lipid containing cholesterol and can be used to prepare lipid nanoparticles for drug delivery.
Liposome  
/
HY-172332 H1L1A1B3
H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA). H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315 (HY-138170). H1L1A1B3 can activate the NF-κB/IRF immune pathways.
Liposome   NF-κB  
Inflammation or Immune System Disease   Lung Cancer  
/
HY-W440683 C13-112-tetra-tail
C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).
Liposome  
/
HY-141520G ART558 (GMP)
ART558 (GMP) is ART558 (HY-141520) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ART558 is a potent, selective and allosteric DNA polymerase theta (Polθ) inhibitor (IC50=7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer, such as breast cancer.
DNA/RNA Synthesis  
Cancer  
/
HY-46759A Genevant CL1 monohydrochloride
Genevant CL1 monohydrochloride is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 monohydrochloride is a component of lipid nanoparticle delivery systems for mRNA vaccines.
Liposome  
Infection  
/
HY-W440835A DSPE-PEG400-DBCO
DSPE-PEG400-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 400 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Biochemical Assay Reagents  
Atherosclerosis and Inflammation  
/
HY-N16233 Chol-PEG2000 fluorescein
Chol-PEG2000 fluorescein is a fluorescent lipid that consists of a cholesterol-PEG2000 unit conjugated to fluorescein. Chol-PEG2000 fluorescein can be used to prepare lipid nanoparticles for drug delivery research (Ex/Em = 480/520 nm).
Fluorescent Dye  
/
HY-172328 O12-D3-I3
O12-D3-I3 is an ionizable cationic lipid. O12-D3-I3 can be used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo. LNPs containing O12-D3-I3 enhances LNP endosomal escape for ferroptosis RNAi therapy of cancer.
Liposome  
Cancer  
/
HY-W040193S5 DSPC-d9
DSPC-d9 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-50698G BI 2536 (GMP)
BI 2536 (GMP) is BI 2536 (HY-50698) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-β) gene transcription.
Polo-like Kinase (PLK)   Epigenetic Reader Domain   Apoptosis  
/
HY-168370 YHS-12
YHS-12 is an ionizable cationic lipid, which can be used to synthesize lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA.
Liposome  
Cancer   Inflammation or Immune System Disease  
/
HY-171114 DMT7
DMT7 is an ionizable cationic lipid (pKa = 6.5) that can be used to generate lipid nanoparticles (LNPs) for delivery of mRNA and anticancer drugs in the body.
Liposome  
/
HY-W583868S 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62 (1,2-POPE-d62) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.
Isotope-Labeled Compounds  
/
HY-P12013 PEG12KL4
PEG12KL4 is a PEG-modified amphipathic cell-penetrating peptide. PEG12KL4 promotes the transfection and delivery of mRNA into lung cells, maintains mRNA stability, and forms mRNA complexes that retain integrity and translatability. PEG12KL4 endows lipid nanoparticles (LNPs) with anti-nebulization properties, enhances transfection efficiency in artificial mucus when used in combination with LNPs, and enables the formation of dry powder formulations with low toxicity and mild inflammatory responses. PEG12KL4 can be used in studies related to drug delivery for pulmonary diseases (cystic fibrosis, chronic obstructive pulmonary disease).
Biochemical Assay Reagents  
Pulmonary Disease  
/
HY-177613A ALN-12115 sodium
ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
Kinesin  
Cancer  
/
HY-P11614 LCA-H10
LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer.
Liposome  
Prostate Cancer  
/
HY-174947 DPPE-PEG2-mal
DPPE-PEG2-mal is an amphiphilic phospholipid-modified polymer that can be used to prepare lipid nanoparticles or liposomes for targeted drug delivery applications.
Liposome  
/
HY-179862 BODIPY 505/515 11:0 Lyso PE
BODIPY 505/515 11:0 Lyso PE is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-P4087 Cys(Npys)-(Arg)9
Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection.
HIV  
HIV Infection   Squamous Cell Carcinoma  
/
HY-159853 C14-A1
C14-A1 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
Inflammation or Immune System Disease  
/
HY-171954 9C-SCC-10
9C-SCC-10 is a crown-like biodegradable ionizable lipid. 9C-SCC-10 an be used to prepare lipid nanoparticles for delivering mRNA and targeting lung tissue. 9C-SCC-10 can be used for early detection and diagnosis of lung cancer.
Liposome  
Cancer  
/
HY-159856 16:0 Cardiolipin
16:0 Cardiolipin (Diphosphatidylglycerol (16:0)) is a phospholipid derived from Palmitic acid (16:0) that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
/
HY-171019 Lipid 119-23
Lipid 119-23 is an ionizable cationic lipid which can be utilized in the formation of lipid nanoparticles and the delivery of mRNA. Lipid 119-23 exhibits an enhanced capability to express functional mCre in several categories of immune cells, spanning the liver, spleen and lung.
Liposome  
/
HY-W440891 DSPE-PEG1000-OH
DSPE-PEG1000-OH is a hydroxyl terminated phospholipid PEG polymer. The hydrophobic tails allow for the encapsulation and congregation of other hydrophobic drugs. The polymer can be used to prepare liposomes or lipid nanoparticles. Hydroxyl terminal can further derivatize the compound.
Biochemical Assay Reagents  
/
HY-N15973 DSPE PEG2k-OH ammonium
DSPE PEG2k-OH ammonium is a hydroxyl-terminated PEGylated phospholipid. The hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and the hydroxyl terminus is suitable for further reactions. DSPE PEG2k-OH ammonium can be used to prepare liposomes or lipid nanoparticles.
Liposome  
/
HY-N15852 APL-719
APL-719 is a cationic lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-N15951 C16 Ceramide-suc-PEG2K-maleimide
C16 Ceramide-suc-PEG2K-maleimide is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Liposome  
/
HY-173379 C10 DG PEG 2000
C10 DG PEG 2000 (1,2-didecanoyl-rac-glycero-3-methoxypolyethylene glycol-2000) is a PEG lipid consisting of a glycerol backbone with two C10 acyl chains and PEG 2000 units. C10 DG PEG 2000 can be used for lipid nanoparticle and liposome formation.
Biochemical Assay Reagents  
Cancer  
/
HY-N0390G L-Glutamine (GMP)
L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
mTOR   NF-κB   STAT   HIF/HIF Prolyl-Hydroxylase  
Inflammation or Immune System Disease   Ischemic Stroke   Osteoporosis   Osteoarthritis  
/
HY-D2100A Cy5-DSPE chloride ammonium
Cy5-DSPE chloride ammonium is a far-infrared fluorescent phospholipid (λex/λem = 600/665 nm). Cy5-DSPE chloride ammonium is used to label liposomes, membranes and lipid nanoparticles, and can be applied to tracking and imaging studies of liposomes.
Fluorescent Dye  
/
HY-W591476A m-PEG3400-thiol
m-PEG3400-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
Biochemical Assay Reagents  
/
HY-W440835B DSPE-PEG600-DBCO
DSPE-PEG600-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 600 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Biochemical Assay Reagents  
Atherosclerosis and Inflammation  
/
HY-P10560 M918
M918 is a cell-penetrating peptide. M918 is internalized by cells through endocytosis and can effectively penetrate a variety of cells in a non-toxic manner. M918 can be used in gene therapy and drug delivery system research.
Biochemical Assay Reagents  
/
HY-P10514 Transportan 10
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research.
Small Interfering RNA (siRNA)  
/
HY-D1005I Poloxamer L61
Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production.
Biochemical Assay Reagents  
/
HY-113217S1 Cholesteryl oleate-d7-1
Cholesteryl oleate-d7-1 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-185658 3'-BPANeuGc
3'-BPANeuGc is a high-affinity selective Siglec-G ligand. Lipid nanoparticles surface-modified with antigens and 3'-BPANeuGc inhibit BCR signal transduction. 3'-BPANeuGc is applicable to antigen-specific tolerance research.
Bcr-Abl   Liposome  
Inflammation or Immune System Disease  
/
HY-N15988 DOCPe
DOCPe is a choline-phosphate lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-P5307A Peptide A5K acetate
Peptide A5K (INF7-A5K-TAT) acetate is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K acetate can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K acetate enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy.
Biochemical Assay Reagents  
/
HY-W591332 mPEG2000-DMPE
mPEG2000-DMPE is a pegylated lipid with a methyl group at the opposite end of the PEG chain, and can be used for the preparation of lipid nanoparticles or liposomes for targeted drug delivery applications. mPEG2000-DMPE is applicable for siRNA-related application studies targeting macrophages and dendritic cells.
Liposome  
Cancer  
/
HY-P10520 RWmix
RWmix is ??a synthetic cell-penetrating peptide. The secondary amphiphilic nature of RWmix promotes cellular uptake, mainly due to the alternating arrangement of arginine and tryptophan. The presence of tryptophan enhances the anchoring of the peptide to the cell membrane, thereby improving its ability to penetrate the cell membrane. RWmix can be used for gene therapy and siRNA delivery research.
Others  
/
HY-P11113 PFVYLI
PFVYLI is a hydrophobic penetrating peptide that can be used to modify doxorubicin-loaded stealth persistent liposomes (PFV-ssls-dox) for breast cancer research.
Others  
/
HY-W665456 Fmoc-PNA-U-OH
Fmoc‑PNA‑U‑OH is a peptide nucleic acid monomer that can be used for the synthesis of peptide nucleic acids (PNAs). Fmoc‑PNA‑U‑OH exhibits specific binding to adenine, resistance to enzymatic degradation, and strong hybridization properties. Fmoc‑PNA‑U‑OH can be applied in research fields such as gene diagnosis, molecular biology, and antisense therapy.
Drug Intermediate  
/
HY-133952 7-Oxotridecanedioic acid
7-Oxotridecanedioic acid is a biodegradable cationic lipid intermediate compound for lipid nanoparticles formation. 7-Oxotridecanedioic acid can be incorporated into a lipid particle for delivering active agents.
Liposome  
Cancer  
/
HY-172334 2N12B
2N12B is a bioreducible ionizable lipid containing disulfide bonds. 2N12B can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. Lipid nanoparticles containing 2N12B can deliver siRNA to inhibit retinal neovascularization.
Liposome  
Metabolic or Endocrine Disease  
/
HY-169480 Lipid C2
Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3+CD8+ central and CD3+CD8+ effector memory T cells and decrease the percentage of CD3+ T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model.
Liposome  
Cancer   Infection  
/
HY-172535 Lipid OA2 dihydrochloride
Lipid OA2 dihydrochloride is an ionizable cationic lipid that can be used to prepare single-component lipid nanoparticles for siRNA delivery. Lipid OA2 dihydrochloride can effectively deliver SOCS1-siRNA to dendritic cells, silence the SOCS1 gene, and enhance their antigen-presenting ability and pro-inflammatory factor secretion capacity.
Lipase  
Cancer   Inflammation or Immune System Disease  
/
HY-167819 D-Erythro-sphingosyl phosphoinositol
D-Erythro-sphingosyl phosphoinositol is a lipid nanoparticle covalently linked to an antibody with potential activity in targeted compound delivery. D-Erythro-sphingosyl phosphoinositol can enhance the accumulation of compounds in specific cell types. D-Erythro-sphingosyl phosphoinositol may be used as a ligand to enhance the effect of antibodies in immunosuppression. D-Erythro-sphingosyl phosphoinositol can also be used to study the mechanisms related to cell signaling and lipid metabolism.
Biochemical Assay Reagents  
/
HY-W040193S6 DSPC-d13
DSPC-d13 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d13) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-W040193S2 DSPC-d79
DSPC-d79 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-171898 Lipid I97
Lipid I97 is an ionizable lipid derived from vitamin B5 (pKa = 6.23). Lipid I97 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. Lipid I97 can be studied in research for enhancing mRNA transfection efficiency and long-term stability as well as formulation of mRNA vaccines.
Liposome  
Cancer   Inflammation or Immune System Disease  
/
HY-173376 C12 DG PEG (MW 2000)
C12 DG PEG (1,2-Didodecanoyl-rac-glycero-3-methoxypolyethylene glycol) (MW 2000) is a PEG lipid that can be used in lipid nanoparticle and liposome formation. C12 DG PEG (MW 2000) is promising for research of cancers.
Liposome  
Cancer  
/
HY-160578 Glucosamine Cholesterol
Glucosamine Cholesterol (N-Cholesteryl succinyl glucosamine) is a glucosamine-based lipid conjugate, and can be used in the formation of lipid nanoparticles (LNPs).
Liposome  
/
HY-D2100 Cy5-DSPE
Cy5-DSPE is a far-infrared fluorescent phospholipid (λex/λem = 600/665 nm). Cy5-DSPE is used to label liposomes, membranes and lipid nanoparticles, and can be applied to tracking and imaging studies of liposomes.
Fluorescent Dye  
/
HY-169478 Lipid N2-3L
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that can be used to generate supramolecular lipid nanoparticles (SMLNPs) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod (HY-13740) with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies.
Liposome  
Cancer  
/
HY-153136 LNP Lipid-1
LNP Lipid-1 (Method B) is a lipid compound. LNP Lipid-1 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-1 has potential applications in the transport of biologically active substances such as small molecule agents, proteins, and nucleic acids.
Liposome  
/
HY-171948 FO-35
FO-35 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNPs). FO-35 can be used to delivery mRNA to mouse muscle and nasal mucosa as well as ferret lungs.
Liposome  
Cancer  
/
HY-P11886 GNYTCEVTELTREGETIIELK-N3
GNYTCEVTELTREGETIIELK-N3 (GNYTCEVTELTREGETIIELK-Azide) is a conjugate of an azide (-N3) group and a CD47 functional peptide (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduces the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS) and reduces their accumulation in non-target tissues such as the liver and spleen. The azide group in GNYTCEVTELTREGETIIELK-N3 can undergo click chemistry reactions for applications such as constructing targeted drug delivery systems and nanoparticle modification.
Biochemical Assay Reagents  
/
HY-175409 Lipid 35 hydrochloride
Lipid 35 hydrochloride is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 35 hydrochloride can be used for lung-specific mRNA delivery for metastatic lung tumors research.
Liposome  
Cancer  
/
HY-171897 E10i-494
E10i-494 is an ionizable cationic branched endosomal disruptor (BEND) lipid. E10i-494 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vitro. E10i-494 can enhance transfection efficiency.
Liposome  
Cancer   Inflammation or Immune System Disease  
/
HY-W775262S Δ9-Tetrahydrocannabinolic acid-d3
Δ9-Tetrahydrocannabinolic acid-d3 is the deuterium labeled Δ9-Tetrahydrocannabinolic acid. Δ9-Tetrahydrocannabinolic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
/
HY-W440815 6-((4-Hydroxybutyl)amino)hexyl 2-hexyldecanoate
6-((4-Hydroxybutyl)amino)hexyl 2-hexyldecanoate is a lipid, it can be used to synthesis nanomaterials. 6-((4-Hydroxybutyl)amino)hexyl provides the use of the nano-lipid particle as the key component in nucleic acid delivery, including the components of the delivery carrier.
Liposome  
/
HY-P1813 PSA1 (141-150)
PSA1 (141-150), a prostate specific antigen 1 peptide, is used in the immunotherapy of cancer experiments.
Prostaglandin Receptor  
/
HY-P992518 Pumitamig (Mouse IgG2a)
Pumitamig (Mouse IgG2a) is the Mouse IgG2a control antibody for Pumitamig (HY-P991097). Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy.
VEGFR   PD-1/PD-L1  
Ovarian Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
/
HY-W414069 Thiocholesterol
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery.
Endogenous Metabolite   Liposome  
/
HY-178721 Lithocholic amide-C2-N(didecane)
Lithocholic amide-C2-N(didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N(didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N(didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor EphA2 and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway.
Drug Derivative   Ephrin Receptor   Interleukin Related   IFNAR  
Psoriasis  
/
HY-171784 Lipid PPz-2R1
Lipid PPz-2R1 is a lung-targeted lipid. Lipid PPz-2R1 is formulated into lipid nanoparticles (LNPs) for mRNA delivery. Lipid PPz-2R1 can be used for in situ lung cancer research.
Liposome  
Lung Cancer  
/
HY-157415 1,2-Dierucoyl-sn-glycero-3-PE
1,2-Dierucoyl-sn-glycero-3-PE (1,2-Dierucoyl-sn-3-phosphatidylethanolamine) is a phospholipid that contains erucic acid. 1,2-Dierucoyl-sn-glycero-3-PE can be used in the generation of lipid nanoparticles (LNPs) to deliver mRNA in vivo. 1,2-Dierucoyl-sn-glycero-3-PE can also be used to synthesize numerous PEG-conjugates for liposomes incorporation.
Liposome  
Inflammation or Immune System Disease  
/
HY-W440835D DSPE-PEG3400-DBCO
DSPE-PEG3400-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 3400 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Biochemical Assay Reagents  
Atherosclerosis and Inflammation  
/
HY-172699 DSPE-PEG2000-ANG
DSPE-PEG2000-ANG is a conjugate of DSPE-PEG2000-MAL and Angiopep-2. Angiopep-2 is a peptide ligand that targets LRP-1. DSPE-PEG2000-ANG is used to synthesize gadolinium-boron bifunctionalized lipid nanoparticles BPA-F&DOTA-Gd@LIPO-ANG with blood-brain barrier and glioma targeting properties.
Liposome   LDLR  
Glioma  
/
HY-141629S1 N-Palmitoyl-D-sphingomyelin-13C
N-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles.
Isotope-Labeled Compounds   Endogenous Metabolite   Liposome  
/
HY-D1409 DMTr-4'-F-U-CED-TBDMS phosphoramidite
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure.
DNA Stain   Phosphoramidites  
Blood or Cardio-cerebrovascular Disease  
/
HY-W341624 16:0 Ptd thioethanol sodium
16:0 Ptd thioethanol sodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-178736S 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine-d46
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine-d46 (DLPE-d46; 1,2-Dilauroyl-sn-glycero-3-PE-d46) is the deuterium labeled 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE; 1,2-Dilauroyl-sn-glycero-3-PE) is an anionic phospholipid. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine promotes the endocytosis of liposome-DNA complexes into target cells, and subsequently mediates membrane fusion between liposome carriers and endosomes to deliver DNA into the nucleus. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a component of anionic artificial viral envelope liposomes, which deliver plasmid DNA to hepatoma cells without serum inhibition. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine enables the construction of biocompatible non-viral gene delivery vector systems. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is applicable for liposome synthesis.
Isotope-Labeled Compounds   Liposome  
/
HY-W440835C DSPE-PEG1000-DBCO
DSPE-PEG1000-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 1000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Biochemical Assay Reagents  
Atherosclerosis and Inflammation  
/
HY-112251GL D-Lin-MC3-DMA (GMP Like)
D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
Liposome  
Cancer  
/
HY-N16041 N-Octadecyl-pSar25
N-Octadecyl-pSar25 is a lipid that is composed of a N-octadecyl unit conjugated to a pSar25 polymer. N-Octadecyl-pSar25 can be used to synthesize lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-P10999 INF7TAT-P55
INF7TAT-P55 (P55) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing.
Drug Derivative   Biochemical Assay Reagents  
/
HY-W1130442 DMA4-H228
DMA4-H228 is a highly spleen-targeted, ionizable cationic liposome. DMA4-H228 is used to prepare lipid nanoparticles (LNPs) loaded with mRNA for the delivery of mRNA in vivo.
Liposome  
/
HY-P992051 Anti-CD103 Antibody (hCD103.01A)
Anti-CD103 Antibody (hCD103.01A) is a monoclonal antibody targeting human CD103 and can be used in cancer immunotherapy and immunological research. Recommend Isotype Controls: human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Integrin  
Cancer   Inflammation or Immune System Disease  
/
HY-174972A mPEG-DPPE (MW 5000)
mPEG-DPPE (MW 5000) is an amphiphilic phospholipid-modified polymer that can be used to prepare lipid nanoparticles or liposomes for targeted drug delivery applications.
Biochemical Assay Reagents  
/
HY-156100 C12-4
C12-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation.
Liposome  
/
HY-10321G PD173074 (GMP)
PD173074 GMP is PD173074 (HY-10321) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. PD173074 is an orally active FGFR inhibitor that targets the transphosphorylation of FGFR1 and FGFR2 and blocks the FGF signaling pathway. By reducing the phosphorylation level of SMAD2 and altering the expression of Nodal/Activin target genes, PD173074 eliminates endothelial differentiation potential, thereby inhibiting the formation of capillary-like structures. PD173074 blocks the proliferation and colony formation of tumor cells and increases intratumoral cell apoptosis. PD173074 successfully reverses FGF-2-induced chemoresistance to enhance the effect of cisplatin (HY-17394) in small cell lung cancer models. PD173074 can be applied to research related to critical limb ischemia and small cell lung cancer.
FGFR   TGF-beta/Smad  
Small Cell Lung Cancer  
/
HY-P12011 MTS peptide
MTS peptide is a short peptide with a mitochondria-targeting sequence. In F-M-LNP, MTS peptide is displayed on the particle surface via thiol-maleimide conjugation, and is specifically responsible for being recognized by the mitochondrial proteins TOMM20/22, "anchoring" the nanoparticles to the outer mitochondrial membrane, followed by membrane potential-independent bilayer membrane penetration mediated by fluorinated lipids. MTS peptide can be used in the research of Leber's hereditary optic neuropathy.
Mitochondrial Metabolism  
Visual System Disease  
/
HY-168374A DSPE-PEG1000-Mannose
DSPE-PEG1000-mannose is an amphiphilic molecule that can be used to synthesize lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-W440885 DSPE-PEG5000-Ald
DSPE-PEG5000-Ald is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond.
Biochemical Assay Reagents  
/
HY-W1130450 Lipid ND-O1
Lipid ND-O1 is an ether-containing ionizable cationic lipid pKa of 6.6. Lipid ND-O1 can be used to generate lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo. Lipid ND-O1 LNPs can be studied in research on hepatic fibrosis.
Liposome  
Inflammation or Immune System Disease  
/
HY-159869 G0-C14 analog
G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP).
Liposome  
/
HY-171900 Lipid 114
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. Lipid 114 can be used to generate lipid nanoparticles (LNP) to deliver siRNA in vitro as well as in vivo. Lipid 114 LNPs encapsulating siRNA that targets IL-1β can reduce IL-1β expression in macrophages. Lipid 114 LNPs encapsulating siRNA that targets IL-1β also reduces hepatic and renal expression of IL-1β, as well as decreasing hepatic inflammation in mouse model with LPS-induced acute liver failure.
Liposome  
Inflammation or Immune System Disease  
/
HY-P11639 ppTG21
ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing.
Biochemical Assay Reagents  
/
HY-13642G RG108 (GMP)
RG108 (GMP) is RG108 (HY-13642) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC50=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.
DNA Methyltransferase  
Cancer  
/
HY-N16037 N-Dodecyl-pSar25
N-Dodecyl-pSar25 is a lipid that is composed of a N-dodecyl unit conjugated to a pSar25 polymer. N-Dodecyl-pSar25 can be used to synthesize lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
/
HY-177613 ALN-12115
ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
Kinesin  
Cancer  
/
HY-172330 Q1-SM-102 iodide
Q1-SM-102 iodide is a quaternary ammonium lipid derivative of SM-102 (HY-13454). Q1-SM-102 iodide can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Q1-SM-102 iodide is a carriers for targeting delivery of mRNA to immune organs.
Liposome  
Inflammation or Immune System Disease  
/
HY-W250187 DDMAB
DDMAB, or didodecyldimethylammonium bromide, is a cationic surfactant commonly used in a variety of industrial and research applications. It belongs to the family of quaternary ammonium compounds and has a positively charged head and a hydrophobic tail, which allows it to be used as a detergent, emulsifier and antimicrobial. Known for its ability to disrupt cell membranes, DDMAB is commonly used in microbiology to selectively isolate and identify bacteria. It is also used in nanotechnology to synthesize metal nanoparticles and other materials. In addition, DDMAB has the ability to interact with and penetrate cell membranes, which has potential applications in drug delivery, gene therapy, and other medical fields.
Biochemical Assay Reagents  
/
HY-171984 514O6,10
514O6,10 is an ionizable lipidoid containing a branched-tail. 514O6,10 can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to natural killer and dendritic cells within the lung. 514O6,10 can be used for the RNA therapies for lung diseases associated with immune cell dysregulation, including cancer, viral infections, and autoimmune disorders research.
Liposome  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-176754 TCL065
TCL065 is an ionizable lipid with a pKa of 6.3. TCL065 can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA as well as single-guide RNA (sgRNA) both in vitro and in vivo. TCL065-containing LNPs can studied in research for Duchenne muscular dystrophy and gene-editing technologies.
Liposome  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N15803 DOPE-RGD Lipid sodium
DOPE-RGD Lipid sodium is a lipid containing DOPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
/
HY-P11680 Boc-PNA-thioU(PMB)-OH
BOC-PNA-thioU(PMB)-OH is a peptide nucleic acid (PNA) monomer characterized by a PMB protecting group on its thiouracil, which enhances its binding affinity to adenine. BOC-PNA-thioU(PMB)-OH exhibits excellent resistance to enzymatic degradation and strong hybridization properties, making it valuable for applications in gene diagnosis, antisense therapy, and other molecular biology fields requiring higher binding strength and greater functionalization.
DNA/RNA Synthesis  
/
HY-174286 C16-18:1 PE
C16-18:1 PE is a lipid. C16-18:1 PE has the activity of promoting membrane fusion and enhancing endosomal escape, which can significantly improve the delivery efficiency of mRNA. C16-18:1 PE is used in the synthesis of lipid nanoparticles (LNP).
Liposome  
/
HY-W013078R 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (Standard)
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) (Standard) is the analytical standard of 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) (HY-W013078). This product is intended for research and analytical applications. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) is a zwitterionic saturated phosphatidylethanolamine bearing two myristoyl (C14:0) chains, and serves as a model membrane component, a neutral lipid component of lipid nanoparticles, and a cocoa butter crystallization nucleating agent. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is used in nucleic acid delivery, construction of artificial cell membrane models, and research on urothelial carcinoma.
Reference Standards   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-153371 50-C2-C9-4tail
50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.
Liposome  
/
HY-172328A (S)-O12-D3-I3
(S)-O12-D3-I3 is an ionizable cationic lipid (pKa = 6.39). (S)-O12-D3-I3 can be used to prepare lipid nanoparticles (LNPs) for in vitro and in vivo siRNA delivery. (S)-O12-D3-I3 can also be used in research on cancers such as liver cancer and breast cancer.
Liposome  
Breast Cancer   Liver Cancer  
/
HY-107413G SR11237 (GMP)
SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease.
RAR/RXR   Tyrosine Hydroxylase  
Inflammation or Immune System Disease   Parkinson's Disease   Osteoarthritis  
/
HY-151998S DMPG-d54
DMPG-d54 is the deuterium labeled DMPG (1,2-Dimyristoyl-sn-glycero-3-phosphatidylglycerol). DMPG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
/
HY-184529 5-TAMRA-LQIQSWSSSPC-Mal-PEG2000-DSPE
5-TAMRA-LQIQSWSSSP-PEG2000-DSPE is a PEG compound labeled with the fluorescent group 5-TAMRA. 5-TAMRA-LQIQSWSSSP-PEG2000-DSPE is commonly used to construct targeted liposomes, LNPs (lipid nanoparticles), micelles, or nanomedicine delivery systems.
Biochemical Assay Reagents   Fluorescent Dye  
/
HY-P11453 R9H6
R9H6 is a peptide containing nine arginine peptides and six histidine peptides. The LP(R9H6)m nanocomplex containing R9H6 exhibits high efficiency in mRNA delivery. R9H6 can be used in the research of anaplastic thyroid cancer.
Biochemical Assay Reagents  
Cancer  
/
HY-N16292 Chol-PEG2000 carboxylic acid
Chol-PEG2000 carboxylic acid is a PEG lipid that consists of a cholesterol and a carboxylic acid. Chol-PEG2000 carboxylic acid can be used to prepare lipid nanoparticles for drug delivery.
Liposome  
/
HY-P11351 Precursor-HhH
Precursor-HhH is a nucleic acid-binding peptide capable of non-specific interactions with RNA and double-stranded DNA (dsDNA). Precursor-HhH is promising for research of nucleic acid-targeted therapeutics.
DNA/RNA Synthesis  
Cancer  
/
HY-W440682 C13-113-tri-tail
C13-113-tri tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tri tail can be formulated into a lipid nanoparticle (LNP).
Liposome  
/
HY-D1408 DMTr-4'-Me-U-CED-TBDMS phosphoramidite
DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure.
DNA Stain   Phosphoramidites  
Blood or Cardio-cerebrovascular Disease  
/
HY-179863 BODIPY 505/515-C3-CONH-Oleic acid
BODIPY 505/515-C3-CONH-Oleic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-148830 Piperazine-bis(ethyl octadeca-9,12-dienoate)
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
Liposome  
/
HY-151508 Diamino lipid DAL4
Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity.
Liposome  
Cancer  
/
HY-159710 TNT-b10
TNT-b10 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). TNT-b10 is a carrier for both siRNA and mRNA.
Liposome  
/
HY-173380 C8 DG PEG 2000
C8 DG PEG 2000 (1,2-dioctanoyl-rac-glycero-3-methoxypolyethylene glycol-2000) is a PEG lipid consisting of a glycerol backbone with two C8 acyl chains and PEG 2000 units. C10 DG PEG 2000 can be used for lipid nanoparticle and liposome formation.
Biochemical Assay Reagents  
Cancer  
/
HY-P991634 IBI-325
IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research.

Species: Human

CD73   TNF Receptor   Interleukin Related   IFNAR  
Cancer   Inflammation or Immune System Disease  
/
HY-P10562 BMV Gag-(7−25)
BMV Gag-(7 25) is an arginine-rich peptide with cell-penetrating ability. BMV Gag-(7 25) can be used in drug delivery and gene therapy research.
TMV  
/
HY-N15990 4ME 16:0 Diether PE
4ME 16:0 Diether PE is a phospholipid that can be used to prepare lipid nanoparticles for drug delivery.

Source: Methanosarcina barkeri

Biochemical Assay Reagents  
/
HY-W1130459 (R)-C12-200
(R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery.
Liposome  
Squamous Cell Carcinoma  
/
HY-P11218 Lipo-PtIV-R8K
Lipo-PtIV-R8K is a nuclear targeting peptide containing R8K. Lipo-PtIV-R8K is a lipid PtIV prodrug amphiphilic molecule that can self assemble to form nanoparticles. Lipo-PtIV-R8K can be used in the research of cancer such as breast cancer.
Others  
Cancer  
/
HY-172501 DSPE-PEG5000-SP94
DSPE-PEG5000-Mal-CLPLIPTHIISFS is a PEG compound composed of DSPE and the liver cancer targeting peptide SP94 (HY-P11050A) (sequence SFSIIHTPILPL). SP94 exhibits specific binding to hepatocellular carcinoma (HCC) cells. DSPE-PEG5000-Mal-CLPLIPTHIISFS can be used to prepare lipid nanoparticles to form liver cancer-targeting nanocarriers.
Liposome  
Cancer  
/
HY-P1566 MPG, HIV related
MPG, HIV related is 27-aa peptide, derived from both the nuclear localisation sequence of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41 and is a potent delivery agent for the generalised delivery of nucleic acids and of oligonucleotides into cultured cells.
HIV  
Infection  
/
HY-163044 C12-SPM
C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases.
Liposome  
Infection  
/
HY-20457G TL8-506 (GMP)
TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy.
Toll-like Receptor (TLR)   Bacterial   Interleukin Related  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-W440835H DSPE-PEG10000-DBCO
DSPE-PEG10000-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 10000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Biochemical Assay Reagents  
Atherosclerosis and Inflammation  
/
HY-W591332A mPEG1000-DMPE
mPEG1000-DMPE is a PEGylated 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (14:0 PE) compound with a methyl group at the?other?end of the PEG chain. The PEG polymer exhibits amphiphatic behavior and helps to form stable micelles in an aqueous solution. It can be used to prepare nanoparticles or liposomes for targeted drug delivery applications.
Biochemical Assay Reagents  
/
HY-P11698 Guanidino-G-Clamp-PNA
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis.
DNA Alkylator/Crosslinker   Transthyretin (TTR)  
Diffuse Large B-cell Lymphoma  
/
HY-148701 mono-Pal-MTO
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.
Liposome  
Cancer  
/
HY-W1130429 4A3-SC10
4A3-SC10 is an ionizable cationic lipid (pKa = 6.57) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. 4A3-SC10 can be used for drug delivery in cancer.
Liposome  
Cancer  
/
HY-N16234 Chol-PEG1000 fluorescein
Chol-PEG1000 fluorescein is a fluorescent lipid that consists of a cholesterol-PEG1000 unit conjugated to fluorescein. Chol-PEG1000 fluorescein can be used to prepare lipid nanoparticles for drug delivery research (Ex/Em = 480/520 nm).
Fluorescent Dye  
/
HY-172500A DSPE-PEG3400-SP94
DSPE-PEG3400-Mal-CLPLIPTHIISFS is a PEG compound composed of DSPE and the liver cancer targeting peptide SP94 (HY-P11050A) (sequence SFSIIHTPILPL). SP94 exhibits specific binding to hepatocellular carcinoma (HCC) cells. DSPE-PEG3400-Mal-CLPLIPTHIISFS can be used to prepare lipid nanoparticles to form liver cancer-targeting nanocarriers.
Liposome  
Cancer  
/
HY-W440810 Undecyl 6-bromohexanoate
Undecyl 6-bromohexanoate can be useful for the preparation of lipid nanoparticles.
Liposome  
/
HY-N16294 DSPE-PEG8 DBCO
DSPE-PEG8-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DSPE-PEG8-DBCO can be used to prepare lipid nanoparticles for drug delivery.
Liposome  
/
HY-W725836 13:0 Lyso PI
13:0 Lyso PI is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-13689G Go 6983 (GMP)
Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury.
PKC   Histone Methyltransferase   DNA Methyltransferase   DNA/RNA Synthesis  
Ischemia-Reperfusion Injury  
/
HY-172500 DSPE-PEG2000-SP94
DSPE-PEG2000-Mal-CLPLIPTHIISFS is a PEG compound composed of DSPE and the liver cancer targeting peptide SP94 (HY-P11050A) (sequence SFSIIHTPILPL). SP94 exhibits specific binding to hepatocellular carcinoma (HCC) cells. DSPE-PEG2000-Mal-CLPLIPTHIISFS can be used to prepare lipid nanoparticles to form liver cancer-targeting nanocarriers.
Liposome  
Cancer  
/
HY-P11759 Myr-transportan-Cys
Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors.
Drug Derivative  
Cancer  
/
HY-179761 16:0 C4-BODIPY 505/515 DNP Cap PE ammonium
16:0 C4-BODIPY 505/515 DNP Cap PE ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-170455 18:1 PE (DOPE) pSar25
18:1 PE (DOPE) pSar25 is a derivative of polyethylene glycol that can be used for liposomal and lipid nanoparticle delivery systems.
Biochemical Assay Reagents  
/
HY-W1130412 DLPE-mPEG2000
DLPE-mPEG2000 is an amphiphilic phospholipid-modified polymer that can be used to prepare lipid nanoparticles or liposomes for targeted drug delivery applications.
Liposome  
/
HY-174972 mPEG-DPPE (MW 1000)
mPEG-DPPE (MW 1000) is an amphiphilic phospholipid-modified polymer that can be used to prepare lipid nanoparticles or liposomes for targeted drug delivery applications.
Biochemical Assay Reagents  
/
HY-174485 OVA mRNA (N1-Me-Pseudo UTP)
OVA mRNA (N1-Me-Pseudo UTP) is an mRNA encoding chicken ovalbumin. The substitution with N1-Me-Pseudo UTP (m1Ψ) improves protein expression and reduces innate immune response. OVA mRNA binds to the STING-activating polymer PD18 and is encapsulated in optimized lipid nanoparticles to construct an mRNA vaccine platform (PD18 LNP). This platform not only enhances the lymphatic delivery efficiency and protein expression of mRNA, but also potently adjuvates immune responses via activating the STING pathway.
mRNA  
Vaccine and Immunization  
/
HY-W749512 3β-Hydroxy-7-oxo-5-cholestenoic acid
3?-Hydroxy-7-oxo-5-cholestenoic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-179769 C17 Glucosyl(β) ceramide (d18:1/17:0)
C17 Glucosyl(β) ceramide (d18:1/17:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-W585353 BODIPY 505/515 PE
BODIPY?505/515 PE is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-171951 31hP
31hP is an asymmetric A3 lipid. 31hP can facilitate in vivo luciferase expression. 31hP can be rapidly degraded in the presence of esterase owing to two biocleavable ester bonds. 31hP can be used in the synthesis of lipid nanoparticles (LNPs).
Liposome  
/
HY-179764 α-Galactosyl-C16-dihydroceramide (d18:0/16:0)
α-Galactosyl-C16-dihydroceramide (d18:0/16:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-179839 BODIPY TMR Lyso PA ester ammonium
BODIPY TMR Lyso PA ester ammonium is a fluorescent lipid.
Biochemical Assay Reagents  
/
HY-165603 Si5-N14
Si5-N14 is a key component of siloxane-incorporated lipid nanoparticles (SiLNP), possessing pro-vascular repair and anti-tumor activities. In the transgenic GFP mouse model, Si5-N14 can mediate CRISPR-Cas9 editing. In the Lewis lung carcinoma (LLC) tumor-bearing mouse model, Si5-N14 can knock out the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) to exert an anti-tumor effect. In a mouse model of lung injury induced by viral infection, the delivery of Fibroblast Growth Factor-2 (FGF-2) mRNA via Si5-N14 can promote vascular repair, increase blood oxygen levels, and improve lung function. Si5-N14 shows promise for research in the fields of oncology, pneumonia, and cardiovascular diseases.
Liposome   VEGFR   FGFR  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W440809 Nonyl 8-bromooctanoate
Nonyl 8-bromooctanoate is a chemical reagent featuring a bromide linked to a larger ester chain consisting of a C8 ester coupled to a C9 chain. Bromide is easily displaced by nucleophiles in substitution reactions.Nonyl 8-bromooctanoate can be used as an intermediate in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-W1049124A PEG5000-C-DMG
PEG5000-C-DMG is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycerol (HY-128468). PEG5000-C-DMG can be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of siRNA.
Liposome  
Cancer  
/
HY-N16251 C16 Cy5 SM chloride
C16 Cy5 SM chloride is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-179820 C18:1 Galactosyl(β) ceramide (d18:1/18:1(9Z))
C18:1 Galactosyl(β) ceramide (d18:1/18:1(9Z)) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-159675 1-A-N
1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene.
Liposome  
Inflammation or Immune System Disease  
/
HY-N16077 C16 Cyclic LPA ammonium
C16 Cyclic LPA ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-157684 06:0 PG sodium
06:0 PG sodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-179742 18:1 PE-BODIPY 505/515 AF488 ammonium
18:1 PE-BODIPY 505/515 AF488 ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Lipid Metabolism  
/
HY-160269 DSPE-PEG2000-Fluor 488
DSPE-PEG2000-Fluor 488 is a PEG-dye-lipid conjugate consisting of a DSPE phospholipid and a Fluor 488 dye. DSPE is a phospholipid that spontaneously forms micelles in a water medium, and Fluor 488 is a cyanine dye that is widely used in fluorescence microscopy. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm. Polyethylene glycol lipids are commonly used for the stabilization of lipid nanoparticles.
Fluorescent Dye  
/
HY-179911 mPEG2000-DLG
mPEG2000-DLG is a PEG-based lipid that can be used to formulate lipid nanoparticles for drug delivery.
Liposome  
/
HY-179897 BODIPY TMR Lyso PE ester
BODIPY TMR Lyso PE ester is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-164720 DSPE-PEG4000-OH
DSPE-PEG4000-OH is a hydroxy-terminated phospholipid PEG polymer. The hydrophobic tails that allows the encapsulation and aggregation of other hydrophobic drugs, and the hydroxy-terminated can be further reacted. DSPE-PEG4000-OH can prepare liposomes or lipid nanoparticles, which can be used in drug delivery and promoting drug absorption research.
Liposome  
/
HY-N16199 (2E,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid
(2E,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-W800742 Heptadecan-9-yl 6-bromohexanoate
Heptadecan-9-yl 6-bromohexanoate is a chemical reagent featuring a bromide linked to a larger ester chain consisting of a C6 ester coupled to the central position of a C17 chain. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-179810 18:1 MGDG (synthetic)
18:1 MGDG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-179778 C11 BODIPY 505/515 GM3 ammonium
C11-BODIPY 505/515 GM3 ammonium is a C11-BODIPY 505/515-labeled GM3 ammonium that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Fluorescent Dye  
/
HY-W1130407 CP-LC-1073
CP-LC-1073 is a specific ionizable cationic amino lipid derived from the amino acid homocysteine. CP-LC-1073 can used in lipid nanoparticle (LNP) formulations for efficient in vivo delivery and expression of RNA (mRNA, cRNA, saRNA).
Liposome  
/
HY-W401062 2-Undecyloxirane
2-Undecyloxirane (1,2-Epoxytridecane) is a chemical reagent featuring an epoxy group on a C11 chain. The epoxy group undergoes ring opening in the presence of nucleophiles to form a branched structure containing a secondary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-179765 C17:0 GA2
C17:0 GA2 is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
Metabolic or Endocrine Disease  
/
HY-179960 1-Linoleo-2-linolenin
1-Linoleo-2-linolenin is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
Lipid Metabolism  
/
HY-W1121519 6,6′-Trehalose dioleate
6,6′-Trehalose dioleate is a glycolipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-W725837 16:0 Lyso PI ammonium
16:0 Lyso PI ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
Metabolic or Endocrine Disease  
/
HY-138170GL ALC-0315 (GMP Like)
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
Liposome   SARS-CoV  
Infection  
/
HY-179743 18:1 BODIPY 505/515 PE ammonium
18:1 BODIPY 505/515 PE ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-W040193S1 DSPC-d74
DSPC-d74 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-160204 16:0 Cardiolipin disodium
16:0 Cardiolipin (Diphosphatidylglycerol (16:0)) disodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Lipid Metabolism  
/
HY-157713 diC8PI(3,5)P2 triammonium
diC8PI(3,5)P2 (08:0 PI(3,5)P2) triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Lipid Metabolism  
/
HY-112251S D-Lin-MC3-DMA-13C3
D-Lin-MC3-DMA-13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
Isotope-Labeled Compounds  
/
HY-172335 C9-200
C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs). C9-200-based LNPs encapsulating mRNA encoding erythropoietin (EPO) can induced EPO production and stimulate red blood cell production in mice.
Liposome  
/
HY-165427 Lipid 11
Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems.
Liposome  
Cancer  
/
HY-169484 SIL lipid
SIL lipid is the synthetic ionized lipid, and can be used for synthesis of lipid nanoparticles (LNPs) for siRNA delivery.
Liposome  
/
HY-168776 (S)-C12-200
(S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery.
Biochemical Assay Reagents  
/
HY-173297 LNP Lipid-12
LNP Lipid-12 can be exploited for creating lipid nanoparticles (LNPs).
Liposome  
/
HY-171953 THP1 Lipid
THP1 Lipid is an ionizable lipidoid. THP1 Lipid can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to muscles with minimal toxicity and editing genes in specific liver tissues in tdTomato transgenic mice model. THP1 Lipid can be used for vaccine delivery and CRISPR/Cas9-mediated gene editing research.
Liposome  
/
HY-179776 C11-BODIPY 505/515 Galactosyl ceramide
C11-BODIPY 505/515 Galactosyl ceramide is a C11-BODIPY 505/515-labeled Galactosyl ceramide that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Fluorescent Dye  
/
HY-157643 18:0-20:4 PI (4,5) P2 triammonium
18:0-20:4 PI (4,5) P2 triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-179821 C18:1 Glucosyl(β) ceramide (d18:1/18:1(9Z))
C18:1 Glucosyl(β) ceramide (d18:1/18:1(9Z)) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-179895 mPEG2000-DPG
mPEG2000-DPG is a PEG-based lipid that can be used to formulate lipid nanoparticles for drug delivery.
Liposome  
/
HY-157685 06:0 PI(3,5)P2 ammonium
06:0 PI(3,5)P2 (PIP2[3',5'](6:0/6:0)) ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-W765990 α-Galactosyl-C16-ceramide (d18:1/16:0)
α-Galactosyl-C16-ceramide (d18:1/16:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
Lipid Metabolism  
/
HY-179890 16:0 C11 BODIPY 505/515 DG
16:0 C11 BODIPY 505/515 DG is a C11-BODIPY 505/515-labeled DG that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Fluorescent Dye  
/
HY-179779 C11-BODIPY 505/515 Sphingomyelin
C11-BODIPY 505/515 Sphingomyelin is a C11-BODIPY 505/515-labeled Sphingomyelin that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Fluorescent Dye  
/
HY-W1052697 (R)-DPPE-mPEG2000
(R)-DPPE-mPEG(2000) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-W800783 DSTAP chloride
DSTAP chloride (CDESA) is a cationic lipid that used in the formation of lipid nanoparticles (LNPs). DORI chloride has high transfection efficiency.
Liposome  
/
HY-P990174 Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32)
Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32) is an anti-mouse Pan-endothelial Cell Antigen/MECA-32 IgG2a monoclonal antibody. Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32) can label endothelial cells. Anti-Mouse Pan-endothelial Cell Antigen/MECA-32 Antibody (MECA-32) is often used for immunohistochemistry, delivery of siRNA and immunofluorescence.

Species: Mouse

Others  
/
HY-179775 C11-BODIPY 505/515 Ceramide-1-phosphate ammonium
C11-BODIPY 505/515 Ceramide-1-phosphate ammonium is a C11-BODIPY 505/515-labeled ceramide-1-phosphate ammonium that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Fluorescent Dye  
/
HY-179896 BODIPY TMR Lyso PC ester
BODIPY TMR Lyso PC ester is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-W588184 (Rac)-C22-Ceramide
(Rac)-C22-Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes.
Biochemical Assay Reagents  
/
HY-173286 LNP Lipid-182
LNP Lipid-182 can be employed in the development of lipid nanoparticles (LNPs).
Liposome  
/
HY-164723 DSPE-PEG10000-OH
DSPE-PEG10000-OH is a hydroxy-terminated phospholipid PEG polymer. The hydrophobic tails that allows the encapsulation and aggregation of other hydrophobic drugs, and the hydroxy-terminated can be further reacted. DSPE-PEG10000-OH can prepare liposomes or lipid nanoparticles, which can be used in drug delivery and promoting drug absorption research.
Liposome  
/
HY-159713 Lipid R6
Lipid R6 is a lipid molecule that can be used to synthesize liposomes and is the lipid component in lipid nanoparticle (LNP) systems.
Liposome  
/
HY-W010514R trans-Cyclohexane-1,2-diol (Standard)
trans-Cyclohexane-1,2-diol (Standard) is the analytical standard of trans-Cyclohexane-1,2-diol (HY-W010514). This product is intended for research and analytical applications. trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells.
Endogenous Metabolite   Reference Standards  
/
HY-W440820 Bis(bis(2-carboxyethyl)aminopropyl)methylamine
Bis(bis(2-carboxyethyl)aminopropyl)methylamine is a symmetrical branched linker featuring three tertiary amines and four carboxylic acids. Each carboxylic acid is open to forming esters or amides. It can be used in developing lipid nanoparticles.
Liposome  
Cancer  
/
HY-172344 DB-lipidoid 11-10-8
DB-lipidoid 11-10-8 is an ionizable cationic lipid (pKa = 6.22). DB-lipidoid 11-10-8 can be used in lipid nanoparticle (LNP) studies for in vivo delivery of mRNA.
Biochemical Assay Reagents  
/
HY-176764 17:1 Lyso PI ammonium
17:1 Lyso PI ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-173295 LNP Lipid II-10
LNP Lipid II-10 can be used in the development of lipid nanoparticles (LNPs).
Liposome  
/
HY-179823 C18(2R-OH) Galactosyl(β) ceramide
C18(2R-OH) Galactosyl(β) ceramide is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-171904 BCP-NC2-C12
BCP-NC2-C12 is an ionizable cationic lipid. BCP-NC2-C12 can be used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA. BCP-NC2-C12 LNPs mediated an approximately 90% reduction in PCSK9 serum protein levels via CRISPR/Cas9 gene knockout.
Liposome  
/
HY-164721 DSPE-PEG6000-OH
DSPE-PEG6000-OH is a hydroxy-terminated phospholipid PEG polymer. The hydrophobic tails that allows the encapsulation and aggregation of other hydrophobic drugs, and the hydroxy-terminated can be further reacted. DSPE-PEG6000-OH can prepare liposomes or lipid nanoparticles, which can be used in drug delivery and promoting drug absorption research.
Liposome  
/
HY-W251490 Bis(linoleyl) ketone
Bis(linoleyl) ketone is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-W142525 Didodecylamine
Didodecylamine (N-Dodecyldodecan-1-amine) is a chemical reagent featuring a secondary amine linked to two saturated C12 tails. The secondary amine is a versatile substrate which can be used to build a wide variety of bonds. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-179828 DLin-C-DAP
DLin-C-DAP is a cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-179744 18:2 MGDG (synthetic)
18:2 MGDG (synthetic) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-179898 BODIPY TMR PI(4,5)P2 ester ammonium
BODIPY TMR PI(4,5)P2 ester ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-179838 BODIPY-C8-sphingosine
BODIPY-C8-sphingosine is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-Z18432 TMA-Cholesterol (Plant)
TMA-Cholesterol (Plant) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-179822 C18:1 Lactosyl(β) ceramide (d18:1/18:1)
C18:1 Lactosyl(β) ceramide (d18:1/18:1) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-168392 Propylene glycol monopalmitate
Propylene glycol monopalmitate can be used to synthesize solid lipid nanoparticles (SLNs) for the delivery of bioactive compounds.
Biochemical Assay Reagents  
/
HY-N16110 17:0 Cyclic LPA ammonium
17:0 Cyclic LPA ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-179824 C24:0 Galactosyl(β)ceramide(d18:1/24:0)
C24:0 Galactosyl(β)ceramide(d18:1/24:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-179823A C18(2S-OH) Galactosyl(β) ceramide
C18(2S-OH) Galactosyl(β) ceramide is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-W749522 3-Oxo-4-cholestenoic acid
3-Oxo-4-cholestenoic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-N16072 22:6 PE
22:6 PE is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-N16029 C18:0 Fuc-GM1 Ceramide (d18:1/18:0)
C18:0 Fuc-GM1 Ceramide (d18:1/18:0) is a ganglioside that can be used to synthesize lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
/
HY-N16140 18:0-20:4 PG sodium
18:0-20:4 PG (PG(18:0/20:4(5Z,8Z,11Z,14Z))) sodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-176512 FO-32
FO-32 is an ionizable lipid and mRNA delivery carrier with state-of-the-art aerosolized mRNA delivery capability. FO-32 delivers mRNA to mouse muscle, nasal mucosa, lung, as well as ferret lung epithelium (including conducting airways). FO-32 can be used in studies related to the generation of lipid nanoparticles (LNPs) and the optimization of drug delivery.
Liposome  
/
HY-W599718 (R)-3-Hydroxydecanoic acid
(R)-3-Hydroxydecanoic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-153376 LNP Lipid-6
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP).
Liposome  
/
HY-153867 C12 Mono-Sulfo galactosyl(β) ceramide (d18:1/12:0) ammonium
C12 Mono-Sulfo galactosyl(β) ceramide (d18:1/12:0) ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-W585399 BODIPY 505/515 Lyso PA
BODIPY?505/515 Lyso PA is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-179986 1-Palmitin-2-linolenin
1-Palmitin-2-linolenin is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-168775 Lipid 29d
Lipid 29d is an unsaturated ionizable cationic lipid that can be utilized in the formation of lipid nanoparticles and the delivery of mRNA.
Biochemical Assay Reagents  
/
HY-N16341 N-C24:1-Desoxymethylsphingosine
N-C24:1-Desoxymethylsphingosine is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-W800743 Heptyl 6-bromohexanoate
Heptyl 6-bromohexanoate is a chemical reagent featuring a bromide linked to a larger ester chain consisting of a C6 ester coupled to a C7 alcohol. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-172288 N-TETAMINE-pSar45
N-TETAMINE-pSar45 is a polysarcosine (pSar) derivative featuring an N-tetamine head group and a 45-mer polysarcosine tail. Sarcosine is an amino acid derivated that is being developed as an alternative to PEG for in vivo applications due to its biodegradability and highly reduced antigenicity. pSar-lipid derivatives such as this may be applied in the development of lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-153868 C17-Mono-sulfo galactosyl(β) ceramide (d18:1/17:0) ammonium
C17-Mono-sulfo galactosyl(β) ceramide (d18:1/17:0) ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-W440811 6-Bromohexyl 2-hexyldecanoate
6-Bromohexyl 2-hexyldecanoate is a lipid. 6-Bromohexyl 2-hexyldecanoate can be used to build lipid nanoparticles and nanomaterials.
Liposome  
/
HY-158867 DOSPA (hydrochlorid)
DOSPA hydrochlorid is a frequently utilized cationic lipid in the generation of Lipid Nanoparticles (LNPs) for the development of mRNA vaccines, including the COVID-19 vaccine.
Liposome  
Infection  
/
HY-157711 08:0 PG sodium
08:0 PG sodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-179881 16:0(2R-OH) Ceramide
16:0(2R-OH) Ceramide is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-157649 18:0-20:4 PI (3,5) P2 triammonium
18:0-20:4 PI (3,5) P2 triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-W800728 1,1'-[2-(Hydroxymethyl)-1,3-propanediyl] dilinoleate
1,1'-[2-(Hydroxymethyl)-1,3-propanediyl] dilinoleate is a lipid molecule featuring two linoleic acids and a primary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-169801 Rofleponide 21-palmitate
Rofleponide 21-palmitate is a lipophilic Corticosteroid prodrug. Rofleponide 21-palmitate reduces subcutaneous edema, plasma haptoglobin levels, and plasma levels of IL-6, KC, IP-10, MCP-1. Rofleponide 21-palmitate increases and prolongs mRNA-encoded protein expression in lipid nanoparticle formulations.
Glucocorticoid Receptor   Interleukin Related  
Inflammation or Immune System Disease  
/
HY-153375 LNP Lipid-5
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP).
Liposome  
/
HY-180053 1,2-Eicosapentaenoin-3-linolein
1,2-Eicosapentaenoin-3-linolein is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-D2431 Galactose-PEG-Cy3
Galactose-PEG-Cy3 is a Cy3 (HY-D0822) labeled Galactose-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Galactose-PEG improves drug cellular uptake and reduces endosomal degradation, and can be used in drug delivery.
Fluorescent Dye  
/
HY-179836 DOPE-PEG-Azide ammonium
DOPE-PEG-Azide ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-134780 L-369
L-369 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles and deliver mRNA.
Liposome  
/
HY-180002 1-Stearin-2-linolein
1-Stearin-2-linolein is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-W040193GL DSPC (GMP Like)
DSPC (GMP Like) (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is DSPC (HY-W040193) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Liposome  
/
HY-179777 C11-BODIPY 505/515 Glucosyl ceramide
C11-BODIPY 505/515 Glucosyl ceramide is a C11-BODIPY 505/515-labeled Glucosyl ceramide that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).
Fluorescent Dye  
/
HY-177921 PL53
PL53 is a kind of cycloalkylamine lipid nanoparticles. PL53 exhibits outstanding transfection efficiency both in vitro and in vivo, especially showing strong protein expression ability and potential tissue targeting after intramuscular injection. PL53 can be used for the study of nucleic acid delivery.
Liposome  
/
HY-W585339 BODIPY 505/515 PS ammonium
BODIPY?505/515 PS ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-153827 C12 Glucosyl(β) ceramide (d18:1/12:0)
C12 Glucosyl(β) ceramide (d18:1/12:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
Lipid Metabolism  
/
HY-179899 BODIPY TMR Lyso PI ester ammonium
BODIPY TMR Lyso PI ester ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-179910 mPEG2000-DCG
mPEG2000-DCG is a PEG-based lipid that can be used to formulate lipid nanoparticles for drug delivery.
Liposome  
/
HY-179900 BODIPY TMR Lyso PS ester ammonium
BODIPY TMR Lyso PS ester ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
Lipid Metabolism  
/
HY-145465 C17 Lactosylceramide (d18:1/17:0)
C17 Lactosylceramide (d18:1/17:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Others  
/
HY-157691 22:6 PG sodium
22:6 PG sodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
/
HY-175410 DOPE-C8
DOPE-C8 (1,2-Dioloeoyl-sn-glycero-3-phosphoethanolamine-C8; 1,2-DOPE-C8) is a zwitterionic phospholipid derived from DOPE that has been used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA.
Liposome  
/
HY-172510 N-Hexadecyl-pSar25
N-Hexadecyl-pSar25 is a polysarcosine (pSar) derivative featuring a hexadecyl head group and a 25-mer polysarcosine tail. Sarcosine is an amino acid derivated that is being developed as an alternative to PEG for in vivo applications due to its biodegradability and highly reduced antigenicity. pSar-lipid derivatives such as this may be applied in the development of lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-179837 DPPE-mPEG sodium
DPPE-mPEG sodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Liposome  
/
HY-159725 BAmP-O16B
BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs).
Liposome  
/
HY-172526 4A3-SCC-10
4A3-SCC-10 is a biodegradable ionizable lipid containing disulfide bonds. 4A3-SCC-10 can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. 4A3-SCC-10 can be used for broad applications such as gene editing, vaccine, and cancer detection.
Liposome  
Cancer  
/
HY-160580 G1-OC2-K3-E10
G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs).
Liposome  
/
HY-W800825 Octadecanedioic acid mono-L-carnitine ester
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
Liposome  
Cancer  
/
HY-165604 C14-490
C14-490 is an ionizable cationic lipid used for the formulation of lipid nanoparticles (LNPs) for mRNA delivery. C14-490 LNPs can be surface-functionalized with CD45 antibodies to enable targeted delivery to hematopoietic stem cells (HSCs), mediate efficient mRNA delivery and CRISPR-Cas9 gene editing in fetal HSCs in utero, with potent and durable genome modulation in HSCs and their progeny. C14-490 is a key component of the Systematically optimized Targeted Editing Machinery (STEM) LNPs for in vivo HSC gene editing applications.
Liposome  
/
HY-P5840A Cyclo(RGDyC) TFA
Cyclo(RGDyC) TFA is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) TFA can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer.
Others  
Cancer  
/
HY-W250183B Polyoxyethylene (20) stearyl ether
Polyoxyethylene (20) stearyl ether (Polyethylene glycol octadecyl ether (n～20)) is a PEGylated lipid surfactant. Polyoxyethylene (20) stearyl ether is used in studies on the formation and stabilization of lipid nanoparticles.
Liposome  
/
HY-134541G SM-102 (GMP)
SM-102 (GMP) is SM-102 (HY-134541) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
Liposome  
Infection  
/
HY-138622S1 24:0 Lyso PC-d4
24:0 Lyso PC-d44 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.
Isotope-Labeled Compounds  
/
HY-W440813 Heptadecan-9-yl 8-bromooctanoate
Heptadecan-9-yl 8-bromooctanoate can be useful for the building or modification of lipid nanoparticles.
Liposome  
/
HY-P4084A KLA seq acetate
KLA seq acetate is a cell membrane-penetrating α-helical amphipathic model peptide. KLA seq acetate conjugates peptide nucleic acids (PNAs) for delivery to mammalian cells. KLA seq acetate covalently links targeted mRNA and fluorescein to form a delivery system that has low re-export and is less resistant to serum effects.
Others  
/
HY-P991126 Ciltistotug
Ciltistotug is a monoclonal antibody targeting human CD40 (TNFRSF5). Ciltistotug activates immune cells after binding to CD40, exerting immunostimulatory and antitumor activities. Ciltistotug is promising for research of cancer immunotherapy.

Species: Human

TNF Receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-P3402 HBpep-K
HBpep-K is a peptide that can form co aggregated droplets. HBpep-K can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K can protect mRNA from RNase degradation. HBpep-K is commonly used for drug delivery.
Amino Acid Derivatives  
/
HY-P991125 Cenzestotug
Cenzestotug is a monoclonal antibody targeting human tumor necrosis factor receptor superfamily member 4 (TNFRSF4). Cenzestotug activates relevant immune cells by binding to TNFRSF4, exerting immunostimulatory and antitumor activities. Cenzestotug is promising for research of cancer immunotherapy.

Species: Human

TNF Receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-159855 CAP 2 hydrochloride
CAP 2 (Cholesterol-amino-phosphate 2) hydrochloride is Cholesterol-amino-phosphate (CAP) lipid. CAP 2 can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
/
HY-113736 Glycyllysine
Glycyllysine is a polypeptide that can be used in the synthesis of antibodies and amino acid type gemini surfactants. Glycyllysine has potential applications in modifying plasmid/gemini/lipid (P/G/L) nanoparticles transport carriers.
Amino Acid Derivatives  
/
HY-159715 Lipid DIM1
Lipid DIM1 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid DIM1 is a carrier for both siRNA and mRNA.
Liposome  
/
HY-P3402A HBpep-K acetate
HBpep-K acetate is a peptide that can form co aggregated droplets. HBpep-K acetate can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K acetate can protect mRNA from RNase degradation. HBpep-K acetate is commonly used for drug delivery.
Amino Acid Derivatives  
/
HY-159865 CL15F6
CL15F6 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
/
HY-156936 RCB-02-4-8
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice.
Liposome  
/
HY-156985 Lipid AX4
Lipid AX4 is an ionizable cationic lipid that can be used to construct lipid nanoparticles (LNPs) for in vivo delivery of nucleic acids (e.g., mRNA, circRNA).
Liposome  
/
HY-P991294 MGTA-117 Antibody
MGTA-117 is a humanized monoclonal antibody targeting CD117. MGTA-117 can be used for synthesis of antibody-drug conjugate (ADC), utilizing an amanitin payload. MGTA-117 has potent anti-tumor activity and increases survival in three acute myeloid leukemia (AML) xenograft hNSG mice models (Kasumi-1, AML PDX 1 and AML PDX 2). MGTA-117 enables hematopoietic stem cell transplantation (HSCT) preprocessing in AML, myelodysplasia with excess blasts (MDS-EB) and gene therapy.

Species: Human

ADC Antibodies  
Cancer  
/
HY-P4118 EB1 peptide
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research.
Amino Acid Derivatives   Peptide-Drug Conjugates (PDCs)  
/
HY-W013078 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) is a zwitterionic saturated phosphatidylethanolamine bearing two myristoyl (C14:0) chains, and serves as a model membrane component, a neutral lipid component of lipid nanoparticles, and a cocoa butter crystallization nucleating agent. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is used in nucleic acid delivery, construction of artificial cell membrane models, and research on urothelial carcinoma.

Source: Penicillium expansum

Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P5423C GALA-Cys
GALA-Cys is a chemically modified GALA peptide (HY-P5423) that retains GALA functions while acquiring strong covalent conjugation capability. GALA-Cys undergoes pH-driven reversible secondary structure transition, rearranges into an amphipathic α-helix, self-oligomerizes, penetrates lipid membranes to form pores, and disrupts lipid bilayers, thereby enabling endosomal escape and cytosolic cargo delivery. GALA-Cys can be conjugated with lipid DPTE for integration into liposomes, self-assembles into a tilted monolayer on gold surfaces, and serves as a pH-responsive coating for particle surface functionalization. GALA-Cys is applicable to studies related to targeted cargo delivery.
Others  
/
HY-159714 Lipid HTO12
Lipid HTO12 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid HTO12 is a carrier for both siRNA and mRNA.
Liposome  
/
HY-159854 C14-O2
C14-O2 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
Cancer  
/
HY-176753 Lipid 20b
Lipid 20b is a thiophene ionizable cationic lipid. Lipid 20 b can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Lipid 20b can be studied in research for enhancing mRNA vaccine delivery and transfection efficacy.
Liposome  
Inflammation or Immune System Disease  
/
HY-150117 Lipid 6
Lipid 6 is an ionizable amino lipid. Lipid 6 can be used to synthesize lipid nanoparticles. Lipid 6 can be used in RNA delivery research.
Liposome  
/
HY-173289 LNP Lipid-26
LNP Lipid-26 can be applied in the generation of lipid nanoparticles (LNPs).
Biochemical Assay Reagents  
/
HY-Z12017 Cholesterol impurity 4
Cholesterol impurity 4 is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Biochemical Assay Reagents  
/
HY-158796 L202
L202 is an ionizable cationic lipid (pKa=6.04) that can be used for the study of mRNA and lipid nanoparticles.
Liposome  
/
HY-D2441 TAT-PEG-Cy3
TAT-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, Cell membrane penetrating peptide (TAT) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. TAT-PEG-Cy3 can be used for cell targeted delivery and biological imaging.
Fluorescent Dye  
Cancer  
/
HY-160908 Lipid 88
Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA.
Liposome  
/
HY-N12762 DGTS
DGTS, as described, is a structural isomer of DGTA and one of the most common betaine lipids found in microalgae, particularly abundant in Chlorophyceae. DGTS is a helper lipid that is structurally similar to DSPE or DOPE.

Source: Amphora sp

Liposome  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-138622S 24:0 Lyso PC-13C6
24:0 Lyso PC-13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.
Isotope-Labeled Compounds  
/
HY-W040193S3 DSPC-d83
DSPC-d83 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-W590573 C3 Ceramide
C3 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes.
Biochemical Assay Reagents  
/
HY-165895 1,2-Dipentadecanoyl-sn-glycero-3-phosphatidylethanolamine
1,2-Dipentadecanoyl-sn-glycero-3-phosphatidylethanolamine is a phospholipid and can be used in the preparation of lipid nanoparticles.
Liposome  
Metabolic or Endocrine Disease  
/
HY-158861 C3-K2-E14
C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical branches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.
Liposome  
/
HY-W590672 C22-Dihydroceramide
C22 Dihydroceramide is a lipid featuring two saturated hydrophobic tails. Ceramides may be used in developing lipid nanoparticles or liposomes.
Biochemical Assay Reagents  
/
HY-150116 Lipid 1
Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
Liposome  
/
HY-164722 DSPE-PEG8000-OH
DSPE-PEG8000-OH is a hydroxy-terminated phospholipid PEG polymer. The hydrophobic tails that allows the encapsulation and aggregation of other hydrophobic drugs, and the hydroxy-terminated can be further reacted. DSPE-PEG8000-OH can prepare liposomes or lipid nanoparticles, which can be used in drug delivery and promoting drug absorption research.
Liposome  
/
HY-159735 Lipid 23
Lipid 23 is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNP). Lipid 23 can be used for mRNA delivery.
Liposome  
/
HY-W040193S4 DSPC-d4
DSPC-d4 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-P10217 PD-1/PD-L1-IN-42
PD-1/PD-L1-IN-42 (Compound B8.4) is an inhibitor of the interaction between PD-1 and PD-L1, with an EC50 of 0.1 μM. PD-1/PD-L1-IN-42 can be used for the research of cancer immunotherapy.
PD-1/PD-L1  
Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-112764GL mPEG2000-DMG (GMP Like)
mPEG2000-DMG (GMP Like) is mPEG2000-DMG (HY-112764) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
Liposome  
Metabolic or Endocrine Disease  
/
HY-181133 Budesonide oleate (C18:1)
Budesonide oleate (C18:1) (Budesonide 21-oleate) is a prodrug of Budesonide (HY-13580), and can be used as the active ingredient of anti-inflammatory lipid nanoparticles for targeted delivery of anti-inflammatory agents.
Drug Intermediate  
Inflammation or Immune System Disease  
/
HY-159716 Lipid 50
Lipid 50 (compound 50) is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 50 is a carrier for both siRNA and mRNA.
Liposome  
/
HY-153377 Lipid 14
Lipid 14 is an ionizable amino lipid. Lipid 14 delivers mRNA into target cells, significantly enhancing the in vivo expression efficiency and immunogenicity of mRNA. Lipid 14 can be used to synthesize lipid nanoparticles (LNPs). Lipid 14 can be used for studies of SARS-CoV-2 and Yersinia pestis.
Liposome   SARS-CoV   Bacterial  
Inflammation or Immune System Disease   Viral Infection   Bacterial Infection   SARS-CoV-2 Infection  
/
HY-P5840 Cyclo(RGDyC)
Cyclo(RGDyC) is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer.
Biochemical Assay Reagents  
Cancer  
/
HY-176518 ssPalmE-P4-C2
ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research.
Liposome   Ser/Thr Protease  
Infection   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P4087B Cys(Npys)-(Arg)9 acetate
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection.
HIV  
/
HY-P10999A INF7TAT-P55 acetate
INF7TAT-P55 acetate (P55 acetate) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 acetate serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing.
Drug Derivative   Biochemical Assay Reagents  
/
HY-149156 Lipid C24
Lipid C24 is a cationic ionizable lipid that can be used for synthesizing lipid nanoparticles. Lipid C24 can be used in the study of drug delivery.
Liposome  
Cancer  
/
HY-153187 LNP Lipid-4
LNP Lipid-4 (Compound 8-8) is a lipid compound. LNP Lipid-4 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-4 has potential applications in the transportation of biologically active substances.
Liposome  
/
HY-173247 GalNAc-NAG37 phosphoramidite
GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery.
C-type Lectin-like Receptors (CTLRs)  
/
HY-W440991 DOPE-PEG2000-Amine
DOPE-PEG2000-Amine (DOPE-PEG2000-NH2) is a polyethylene glycol-derivatized phospholipid that can be used to construct liposomes and lipid nanoparticles. DOPE-PEG-Amine is used for non-covalent functionalization of single-walled carbon nanotubes (SWCNTs) to enhance their water dispersibility and biocompatibility. DOPE-PEG-Amine can be applied in research related to photothermal applications.
Biochemical Assay Reagents  
/
HY-160705 PNI 132
PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.
Liposome  
Cancer  
/
HY-D2433 Glucose-PEG2000-Cy3
Glucose-PEG2000-Cy3 is a Cy3 (HY-D0822) labeled Glucose-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Glucose-PEG improves drug cellular uptake and reduces endosomal degradation, and can be used in drug delivery.
Fluorescent Dye  
/
HY-177531 S-Ac7-DOg
S-Ac7-DOG is a cationic lipid with biodegradability, low immunogenicity and high nucleic acid transfection capacity, which is commonly used to construct lipid nanoparticles for nucleic acid molecule delivery. S-Ac7-DOG can bind to mRNA, microRNA and self-amplifying RNA through electrostatic interaction. Lipid nanoparticles formed by S-Ac7-DOG enter cells via an energy-dependent endocytic pathway, release nucleic acid cargos, induce antigen-specific CD8+ T cell responses, promote the generation of precursor memory T cells, and regulate neuroinflammatory pathways. S-Ac7-DOG can be used in the research of retinal diseases, neuroinflammation and cancer.
Liposome  
Cancer   CNS Infection   Retinopathy  
/
HY-160512 Lipid 9
Lipid 9 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.
Liposome  
/
HY-173287 LNP Lipid-48
LNP Lipid-48 is an SM-102 analog used in the formation of lipid nanoparticles (LNPs).
Liposome  
/
HY-185260 AA76-lipid
AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer.
Liposome  
Pancreatic Cancer  
/
HY-157252 CL4F8-6
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics.
Liposome  
Cancer  
/
HY-P10862A AH-D peptide TFA
AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy.
Exosomes   Virus Protease  
Cancer   Infection  
/
HY-W440927 Stearic acid-PEG2000-NHS
Stearic acid-PEG2000-NHS is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond. Reagent grade, for research purpose.
Liposome  
/
HY-W1130456 Lipid TD5
Lipid TD5 is an ionizable cationic lipid with a pKa value of 7.3. Lipid TD5 can be used to prepare lipid nanoparticles (LNPs), which efficiently deliver mRNA and the CRISPR/Cas9 system to the central nervous system and enable their expression.
Liposome  
Neurological, Eye or Ear Disease  
/
HY-P3486 GADGVGKSAL
GADGVGKSAL is a mutant KRAS G12D 10mer peptide. GADGVGKSAL can be used as an immunogenic neoantigen for cancer immunotherapy research.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-P10862 AH-D peptide
AH-D peptide is a brain-penetrant antiviral agent disrupting highly curved lipid membranes. AH-D peptide exhibits broad-spectrum antiviral activity against ZIKV, Dengue virus, Chikungunya virus, yellow fever virus and Japanese encephalitis virus, with
IC50
values of 11.9, 12.5, 35.7, 206 and 136 nM, respectively. AH-D peptide reduces the viral load in the brain, suppresses inflammation, protects neurons, and does not damage the blood brain barrier. AH-D peptide restores antitumor immunity by decreasing circulating PD-L1+ exosomes, reducing intratumoral immunosuppressive cells (regulatory T cells, myeloid-derived suppressor cells), and enhancing T cell function. AH-D peptide inhibits membrane-enveloped viruses and cancer cell metastasis in vivo. AH-D peptide exhibits no immunogenicity and has negligible effects on normal tissues. AH-D peptide can be used for research in Zika virus and other mosquito-borne viruses, cancer immunotherapy and metastasis.
Exosomes   Virus Protease  
Cancer   Infection  
/
HY-W598178 93-O17O
93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
Liposome  
/
HY-P3487 GAGGVGKSA
GAGGVGKSA is a wild type KRAS G12D 9mer peptide. GAGGVGKSA can be used as an immunogenic neoantigen for cancer immunotherapy research.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-W013122 Cholesteryl n-butyrate
Cholesteryl n-butyrate is a cholesterol ester composed of cholesterol and butyrate, two naturally occurring substances. Cholesteryl n-butyrate can be used to synthesize solid lipid nanoparticles (SLNs) with inhibitory activity on the adhesion and migration of colon cancer cells, providing a delivery system for the anticancer drug butyrate.
Biochemical Assay Reagents  
Cancer  
/
HY-W590531 80-O16B
80-O16B is an ionizable cationic lipid containing disulfide bonds that can be used to prepare lipid nanoparticles (LNP).
Biochemical Assay Reagents   Liposome  
/
HY-155882 mPEG750-amine
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells.
Biochemical Assay Reagents  
Cancer  
/
HY-122426 1-Bromoundecane
1-Bromoundecane (n-Undecyl bromide) is a chemical reagent featuring a bromide along a saturated C11 chain. Bromide is easily displaced by nucleophiles such as alcohols or amines. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-159858 Lipid 16
Lipid 16 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads. Lipid 16 as a potent cell type-specific ionizable lipid for the CD11bhi macrophage population without an additional targeting moiety.
Liposome  
Cancer  
/
HY-160554 C12-113
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.
Liposome  
Infection   Inflammation or Immune System Disease  
/
HY-N16040 DMG-pSar25
DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations.
Liposome  
/
HY-P99834 Crefmirlimab
Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., 89Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research.

Species: Human

Transmembrane Glycoprotein  
Lung Cancer  
/
HY-134541GL SM-102 (GMP Like)
SM-102 (GMP Like) is SM-102 (HY-134541) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
Liposome  
Infection  
/
HY-P10153 gH625
gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research.
Others  
/
HY-157524 1,2-O-Dioctadecyl-sn-glycerol
1,2-O-Dioctadecyl-sn-glycerol (Compound 7b) is a lipid molecule that can be used to synthesize thermostable lipid nanoparticle.
Biochemical Assay Reagents  
/
HY-W141932 N-Stearoylglycine
N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films.
Endogenous Metabolite  
/
HY-145794 ZA3-Ep10
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.
Liposome  
Lung Cancer  
/
HY-N1420AR Rhamnose monohydrate (Standard)
Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas.
Reference Standards   Endogenous Metabolite   MMP   Interleukin Related   PKA  
Cancer   Infection   Metabolic or Endocrine Disease  
/
HY-W105704 HEPBS
HEPBS is a zwitterionic buffer with a pH range (7.6-9.0) similar to that of biological systems. HEPBS can be used for cell culture. HEPBS also promotes mRNA delivery.
Biochemical Assay Reagents  
/
HY-P10424 OPBP-1
OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research.
PD-1/PD-L1  
Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-P3488 GADGVGKSA
GADGVGKSA is a mutant KRAS G12D 9mer peptide. GADGVGKSA can be used as an immunogenic neoantigen for cancer immunotherapy research.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-P11070 SDSSD
SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.
Others  
/
HY-141629S2 N-Palmitoyl-D-sphingomyelin-d9
N-Palmitoyl-D-sphingomyelin-d9 (Sphingomyelin 16:0-d9) is deuterium labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles.
Isotope-Labeled Compounds   Endogenous Metabolite   Liposome  
/
HY-134541S6 SM-102-d4
SM-102-d4 is the deuterium labeled SM-102 (HY-134541). SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
Isotope-Labeled Compounds   Liposome  
Infection  
/
HY-W923255R 3-(Octanoyloxy)propane-1,2-diyl bis(decanoate) (Standard)
3-(Octanoyloxy)propane-1,2-diyl bis(decanoate) (Standard) is the analytical standard of 3-(Octanoyloxy)propane-1,2-diyl bis(decanoate) (HY-W923255). This product is intended for research and analytical applications. 3-(Octanoyloxy)propane-1,2-diyl bis(decanoate) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Reference Standards   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-D2762 18:1 PE AF 594 triammonium
18:1 PE AF 594 triammonium is a fluorescently labeled phospholipid probe. 18:1 PE AF 594 triammonium can be used as a fluorescent tracer for lipid nanoparticles (LNPs). 18:1 PE AF 594 triammonium is promising for research of drug delivery systems.
Fluorescent Dye  
Cancer  
/
HY-P0311A LAH4 TFA
LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.
Bacterial  
Infection  
/
HY-168399 PEG(2000)-C-DMG
PEG(2000)-C-DMG is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycerol (HY-128468). PEG(2000)-C-DMG can be used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA.
Liposome  
Cancer  
/
HY-W440835E DSPE-PEG5000-DBCO
DSPE-PEG5000-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 5000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Biochemical Assay Reagents  
Atherosclerosis and Inflammation  
/
HY-153852 LNP Lipid-7
LNP Lipid-7 is a cationic lipid. LNP Lipid-7 can be used to prepare lipid nanoparticles (LNPs) for the delivery of drugs such as nucleic acids.
Liposome  
/
HY-177069 4A3-SC7
4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform.
Liposome  
/
HY-113217S Cholesteryl oleate-d7
Cholesteryl oleate-d7 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-153737 113-N16B
113-N16B is an ionizable cationic lipid that can be used for the synthesis of lipid nanoparticles. 113-N16B delivers mRNA to pulmonary endothelial cells. 113-N16B can be formulated as a component into hybrid lipid nanoparticles for lung-specific delivery of mRNA (including MFSD7C mRNA and luciferase mRNA) in mice. 113-N16B is applicable to research related to lymphangioleiomyomatosis, sickle cell disease, and hemolysis-induced lung injury.
Liposome  
Leukemia/Lymphoma/Myeloma   Acute Lung Injury   Sickle Cell Disease  
/
HY-D0920 TOTO-3
TOTO-3 is a cyanine nucleic acid intercalating fluorescent probe that binds to both RNA and DNA (Ex=642 nm, Em=660 nm). TOTO-3 cannot enter intact cells, but can penetrate cells with permeabilized plasma membranes, staining cytoplasmic RNA and nucleoli to distinguish intact cells from damaged ones. TOTO-3 is taken up by macrophages in an ultrasound-independent manner. TOTO-3 accumulates in tumor cells via ultrasound-mediated enhancement of plasma membrane permeability. TOTO-3 supports optical imaging for real-time assessment of plasma membrane integrity, nucleic acid detection, and monitoring of ultrasound-mediated intracellular delivery processes. TOTO-3 is applicable to studies related to rectal cancer.
Fluorescent Dye  
Colorectal Cancer  
/
HY-P0311 LAH4
LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.
Bacterial  
Infection  
/
HY-159726 C10-200
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery.
Liposome  
/
HY-34419 Dioctylamine
Dioctylamine (Di-n-octylamine) is a secondary amine that can be used in the seed-mediated growth synthesis of InAs quantum dots. Dioctylamine serves as an intermediate for constructing lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-W583869 1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.
Liposome  
Metabolic or Endocrine Disease  
/
HY-109163 Treprostinil palmitil
Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease.
Prostaglandin Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Hypertension  
/
HY-148702 di-Pal-MTO
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.
Liposome  
Cancer  
/
HY-P4076 MPG peptides, Pβ
MPG peptides, Pβ is an amphipathic cell-penetrating peptide. MPG peptides, Pβ consists of three components: the hydrophobic fusion sequence (GALFLGFLGAAGSTMGA) of HIV glycoprotein 41, a spacer domain (WSQP), and the nuclear localization signal (KKKRKV) of the large T antigen of Simian virus 40. MPG peptides, Pβ can form stable non-covalent complexes with nucleic acids (including DNA) through electrostatic interactions and improve their intracellular delivery. MPG peptides, Pβ can be used in studies of HIV-1-related immune responses.
HIV   DNA Alkylator/Crosslinker  
HIV-1 Infection  
/
HY-150150F Cy3-siRNA Negative Control
Cy3-siRNA Negative Control is Cy3-labeled SiRNA Negative Control (HY-150150). Cy3-siRNA Negative Control can be used for easy visualization and assessment of transfection efficiency.
Small Interfering RNA (siRNA)  
Inflammation or Immune System Disease  
/
HY-153186 LNP Lipid-3
LNP Lipid-3 is an ionizable lipid that can be used to synthesize lipid nanoparticles. LNP Lipid-3 is applicable for mRNA delivery.
Liposome  
/
HY-150118 Lipid 8
Lipid 8 is an ionizable amino lipid that can be used to synthesize lipid nanoparticles (LNPs). Lipid 8 is applicable to research in drug delivery.
Liposome  
/
HY-P11058 OVA(250-264)
OVA(250-264) (OVAvac) (OVAp) is an antigen peptide that can be from ovalbumin (OVA) presented by the class I MHC molecule, H-2Kb. OVA(250-264) combined withαMSLN (anti-MSLN antibody) significantly induces antigen-specific CD8+ T cell generation and infiltration for enhancing antitumor efficacy in orthotopic pancreatic cancer mice model. OVA(250-264) can be used for neoantigen vaccine development in pancreatic cancer immunotherapy research.
MHC  
/
HY-W591476C m-PEG550-thiol
m-PEG550-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.
Biochemical Assay Reagents  
/
HY-148049 TT3
TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency.
Liposome  
/
HY-159067 DEAE-dextran, MW 500000 hydrochloride
DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes.
Biochemical Assay Reagents  
Cancer  
/
HY-154974 LNP Lipid-8
LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8+ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases.
Liposome  
Cancer  
/
HY-W590674 C26-Ceramide
C26 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes.
Drug Derivative  
/
HY-160439 Ionizable lipid-2
Ionizable lipid-2 is a cationic lipid for nucleic acid delivery, with the ability to form lipid nanoparticle mRNA vaccines that exhibit in vitro stability and immunostimulatory activity. Ionizable lipid-2 can be used in studies related to herpes zoster, mRNA vaccines and nucleic acid delivery.
Liposome   Biochemical Assay Reagents  
Infection  
/
HY-W004440 2,2'-Piperazine-1,4-diyldiethanamine
2,2'-(Piperazine-1,4-diyl)diethanamine is a piperazine with two N-ethanamine groups. This type of molecule may be used to build drug molecules or design novel ionizable aminolipid head groups for lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-153235 COVID-19 Spike Protein mRNA-LNP
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing mRNA encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2.
mRNA   SARS-CoV   Liposome  
Infection  
/
HY-134782 OF-Deg-Lin
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
Liposome  
/
HY-W040193S DSPC-d70
DSPC-d70 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-145973A 3'OMe-m7GpppAmpG ammonium solution (100 mM)
3’OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) ammonium solution (100 mM) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3’OMe-m7GpppAmpG ammonium solution (100 mM) effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3’OMe-m7GpppAmpG ammonium solution (100 mM) is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research.
Nucleoside Antimetabolite/Analog   SARS-CoV  
/
HY-159717 Lipid 331
Lipid 331 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 331 is a carrier for both siRNA and mRNA.
Liposome  
/
HY-160552 244cis
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels.
Liposome  
/
HY-P10950A PD-L1 inhibitory peptide TFA
PD-L1 inhibitory peptide TFA is an inhibitor targeting the PD-1/PD-L1 interaction. PD-L1 inhibitory peptide TFA inhibits the PD-1-mediated apoptosis signaling pathway, maintains the survival and activity of T cells, activates the anti-tumor effect of cytotoxic T lymphocytes, and significantly improves the survival rate of mice in fungal sepsis models. PD-L1 inhibitory peptide TFA can be used for research on sepsis, breast cancer and other related diseases, as well as immunotherapy.
PD-1/PD-L1   Apoptosis  
Cancer   Inflammation or Immune System Disease  
/
HY-P4086 Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to
nAChR on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer.
RABV   nAChR  
Cancer   Neurological, Eye or Ear Disease  
/
HY-153231A eGFP mRNA-LNP (500 ng/μL)
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability.
Fluorescent Dye   Liposome  
/
HY-126359 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (SLPC; 18:0-18:2 PC) is an endogenous phospholipid marker molecule in the glycerophospholipid metabolic pathway. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine is a core component of the phospholipid bilayer of biological membranes and a key responsive lipid for radiation injury and cardiometabolic diseases. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine constitutes the phospholipid bilayers of cell membranes and high-density lipoprotein (HDL), and regulates the core activity of lipoprotein functional homeostasis. The content of 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine in mouse serum shows a significant dose-dependent decrease with increasing ionizing radiation dose, and its level in human HDL also decreases significantly in metabolic syndrome. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can serve as a biological dosimeter marker for ionizing radiation injury, and is used for rapid and accurate assessment of radiation absorbed dose in exposed individuals. 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can also act as a lipidomics research target for cardiometabolic diseases such as lipid metabolic syndrome and early-onset coronary heart disease.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Heart Disease  
/
HY-W032014 Octylamine
Octylamine (n-Octylamine) is a chemical reagent featuring a primary amine and a saturated C8 tail. The primary amine is a versatile substrate which can be used to build a wide variety of bonds. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
Biochemical Assay Reagents  
/
HY-W440995 DOPE-PEG2000-Mal
DOPE-PEG2000-Mal is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.
Liposome  
Cancer  
/
HY-139306 BAMEA-O16B
BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing.
Liposome  
Inflammation or Immune System Disease  
/
HY-170704 DSPE-PEG2000-TCO
DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis.
Liposome  
Cancer   Metabolic or Endocrine Disease  
/
HY-148648 Lipid 29
Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles.
Liposome  
/
HY-126437I Poly-L-lysine hydrobromide (MW 1000-5000)
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer.
Biochemical Assay Reagents   DNA Alkylator/Crosslinker   Amino Acid Derivatives  
Lung Cancer  
/
HY-W010514 trans-Cyclohexane-1,2-diol
trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W590681 113-O12B
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA.
Liposome  
/
HY-145795 OF-02
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
Liposome  
/
HY-D0835 Hydroxylapatite (25-45 μm)
Hydroxylapatite (Hydroxyapatite) (25-45 μm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (25-45 μm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (25-45 μm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (25-45 μm) can be used in research on osteoarthritis, gout, and atherosclerosis.

Source: bones

Others  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-D2100B Cy5-DSPE chloride
Cy5-DSPE chloride is a far-infrared fluorescent phospholipid (λex/λem = 600/665 nm). Cy5-DSPE chloride is used to label liposomes, membranes and lipid nanoparticles, and can be applied to tracking and imaging studies of liposomes.
Fluorescent Dye  
/
HY-150229 306-N16B
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies.
Liposome  
Lung Cancer  
/
HY-153378 Lipid 15
Lipid 15 is an ionizable lipid with an ethanolamine linker and acid-sensitive hydrophobic tail. Lipid 15 can be used for the generation of Lipid nanoparticles (LNPs) and drug delivery research.
Liposome  
/
HY-N3540 Caraphenol A
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively.
Others  
Inflammation or Immune System Disease  
/
HY-141629 N-Palmitoyl-D-sphingomyelin
N-palmitoyl-D-sphingomyelin (sphingomyelin 16:0) is a component of LDL-carrying liposomes. N-palmitoyl-D-sphingomyelin can be used in colorectal cancer research.
Liposome   Endogenous Metabolite  
Cancer  
/
HY-P4121 L17E
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles.
Potassium Channel  
Cancer   Inflammation or Immune System Disease  
/
HY-171306 MK16
MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research.
Liposome  
/
HY-46759 Genevant CL1
Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines.
Liposome  
Infection  
/
HY-P5423 GALA
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems.
Exosomes   Liposome  
Metastatic Melanoma  
/
HY-112755 DODMA
DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery.
Liposome  
/
HY-P5307 Peptide A5K
Peptide A5K (INF7-A5K-TAT) is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy.
Biochemical Assay Reagents  
/
HY-P99175 KWAR 23
KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research.

Species: Human

CD47  
Cancer  
/
HY-P10152 INF7
INF7 is a derivative of the N-terminal domain of the HA2 protein and is sensitive to pH. INF7 disrupts the stability of endosomal membranes through a mechanism independent of membrane fusion. INF7 can be used to enhance the endosome escape of complex or liposome-encapsulated proteins. Co-encapsulation of INF7 and molecular imaging probes in liposomes can enhance intracellular signaling and probe retention.
Biochemical Assay Reagents  
Infection  
/
HY-170333 Lipid A-11
Lipid A-11 (Compound A-11) (CICL1) is an ionizable cationic lipid. Lipid A-11 can be used to prepare lipid nanoparticles. Lipid A-11 can be used in research involving T cell-targeted transfection.
Liposome  
Inflammation or Immune System Disease  
/
HY-P991097 Pumitamig
Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy.

Species: Human

VEGFR   PD-1/PD-L1  
Ovarian Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
/
HY-148842 C14-4
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity.
Liposome  
Inflammation or Immune System Disease  
/
HY-P86946 LNP Antibody (YA6639)
LNP Antibody (YA6639) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LNP.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-K2018 OptiLNP RNA Transfection Reagent

MCE OptiLNP RNA Transfection Reagent is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into common cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2019 OptiLNP RNA Transfection Reagent (Stem Cells)

MCE OptiLNP RNA Transfection Reagent (Stem Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into stem cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2020 OptiLNP RNA Transfection Reagent (Primary Immune Cells)

MCE OptiLNP RNA Transfection Reagent (Primary Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into primary immune cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2021 OptiLNP RNA Transfection Reagent (Immune Cells)

MCE OptiLNP RNA Transfection Reagent (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into immune cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2022 In vivo OptiLNP RNA Transfection Reagent (Systemic Effect)

MCE In vivo OptiLNP RNA Transfection Reagent (Systemic Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions systemically.

Cell Biology Cell Culture Cell Transfection

/
HY-K2025 In vivo OptiLNP RNA Transfection Reagent (Lung-targeted)

MCE In vivo OptiLNP RNA Transfection Reagent (Lung-targeted) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA via intravenous injection in experimental animals.

Cell Biology Cell Culture Cell Transfection

/
HY-K2026 OptiLNP Short-Chain RNA Transfection Reagent

MCE OptiLNP Short-Chain RNA Transfection Reagent is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of short-chain RNA into common cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2027 OptiLNP Gene Editing Kit

MCE OptiLNP Gene Editing Kit is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing in common cells (adherent or suspension cells).

Cell Biology Cell Culture Cell Transfection

/
HY-K2033 OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells)

MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology to achieve highly efficient nucleic acid(eg. pDNA、mRNA、sgRNA、siRNA) delivery into Jurkat cells. It is designed for in vitro transfection of Jurkat cells and is well suited for applications in immunotherapy, tumor immunology, and other immune cell-related research.

Cell Biology Cell Culture Cell Transfection

/
HY-K2034 OptiLNP Antibody-ctLNP RNA Transfection Reagent (Human Primary T Cells)

MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology and is specifically optimized for human primary T cells. It enables efficient and targeted RNA delivery, improving transfection efficiency in difficult-to-transfect primary T cells. The kit is ideally suited for applications including CAR-T and TCR-T cell engineering, cancer immunology research, immune cell engineering, and in vitro T cell functional studies.

Cell Biology Cell Culture Cell Transfection

/
HY-K2035 Fluc mRNA (N1-Me-pUTP)

MCE Fluc mRNA (N1-Me-pUTP) is widely used for evaluating lipid nanoparticle (LNP) delivery efficiency, validating mRNA transfection reagents, assessing in vitro and in vivo mRNA expression, IVIS bioluminescence imaging, and screening novel nucleic acid delivery systems. It is commonly used as a positive control or reporter mRNA.

Cell Biology Cell Culture Cell Transfection

/

Keywords

Lipid nanoparticles | LNP | Nucleic acid delivery | mRNA delivery | siRNA delivery | RNA therapeutics | Gene therapy | mRNA vaccine | Ionizable lipids | Endosomal escape | CRISPR delivery | Cancer immunotherapy | Non-viral vectors | Nanomedicine | Precision medicine