2. Metabolic Enzyme/Protease
  3. Liposome
  4. 4A3-SC7

4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform.

For research use only. We do not sell to patients.

4A3-SC7

4A3-SC7 Chemical Structure

CAS No. : 1857340-77-2

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4A3-SC7 Related Antibodies

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  • Purity & Documentation

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Description

4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform[1].

Molecular Weight

1411.07

Formula

C71H131N3O16S4
CAS No.
Appearance

Viscous Liquid

Color

yellow

SMILES

O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCC)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (141.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (70.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7087 mL 3.5434 mL 7.0868 mL
5 mM 0.1417 mL 0.7087 mL 1.4174 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (1.77 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 0.7087 mL 3.5434 mL 7.0868 mL 17.7171 mL
5 mM 0.1417 mL 0.7087 mL 1.4174 mL 3.5434 mL
10 mM 0.0709 mL 0.3543 mL 0.7087 mL 1.7717 mL
15 mM 0.0472 mL 0.2362 mL 0.4725 mL 1.1811 mL
20 mM 0.0354 mL 0.1772 mL 0.3543 mL 0.8859 mL
25 mM 0.0283 mL 0.1417 mL 0.2835 mL 0.7087 mL
30 mM 0.0236 mL 0.1181 mL 0.2362 mL 0.5906 mL
40 mM 0.0177 mL 0.0886 mL 0.1772 mL 0.4429 mL
50 mM 0.0142 mL 0.0709 mL 0.1417 mL 0.3543 mL
60 mM 0.0118 mL 0.0591 mL 0.1181 mL 0.2953 mL
DMSO 80 mM 0.0089 mL 0.0443 mL 0.0886 mL 0.2215 mL
100 mM 0.0071 mL 0.0354 mL 0.0709 mL 0.1772 mL
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4A3-SC7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4A3-SC71857340-77-2LiposomeInhibitorinhibitorinhibit

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