Myr-transportan-Cys 

Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors^[1][2].

Through modular assembly with targeting peptides (e.g., iRGD) and stabilizing polymers (PEG), Myr-transportan-Cys can construct advanced nanodelivery platforms for tumor-specific gene silencing and enhanced immune checkpoint inhibitor therapy^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3154.93

C₁₅₁H₂₅₇N₃₅O₃₅S

{myristic acid-Gly}-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-Cys

{myristic acid-Gly}-WTLNSAGYLLGKINLKALAALAKKILC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kwon EJ, et al. Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids. Mol Pharm. 2020;17(9):3633-3642.  [Content Brief]

  [2]. Buss CG, et al. Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics. Proc Natl Acad Sci U S A. 2020;117(24):13428-13436.  [Content Brief]